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  • 1
    Electronic Resource
    Electronic Resource
    Fatigue and magnetic resonance imaging activity in multiple sclerosis (1999)
    Springer
    Journal of neurology 246 (1999), S. 454-458 
    Details
    ISSN: 1432-1459
    Keywords: Key words Multiple sclerosis ; Fatigue ; Magnetic resonance ; imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fatigue is a frequent and often severe symptom in multiple sclerosis. Pathogenic mechanisms proposed for fatigue include the release of proinflammatory cytokines, which is thought to have an important effect on changes in the blood-brain barrier (BBB). To investigate whether fatigue is related to BBB disruption we studied 11 relapsing-remitting MS patients participating in a multicenter longitudinal study comparing the sensitivity of monthly enhanced magnetic resonance imaging (MRI) after standard-dose and triple-dose injection of gadolinium-diethylene triaminopentoacetic acid (Gd-DTPA). Serial Gd-enhanced MRI studies were performed in two separate sessions every 4 weeks for 3 months. An expanded version of the Fatigue Severity Scale, including 29 items, was administered 24 h before each MRI examination. No relationship was found between the number and volume of Gd-enhancing lesions and fatigue scores at any monthly examination over the study period. Furthermore changes in MRI activity were not significantly related to changes in fatigue scores. These results were obtained on triple-dose delayed scanning, which is more sensitive than standard-dose scanning in detecting areas of BBB disruption. Our preliminary results thus do not support the hypothesis of a relationship between BBB alterations and fatigue severity in multiple sclerosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050382
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Antiphospholipid antibodies and cerebral artery dissection: Two frequent causes of brain ischemia in young adults (1994)
    Springer
    Neurological sciences 15 (1994), S. 221-227 
    Details
    ISSN: 1590-3478
    Keywords: brain ischemia ; young ; antiphospholipid antibodies ; artery dissection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Gli Autori riportano l'incidenza di anticorpi antifosfolipidi e dissezioni arteriose in 75 pazienti reclutati in uno studio multicentrico sull'ischemia cerebrale focale del giovane adulto. Gli anticorpi antifosfolipidi erano presenti in 9 pazienti (12%) mentre dissezioni arteriose sono state evidenziate in 11 casi (14%). Gli A. ribadiscono la necessità di un accurato studio dei parametri emocoagulativi ed immunologici oltre l'utilizzo di nuove tecniche di neuroimmagine nella ricerca delle cause di eventi ischmeici nei giovani.
    Notes: Abstract As part of a multicenter study on ischemic stroke in the young, we report the occurrence of high antiphospholipid antibody (aPLs) levels and cerebral dissection in 75 patients. These represent the two most frequent non-thromboembolic causes of cerebral ischemia in our population. Increased aPL titres were found in nine cases (12%); cerebral artery dissection in eleven (14%). Our data stress the need to modify the classical diagnostic approach to cerebral ischemia by including hematological assessments and new neuroimaging techniques as screening tests.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02342452
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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