ISSN:
1432-1440
Keywords:
Type A natriuretic peptide (CDD/ ANP-99-126)
;
Bronchodilation
;
Asthma therapy
;
Lung function
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Type A natriuretic peptide (CDD/ANP99-126) in its circulating form was analyzed with respect to the localization of its bronchodilating effects in asthmatic subjects in vivo. The intravenous infusion of 5.7, 11.4, and 17.1 pmol kg−1 min− CDD/ANP-99-126 caused a significant bronchodilation of both central and peripheral airways. While the localization of the bronchodilating effects was similar to β2-agonists, an improvement in lung function parameters comparable to these substances was not observed. But other members of the natriuretic peptide family may reveal a stronger bronchodilating potency.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00180545
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