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  • 1
    Electronic Resource
    Electronic Resource
    No evidence for constitutional chromosome instability in testicular cancer (1992)
    Springer
    Human genetics 〈Berlin〉 89 (1992), S. 338-340 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Chromosome aberrations in 20 lymphocytes of 20 patients with testicular germ cell tumors (TGCT) treated with surgery alone were compared with those of 20 cells from 20 healthy controls using standard G-banding technique. No increase in structural aberrations was found in the cancer group. An unexpected finding was that of more cells with losses of chromosomes being present in the control group. These losses predominantly affected small chromosomes in the control group, whereas the pattern of chromosome loss was different in the cancer group. The literature claiming increased chromosome instability in TGCT patients is reviewed. Point estimates and 95% confidence intervals to exclude such a hypothesis based on our results were calculated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220554
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  • 2
    Electronic Resource
    Electronic Resource
    Does the service at a large oncologic out-patient clinic satisfy the patients' perceived need? (1996)
    Bingley : Emerald
    International journal of health care quality assurance 9 (1996), S. 24-29 
    Details
    ISSN: 0952-6862
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Medicine , Economics
    Notes: Describes the physical status and quality of life in ambulatory oncologic patients seen at the Norwegian Radium Hospital (NRH) and assesses their satisfaction with the out-patient service. During a two-week period in 1993, 517 consecutive patients completed a qualify-of-life questionnaire (EORTC QLQ-C30) during their out-patient visit at the NRH. The results of the EORTC QLQ-C30 were compared with those from a similar study performed in 1991 (211 patients evaluated during one week).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/09526869610124209
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours (2000)
    [s.l.] : Nature America Inc.
    Nature genetics 24 (2000), S. 197-200 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Testicular germ-cell tumours (TGCT) affect 1 in 500 men and are the most common cancer in males aged 15–40 in Western European populations. The incidence of TGCT has risen dramatically over the last century. Known risk factors for TGCT include a history of undescended testis (UDT), testicular ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/72877
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  • 4
    Electronic Resource
    Electronic Resource
    Phase I/II tolerability/pharmacokinetic study with one-hour intravenous infusion of doxifluiridine (5′-dFUrd) 3 g/m2 VS 5 g/m2 QD x 5 per month (1986)
    Springer
    Cancer chemotherapy and pharmacology 18 (1986), S. 252-256 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Eighteen patients with advanced solid cancer were treated with daily 5′-dFUrd infusions given over 1 h on days 1–5 of a 4-week cycle. Nine patients received 3 g/m2 5′-dFUrd daily and another nine patients 5 g/m2. One patient on 5 g/m2 5′-dFUrd was not fully evaluable for tolerability due to early death (progressive disease) 4 weeks after the first cycle. A total of 48 cycles was given. The gastrointestinal and hematological toxicity was generally mild (grade 1–2). Central neurotoxicity (ataxia, unsteadiness, diplopia, dysarthria, sometimes confusion) was observed in 7 of 8 patients on 5 g/m2 5′-dFUrd leading to premature discontinuation of treatment in 3 patients (after 2 cycles). Only 3 of the 9 patients in the 3 g/m2 group had slight signs of cerebellopathy. Typically, the reversible neurological side effects started at the end of the 2nd week of a cycle. The serum elimination kinetics of 5′-dEUrd and its metabolites 5-FU and 5′-dFUH2 have been investigated in the serum and showed very low intra- and interindividual variations. Peak concentrations of the 5′-dFUrd at the end of the infusion approximated 500 μmol/l and 1000 μmol/l for the 3 g/m2 and 5 g/m2 group, respectively. The peak of the serum 5-FU was reached at the same time, the ratio 5-FU/5′-dFUrd being around 10%. The elimination half-life time for 5-FU was protracted by a factor of 2–3 compared with the direct injection of 5-FU. Monthly infusion of 5′-dFUrd 5 mg/m2 per day on days 1–5 lead to an unacceptable frequency and degree of neurological toxicity. Similar infusions of 5′-dFUrd 3 g/m2 per day on days 1–5 were well tolerated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00273397
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  • 5
    Electronic Resource
    Electronic Resource
    Doxifluridine (5′-dFUrd) in patients with advanced colorectal carcinoma (1985)
    Springer
    Cancer chemotherapy and pharmacology 15 (1985), S. 161-163 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Infusion of 5′-dFUrd (2.0–3.0 g/m2 over 1 h on days 1–5 every 3rd week) resulted in one partial response in 21 patients with advanced and progressing colorectal cancer. No patient had received chemotherapy before the 5′-dFUrd trial. Hematological and gastrointestinal toxicity were generally mild. In 4 patients peripheral neurotoxicity was diagnosed during treatment, whereas transient cerebellopathy was observed in one. Cardiac side effects (repeated angina pectoris following 5′-dFUrd infusion) led to discontinuation of treatment after two courses in ont superior to conventional 5-FU treatment in colorectal cancer. Neurological and cardiac side effects are rare but may be a problem in individual patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00257528
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  • 6
    Electronic Resource
    Electronic Resource
    Patients' and doctors' perception of long-term morbidity in patients with testicular cancer clinical stage I (1996)
    Springer
    Supportive care in cancer 4 (1996), S. 118-128 
    Details
    ISSN: 1433-7339
    Keywords: Testicular cancer stage I ; Long-term psychosocial and physical morbidity ; Doctors' and patients' assessment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Patient-based questionnaires were designed with the aim to identify and rank long-term somatic and psychosocial morbidity in patients with low-stage testicular cancer. A further intention was to compare patients' assessments with experienced doctors' general opinion on quality of life items in cured testicular cancer patients. In pilot study I, 103 tumour-free patients ranked items of physical and psychosocial morbidity after having had various kinds of treatment. Though the ranking procedure appeared to cause some difficulties amongst the patients and subsequently was abandoned, the results indicated considerable differences between the patients' and doctors' evaluations. In pilot study II patients were asked to score the different items. The questionnaire of pilot study II was completed by 107 patients from the Norwegian Radium Hospital (NRH) and 99 relapse-free patients from the Royal Marsden Hospital (RMH) with testicular cancer stage I at least 1 year after infradiaphragmatic radiotherapy (n = 94) or adjuvant chemotherapy (2 cycles,n=26), or patients who had been followed on the surveillance program (n = 86). A total of 93 doctors completed a similar questionnaire, thereby expressing their general opinion on long-term morbidity in comparable testicular cancer patients as seen during routine clinical follow-up. Both the irradiated patients and those on the surveillance program reported slight degrees of Raynaud-like phenomena, neurotoxicity and ototoxicity, most probably representing “background morbidity” in an age-matched general male population. Doctors tended to underestimate their patients' somatic morbidity, but often overestimated the degree of psychological distress, in particular in patients on the surveillance program. Significant differences between RMH and NRH patients with regard to sexual problems and to leisure time activity may be explained by cultural differences in the two countries. The items presented in the questionnaire used identify important issues for patients cured of testicular cancer which may be used in future multicentre trans-cultural studies assessing these patients' quality of life. This will provide sufficient data for psychometric testing and, together with the findings from patients' free comments, support the final design of a testicular cancer quality of life module.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01845761
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  • 7
    Electronic Resource
    Electronic Resource
    Maternal health and pre- and perinatal characteristics in the etiology of testicular cancer: a prospective population- and register-based study on Norwegian males born between 1967 and 1995 (1998)
    Springer
    Cancer causes & control 9 (1998), S. 475-486 
    Details
    ISSN: 1573-7225
    Keywords: Childhood ; Norway ; perinatal risk factors ; prenatal risk factors ; register-based study ; testicular cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: The aim of the present prospective study was to identify possible risk factors of testicular cancer (TC) in relation to gestation and birth.Methods: Based on data from compulsory birth and cancer registration in Norway, odds ratios (ORs) of TC were estimated. Results: Among 868068 males born between 1967 and 1995, 268 cases of germ cancer had developed by June 1996, 32 TCs before 5 years of age and 236 TCs thereafter, 48 cases being seminomas and 220 non-seminomas. There was a tendency of an inverse association between parity and TC. A previous finding from Sweden linking neonatal jaundice to risk of non-seminomas was confirmed (adjusted OR=2.1, 95 percent confidence interval [CI]=1.3-6.9). Significant associations were also seen for seminomas and TC diagnosed after 5 years of age. Maternal disease diagnosed before pregnancy increased the risk of TC significantly, particularly in the age group 0-4 years: Adjusted OR=3.0, CI=1.4-6.3. Retained placenta was significantly associated with both seminomas and non-seminomas and with TC diagnosed after 5 years of age. Conclusions: The findings of this study support the existing hypothesis that pre- and perinatal risk factors are of significance for development of TC in children and in young adults, and for seminomas and non-seminomas. The hypothesis that estrogens are involved in TC development was, among other factors, supported by the association of parity to TC. Additionally, on the basis of findings in maternal diseases and complications to pregnancy, we suggest that immune reactions during foetal life may be of significance for development of TC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008857702380
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  • 8
    Electronic Resource
    Electronic Resource
    Metastatic testicular cancer and extragonadal germ cell tumor presenting with neurological symptoms (1990)
    Springer
    Journal of neuro-oncology 8 (1990), S. 145-148 
    Details
    ISSN: 1573-7373
    Keywords: testicular neoplasms ; neurological symptoms ; brain tumors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We present two patients with testicular cancer and extragonadal germ cell tumor respectively in whom neurological symptoms due to metastases preceded the correct diagnosis. Testicular cancer and extragonadal germ cell tumor are today curable malignancies even when distant metastases are present at diagnosis. The diagnosis of germ cell tumor should be considered whenever a young man presents with metastases of uncertain origin, and all histological specimens should be revised with the diagnosis of germ cell tumor in mind.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00177837
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  • 9
    Electronic Resource
    Electronic Resource
    Serum lactate dehydrogenase (S-LDH) and S-LDH isoenzymes in patients with testicular germ cell tumors (1983)
    Springer
    Molecular genetics and genomics 189 (1983), S. 326-333 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The activities of serum lactate dehydrogenase (S-LDH) and S-LDH isoenzymes were determined in 252 patients with a history of testicular germ cell tumors (TGCT). Fifteen of 37 patients with TGCT lesions and seven of 215 without had raised levels of S-LDH (above 8.0 μkat/l (480U/l)). Of the patients with TGCT lesions, four had only raised S-LDH-1 levels, one only raise S-LDH-2 (and normal S-LDH), two only raised S-LDH-3 (one with normal S-LDH), and 10 had five combinations of raised levels of S-LDH isoenzymes with a predominance of S-LDH-1. S-LDH and S-LDH-1 correlated significantly with the total tumor volume in the patients with TGCT lesions, especially pronounced in those with lesions from seminoma. Of 34 patients with TGCT metastases, 13 with raised S-LDH levels lived significantly shorter lengths of time than 21 with normal S-LDH. Similarly, 11 with raised S-LDH-1 (above 3.0 μkat/l (180 U/l)) lived significantly shorter times than 23 with normal S-LDH-1. S-LDH is a valuable tumor marker in patients with TGCT, especially in those with seminoma. Routine determination of S-LDH isoenzymes in addition to S-LDH in patients with TGCT is not recommended. In patients with a history of TGCT and an unexplained elevation of S-LDH levels, a raised S-LDH-1 level indicates the presence of TGCT lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00337825
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