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  • 1
    Electronic Resource
    Electronic Resource
    METABOLISM OF POLYAMINES IN NORMAL AND SCRAPIE-AFFECTED MOUSE BRAIN AND SPLEEN (1972)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 19 (1972), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Following intracerebral inoculation of mouse adapted scrapie agent into mice, polyamine concentration in the brain decreases to about 75 per cent of the normal level during the first 2 months after intracerebral inoculation of the agent. Between 2 and 4 months after infection thelevel of spermidine and spermineincreased by 80 and 40 percent respectively to reach concentrations of 25 and 20 per cent higher than controls of the same age. During the same period the rate of incorporation of [14C]putrescine into spermidine is increased four-fold as compared with controls. The changes in polyamine levels correlate well with the pattern of astrocyte hypertrophy and are similar to those reported for human brain tumours. The concentration of polyamines in spleen increases soon after inoculation. Whilst changes in brain polyamines might be referred to the hypertrophic growth of astrocytes those in spleen are perhaps due to an increased metabolic activity of spleen cells associated with the replication of the agent. These results are derived from experimental mouse scrapie and not naturally occurring disease in sheep.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1972.tb01335.x
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  • 2
    Electronic Resource
    Electronic Resource
    HeLa (1973)
    [s.l.] : Nature Publishing Group
    Nature 242 (1973), S. 356-356 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR,-I was pleased to read J. Douglas's question, "Who was HeLa?" (Nature, 242, 144 ; 1973). I came across a poem by Nancy L. Caroline called "To Helen Larson" (Perspectives in Biology and Medicine, 15, 1971). It ends: - Then Helen Larson wed. Her groom Was cancer. Soon she felt Death stirring ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/242356a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Scrapie Agent and Neurones (1972)
    [s.l.] : Nature Publishing Group
    Nature 240 (1972), S. 106-107 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] During careful search in the brain of the scrapie rat granular inclusion bodies were seen in the cytoplasm of apparently normal neurones and their axons in the sites studied; the cortex, Ammon's horn and thalamus. At high magnification these uninteresting neuronal inclusions comprised very large ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/240106a0
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Axons from eyes grafted in Xenopus can grow into the spinal cord and reach the optic tectum (1978)
    [s.l.] : Nature Publishing Group
    Nature 275 (1978), S. 746-748 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 Tadpole of Xenopus laevis with a third eye grafted at embryonic stage 23 (ref. 13) and now (stage 58) growing above the spinal cord. The brain and the normal eyes with their optic nerves can be seen through the transparent tissue of the tadpole head. Embryos were obtained in our laboratory ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/275746a0
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    Paper (German National Licenses)
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