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  • 1
    Electronic Resource
    Electronic Resource
    Increased histidine decarboxylase (HDC) activity in human colorectal cancer: Results of a study on ten patients (1988)
    Springer
    Inflammation research 23 (1988), S. 357-360 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Following numerous reports of high histidine decarboxylase (HDC) activity in tumour-bearing animals, the present work was designed to determine the activity of this enzyme in normal and tumour tissues in a series of ten surgical patients with colorectal carcinoma. Significantly increased HDC activity, almost double that of normal tissues, was found in specimens from extirpated human tumours. These results, obtained under reliable sampling and measurement conditions indicated that changes in the enzymic activity of HDC may have a significant role in the development of colorectal tumour cells. Inhibition of the enzyme activity in human cancer subjects may retard or impede tumour growth and perhaps limit the spread of metastases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02142587
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Histamine and serotonin inhibit induction of ornithine decarboxylase by ornithine in perifused Ehrlich ascites tumour cells
    Amsterdam : Elsevier
    FEBS Letters 250 (1989), S. 257-261 
    Details
    ISSN: 0014-5793
    Keywords: Histamine ; Ornithine decarboxylase ; Perifusion ; Serotonin
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(89)80733-1
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  • 3
    Electronic Resource
    Electronic Resource
    Simultaneous fluoremetric determination of intracellular polyamines separated by reversed-phase high-performance liquid chromatography (1992)
    Springer
    Inflammation research 36 (1992), S. 17-21 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A reversed-phase HPLC technique in combination with fluorescent detection is described for simulataneous quantification of the precolumn Dansyl derivatives of intracellular amines. The derivatives were stable for at least one week, kept protected from the light at −20 °C. The detection limit was between 1 and 5 pmol for all tested polyamines. Serotonin coeluted with tryptamine. The method has a very good reproducibility for both, retention times and chromatographic peak areas. The average recovery of standard amine solutions added to cellular extracts was estimated to be higher than 90%. The described method enables a rapid, reliable and reproducible quantification of biogenic and related polyamines in biological fluids and tissues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01991222
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  • 4
    Electronic Resource
    Electronic Resource
    Polyamine metabolism regulation by histamine and other biogenic amines in Ehrlich carcinoma cells (1992)
    Springer
    Inflammation research 36 (1992), S. C380 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Polyamines feed-back regulate ornithine decarboxylase activity (ODC). Histamine, serotonin and cadaverine (amino acid decarboxylase products) somehow mimic the role known for polyamines. Serotonin, tryptamine, histamine and its analog chlorpheniramine inhibited the ODC induction caused by 0.5 mM ornithine. The presence of these diamines in the perfusion medium at 55 μM reduced the intracellular concentrations of ornithine. Results on intracellular concentrations of histamine, cadaverine and putrescine after different perifusion conditions suggest that a metabolic interplay could be involved between these biogenic amines, since the cell accumulation of one of them led to an increase in the intracellular concentrations of the others.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01997379
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  • 5
    Electronic Resource
    Electronic Resource
    Changes in histamine synthesis, tissue content and catabolism in human breast cancer (1989)
    Springer
    Inflammation research 27 (1989), S. 227-231 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The present study in 10 breast cancer patients supports the concept that newly synthetized, nascent histamine is involved in tumour growth. Histidine decarboxylase (HDC) activity is increased in mammary tumour tissue compared to healthy mammary gland-, skin- and muscle tissue in all but one patient studied. The newly formed histamine is probably not stored in the tumor tissue. Significantly decreased histamine concentrations were measured in parallel samples in the tumour tissue. Moreover, the preliminary results from urinary analysis of histamine and Nτ-methylhistamine in 3 of the 10 patients studied showed a significant decline after tumour extirpation compared to preoperative values.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02222247
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  • 6
    Electronic Resource
    Electronic Resource
    Common bile duct stones after laparoscopic cholecystectomy and its treatment (1994)
    Springer
    Surgical endoscopy and other interventional techniques 8 (1994), S. 1182-1185 
    Details
    ISSN: 1432-2218
    Keywords: Laparoscopic cholecystectomy ; Common bile duct stones ; Intravenous cholangiography ; Intraoperative cholangiography ; ERCP ; Transparietohepatic cholangiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the present work we recount our experience in handling common bile duct stones (CBDS) in our first 100 cases of laparoscopic cholecystectomy. In the first 50 cases our diagnostic procedures involved the use of ultrasound exploration and intravenous cholangiotomography 48 h before laparoscopic surgery. We found three cases of residual CBDS. One of the cases was treated by means of ERCP. The other two cases were resolved by carrying out a transparietohepatic cholangiography after the ERCP procedure failed. After this experience, we changed our strategy, introducing the intraoperative cholangiography in the cases with an unclear diagnosis. With this new approach, no residual CBDS occurred in the following 50 cases. These findings demonstrate the following: (1) In our hands, intravenous cholangiography is not more effective than ultrasound exploration in resolving dubious cases. (2) These dubious cases are more effectively diagnosed by means of selective intraoperative cholangiography. (3) When CBDS is treated by transparietohepatic cholangiography it proves to be less uncomfortable for the patient than ERCP and, as we found, even more efficient in removing the stones, although our experience is based on only two cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00591046
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  • 7
    Electronic Resource
    Electronic Resource
    The evolution of postoperative ileus after laparoscopic cholecystectomy (1993)
    Springer
    Surgical endoscopy and other interventional techniques 7 (1993), S. 416-419 
    Details
    ISSN: 1432-2218
    Keywords: Postoperative ileus ; Laparoscopic cholecystectomy ; Sympathetic blockade
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Our study is prompted by the arrival of laparoscopic cholecystectomy in connection with the evolution of postoperative ileus (PI) and by its avoidance of the intraabdominal handling implied in conventional cholecystectomy. With this aim a prospective, controlled, randomized, and blind clinical trial was designed using 100 patients divided into five groups (n=20): I, conventional cholecystectomy (CC); II, CC + injection of 20 ml bupivacaine 0.5% into the mesentery root; III, CC + 7.5 mg propanolol i.v. and 0.5 mg neostigmine s.c., postoperatively until the first defecation; IV, II + III; and V, laparoscopic cholecystectomy. The shortest period of PI was observed in group V. This period increases notably in group IV (53 h), group II (72 h), and group III (84 h) relative to the control group with (89 h). This reduction in PI time runs parallel with an improvement in the patient's general state of well-being. We concluded that after laparoscopic cholecystectomy PI is nonexistent. Furthermore, this study confirms the correlation between the avoidance of intraabdominal manipulation and the evolution of postoperative ileus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311733
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