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  • 1
    Electronic Resource
    Electronic Resource
    Perforated jejunal diverticulitis as a rare cause of acute abdomen (1999)
    Springer
    European radiology 9 (1999), S. 1426-1428 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Diverticulitis ; Perforation ; Jejunum ; Acute abdomen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Jejunal diverticula is rare and in most cases without any symptoms. They become clinically relevant when complications, such as diverticulitis, malabsorption caused by bacterial overgrowth, intestinal hemorrhage, or obstruction, occur. In this case report a case of perforated jejunal diverticulitis is presented and the problems in finding the correct diagnosis are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050862
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  • 2
    Electronic Resource
    Electronic Resource
    P53 accumulation in precursor lesions and early stages of bladder cancer (1994)
    Springer
    World journal of urology 12 (1994), S. 79-83 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recent investigations have demonstrated alterations of the p53 tumor-suppressor gene in a considerable number of transitional-cell carcinoma (TCC) specimens. Thus far, these investigations have been restricted to either papillary TCC or invasive bladder cancer. To obtain further information on a possible involvement of p53 in bladder cancer development or tumor progression, investigations of precursor lesions and early stages of this disease are required. Immunohistochemical examination of 6 dysplasias and 24 carcinomas in situ (TIS) showed p53 accumulation, which is suggestive of p53 inactivation, in 2 (33%) and 9 (38%) of these specimens, respectively. This ratio was similar in 9 T1 lesions (33%) and in 14 cases of muscle-infiltrative disease (35%). In papillary tumors, p53 accumulation was observed exclusively in 3/10 moderately differentiated or high-grade lesions but not in 1 Ta G1 tumor. The expression of p53 accumulation was a consistent finding. The examination of tumor recurrences yielded either the presence or the absence of p53 overexpression in the primary and recurrent tumors of 7/8 patients. Similarily, in multifocal TCC, p53 accumulation was also either present or absent in 10/11 cases examined. These results suggest the existence of at least two different subgroups of TCC, with p53 accumulation being present in one of these groups. The observation of p53 accumulation in dysplasia and in TIS is a prerequisite for a possible involvement of p53 in bladder cancer carcinogenesis, although it does not prove this assumption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00184241
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  • 3
    Electronic Resource
    Electronic Resource
    Cytomorphological, cytogenetic, and molecular biological characterization of four new human renal carcinoma cell lines of the clear cell type (1994)
    Springer
    Virchows Archiv 424 (1994), S. 403-409 
    Details
    ISSN: 1432-2307
    Keywords: Human renal cell carcinoma ; Cell line ; Proto-oncogene ; Tumour suppressor gene ; p53
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Four new permanent cell lines (RCC-A, -B,-C, and -D) derived from different human renal cell carcinomas of the clear cell type were established in tissue culture. The cell lines displayed characteristic differences in cell size and shape, which allowed individual identification by phase contrast microscopy. Ultrastructurally, the cell lines exhibited varying amounts of cytoplasmatic glycogen and lipid. Immunohistochemistry revealed co-expression of vimentin and cytokeratin in all cell lines. The mean population doubling time ranged from 27 h (RCC-A) to 104 h (RCC-D). RCC-B and -C cells produced slowly growing tumours after heterotransplantation into nude mice, whereas RCC-A and RCC-D cells were non-tumorigenic. The modal chromosome number was either near-diploid (RCC-A, -B, and -C) or near triploid (RCC-D). Clonal abnormalities affecting the short arm of chromosome 3 were seen in all cell lines. Northern blot analysis revealed no expression of the proto-on-cogenes c-fos, c-ros, and c-mos, whereas c-Ki-ras expression was observed in all cell lines. Expression of c-myc was observed in RCC-A, RCC-B, and RCC-D cells, whereas c-raf expression could be detected in RCC-B and RCC-D. Tumour suppressor gene p53 mRNA was observed in the cell line RCC-D.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00190563
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  • 4
    Electronic Resource
    Electronic Resource
    Modulation of invasive potential in different clonal subpopulations of a rat rhabdomyosarcoma cell line (BA-HAN-1) by differentiation induction (1993)
    Springer
    Clinical & experimental metastasis 11 (1993), S. 55-67 
    Details
    ISSN: 1573-7276
    Keywords: differentiation induction ; retinoic acid ; rhabdomyosarcoma ; tumor heterogeneity ; tumor invasion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Three clonal subpopulation (A, B, C) isolated from the same rhabdomyosarcoma of the rat and differing in their degree of spontaneous differentiation were tested for their invasive potential before and after differentiation induction with retinoic acid (RA), N-monomethylformamide (NMF) and sodium butyrate (NaBut). Invasive potential was analysed in anin vitro assay using embryonic chick heart fragments in organotypic culture. In standard culture medium, all three subpopulations were shown to be invasive, progressively replacing the chick heart fragments within 7–11 days after confrontation. After exposure to RA, NMF or NaBut, marked differences in the invasive potential of these subpopulations were, however, observed. Subpopulation C exhibited a pronounced decline in invasive potential, as evidence by a significant decrease (P = 0.005) in the proportion of chick heart fragments with advanced stages of invasion. This response, however, was confined to the differentiation-inducing agents RA and NaBut, which had also produced a marked increase in morphological and/or biochemical differentiation (P = 0.0001). In contrast, NMF, which had only minor effects on differentiation, failed to affect the invasive potential of subpopulation C. In subpopulation B, a transient inhibition of single cell invasion became evident after exposure to RA, whereas NMF and NaBut failed to affect the invasive potential in spite of minor effects on differentiation. In the least differentiated subpopulation A, which was shown to be refractory to the differentiation-inducing effects of RA, NMF and NaBut, there was also no observation of any reduction of invasive potential. The results of our study demonstrate that differentiation-inducing agents can significantly reduce the invasive potential of malignant tumors, although marked differences of response are to be expected between the different subpopulations of a tumor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00880066
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  • 5
    Electronic Resource
    Electronic Resource
    Etablierung und Charakterisierung von 6 humanen Ovarialkarzinomlinien (1987)
    Springer
    Archives of gynecology and obstetrics 242 (1987), S. 457-458 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01783211
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  • 6
    Electronic Resource
    Electronic Resource
    Solitäres Rektumulkus als Ursache peranaler Blutungen bei Kindern (1998)
    Springer
    Monatsschrift Kinderheilkunde 146 (1998), S. 105-109 
    Details
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Solitäres Rektumulkus ; Gastrointestinale Blutungen ; Rezidivierende Analschmerzen ; Mukosaprolapssyndrom ; Key words Solitary rectal ulcer syndrome ; Gastrointestinal bleeding ; Recurrent anal pain ; Mucosal prolapse syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary We report on an 8 year old boy and a 12 year old girl with intermittent peranal loss of blood and mucus, impaired defecation and recurrent abdominal pain. On endoscopy isolated ulcers were seen in the rectum only, whereas the colonic mucosa appeared to be normal macroscopically and microscopically. Biopsies from the borders of the ulcers revealed a hyperplasia of the lamina muscularis mucosae and a fibromuscular obliteration of the lamina propria mucosae. These clinical, endoscopical and histological findings are characteristic for the solitary rectal ulcer syndrome. Only 26 paediatric cases (age at diagnosis 6–9 years) have been published so far. The interval from first symptoms to final diagnosis (mean: 3,7 years, range: 1 week to 9 years) is remarkably long in childhood cases. Pathogenetically an internal rectal prolapse with secondary ischemic lesions is assumed. There is no evidence of an association to inflammatory bowel disease. The ulcers ars often resistant to different medical and surgical options. Discussion: Pediatricians should be aware of the solitary rectal ulcer syndrome in order to make an earlier diagnosis and to prevent unnecessary diagnostic procedures and concerns of patients and their parents about more severe illnesses.
    Notes: Zusammenfassung Wir berichten über einen 8jährigen Jungen und ein 12jähriges Mädchen mit seit Jahren bestehenden, intermittierenden rektalen Blut- und Schleimabgängen, Stuhlentleerungsstörungen und rezidivierenden Bauchschmerzen. Endoskopisch fanden sich isolierte Ulzera im Rektum bei sonst makroskopisch und mikroskopisch normaler Schleimhaut im übrigen Kolon. Am Ulkusrand entnommene Biopsien zeigten eine Hyperplasie der Lamina muscularis mucosae und eine fibromuskuläre Obliteration der Lamina propria. Die histologischen Veränderungen in Kombination mit den klinischen Beschwerden und dem endoskopischen Bild führten zur Diagnose eines solitären Rektumulkus. Eine Literatursuche ergab nur 26 publizierte Fälle mit solitärem Rektumulkus im Kindes- und Jugendalter (Alter bei Diagnosestellung: 6–19 Jahre). Das Intervall zwischen dem Beginn der Symptomatik und der Diagnose betrug im Schnitt 3,7 Jahre (Spanne 1 Woche–9 Jahre). Pathogenetisch wird ein innerer Prolaps mit ischämischer Wandschädigung angenommen. Eine Be-ziehung zum Morbus Crohn und zur Colitis ulcerosa besteht nicht. Die Therapiemöglichkeiten sind unbefriedigend, Rezidive häufig. Diskussion: Eine frühzeitige Diagnose des in der Pädiatrie wenig bekannten Krankheitsbilds könnte den Kindern unnötige diagnostische Untersuchungen und Sorgen vor ernsthaften Erkrankungen ersparen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001120050252
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  • 7
    Electronic Resource
    Electronic Resource
    Age-dependent shift-to-the-right in the localization of colorectal adenomas (1987)
    Springer
    Virchows Archiv 411 (1987), S. 591-598 
    Details
    ISSN: 1432-2307
    Keywords: Adenoma ; Colorectal ; Prevalence ; Topographical distribution ; Colorectal carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The age-dependent prevalence and topographical distribution of colorectal adenomas was investigated in 1006 unselected autopsies (554 males and 452 females) in Mainz, FRG. In 200 out of 1006 autopsies (19.8%) a total of 498 adenomas of the large intestine were detected. The percentage of patients with adenomas increased continuously with age. Only 6% of all adenomas were localized in the caecum and 8% in the rectum, whereas all the other adenomas were distributed rather evenly throughout the ascending colon (23%), the transverse colon (25%), the descending colon (15%) and the sigmoid colon (23%). Analyzing the topographical distribution of adenomas for definite age groups (40-59, 60-69, 70-79 and 80-99 years of age), it became evident that the topographical distribution is not constant, but shows an age-dependent shift-to-the-right, i.e. with advancing age an increase in the relative frequency of adenomas in the proximal colonic segments (from caecum to transverse colon) and a decrease in the distal segments (from descending colon to rectum). This shift to the right, which evolves continuously from the youngest to the oldest age group, results from a disproportionate increase in the absolute number of adenomas in the proximal colonic segments when compared with the distal segments. The age-dependent shift-to-the-right of colorectal adenomas provides an important confirmation of the adenoma-carcinoma sequence, but cannot be explained by current concepts concerning the aetiology of colorectal adenomas and carcinomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00713291
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  • 8
    Electronic Resource
    Electronic Resource
    Laser welded vascular anastomosis (1988)
    Springer
    Urological research 16 (1988), S. 127-131 
    Details
    ISSN: 1434-0879
    Keywords: Microsurgery ; CO2 laser ; Neodymium Yag laser ; Vascular anastomosis ; Rat ; Tensile strength ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A comparative study was undertaken to investigate the application of a specially adapted microsurgical Neodymium Yag Laser system with a wavelength of 1,319 μm and a CO2 laser system for laser assisted microvascular end-to-end anastomosis (LAMA) of the rat femoral artery. Conventionally sutured anastomoses served as controls. Postoperative investigations included patency tests, light microscopy and tensile strength measurements. Both laser systems seem to be equally suitable for LAMA: The patency rates do not differ from those of sutured anstomoses and formation of microscopically small aneurysms occurred predominantly in control animals and only once in laser groups. The clamp time needed for LAMA was half the time that was needed for sutured anastomoses. Wound healing in all groups was similar with less fibrotic reactions and less foreign body granulomas in laser groups. At all intervals tensile strength was significantly higher for sutured anastomoses while differences between the CO2- and the ND: Yag-laser groups were not statistically significant. Potential applications in urology include microvascular anastomoses in erectile dysfunction, pediatric and reconstructive urology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00261970
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  • 9
    Electronic Resource
    Electronic Resource
    CO2 and Nd:YAG laser systems in microsurgical venous anastomoses (1991)
    Springer
    Urological research 19 (1991), S. 253-257 
    Details
    ISSN: 1434-0879
    Keywords: Microsurgery ; CO2 laser ; Nd:YAG laser ; Rat ; Vascular anastomosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A comparative study was undertaken in 81 rats to investigate a CO2 and Nd:YAG laser system for laserwelded anastomosis of the femoral vein. Conventionally sutured anastomoses (CMSA) served as controls. Laserwelded anastomosis (LAMA) was easier and could be performed 30% faster than CMSA. Postoperative investigations included patency tests, postmortem examinations and light and electron microscopy. Aneurysms were not seen. Foreign-body reaction was more pronounced in CMSA. Patency rates for CO2-LAMA and CMSA were equal, whereas Nd:YAG-LAMA resulted in significantly higher rate of early postoperative thrombosis (P〈0.01). Because of its physical properties, the CO2-laser system seems to be better suited for laser welding of delicate structures such as the rat femoral vein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00305306
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  • 10
    Electronic Resource
    Electronic Resource
    c-myc in bladder cancer Clinical findings and analysis of mechanism (1997)
    Springer
    Urological research 25 (1997), S. S45 
    Details
    ISSN: 1434-0879
    Keywords: c-myc ; Protooncogene ; Bladder cancer ; Dysplasia ; Carcinoma in situ ; Cell proliferation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The c-myc gene product is known to be involved in the regulation of cell proliferation and differentiation. Altered c-myc gene expression is a common event in a variety of tumors. This study was designed to investigate c-myc overexpression in transitional cell carcinoma (TCC). The first part was designed to investigate the frequency of c-myc overexpression in relation to tumor stage and tumor grade. A second set of experiments was directed at the mechanisms underlying c-myc overexpression in TCC. A total of 185 paraffin-embedded urothelial tissue specimens were investigated immunohistochemically for c-myc overexpression. A single case of overexpression (6%) was observed in normal urothelial tissue (n=16). c-myc overexpression was also infrequent in carcinoma in situ (TIS) (7/39=18%). In contrast, papillary urothelial tumors (n=65) yielded c-myc overexpression in 38 cases (58%). Investigation of infiltrating bladder tumors revealed c-myc overexpression in 56% of T1 tumors and 59% of muscle-infiltrating tumors. The staining pattern in multifocal tumors was heterogeneous in 10 of 18 cases. Similarly, only 12 of 28 patients with tumor recurrences showed the same c-myc staining pattern in the primary tumorand in tumor recurrences. c-myc overexpression did not correlate with tumor grade or tumor progression. Nevertheless, the high frequency of c-myc overexpression in urothelial carcinoma suggests an important role for this protein in urothelial carcinoma. Therefore, the mechanism underlying c-myc overexpression was further investigated in six bladder carcinoma cell lines. Southern blot experiments under standardized conditions showed no significant gene amplification. The comparison of c-myc mRNA expression to that of histoneH3 as a measure of cell proliferation revealed a moderate correlation (r=0.45) in the six cell lines examined. These data suggest that in accord with its established role as a cell cycle competence factor, c-myc may be necessary but not sufficient for the induction of proliferation in urothelial carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00942047
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