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  • 1
    Electronic Resource
    Electronic Resource
    Sodium-potassium-ATPase activity in the dorsal root ganglia of rats with streptozotocin-induced diabetes (1985)
    Springer
    Diabetologia 28 (1985), S. 104-107 
    Details
    ISSN: 1432-0428
    Keywords: Sodium-potassium-ATPase ; dorsal root ganglia ; streptozotocin diabetes ; diabetic neuropathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sodium-potassium-ATPase activity was measured in excised dorsal root ganglia of streptozotocin-diabetic rats, 2 months after induction of diabetes. In comparison with agematched controls, there was a decrease in both the total and ouabain-insensitive activity, indicating an overall reduction in ouabain-sensitive activity of 46%. This decrease may explain the reduced amino-acid uptake exhibited by diabetic sensory ganglia and could be relevant to the development of diabetic neuropathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00279925
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  • 2
    Electronic Resource
    Electronic Resource
    High-resolution Observations of the Galactic Radiation at 4.7 Mc/s (1963)
    [s.l.] : Nature Publishing Group
    Nature 197 (1963), S. 475-476 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The antenna system was a filled-in array 4,000 ft. east-west by 1,000 ft. north-south. It was connected to receivers in which the signals were added in six independent phase arrangements in such a way that the intensity of the cosmic noise at six declinations could be recorded simultaneously. The ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/197475a0
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  • 3
    Electronic Resource
    Electronic Resource
    An unusual cause of postpartum collapse or a red herring? (2003)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 58 (2003), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2044.2003.03095_22.x
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  • 4
    Electronic Resource
    Electronic Resource
    Rituximab for autoimmune haemophilia: a proposed treatment algorithm (2005)
    Oxford, UK : Blackwell Science Ltd
    Haemophilia 11 (2005), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary.  We previously reported durable complete responses following brief courses of rituximab and prednisone with or without cyclophosphamide in four patients with autoimmune haemophilia and inhibitor titres of 5–60 BU. We report here responses to this monoclonal anti-CD20 antibody in four additional patients, including two patients with inhibitor titres 〉200 BU. Factor VIII levels became normal 2–35weeks after 4 or 8 weekly doses of rituximab, brief courses of prednisone and in one patient immunoglobulin. Complete responses are ongoing at 10 months in two patients. Two patients relapsed: a patient whose initial inhibitor titre was 525 BU relapsed at 3.5 months and a long-term prednisone-dependent patient at 8.5 months. Both responded to second courses of rituximab and prednisone and are in remission. Our experience suggests that rituximab is a safe and effective addition to immunosuppression with prednisone and cyclophosphamide to treat autoimmune haemophilia, and may permit early discontinuation or even avoidance of these potentially toxic agents. High-titre inhibitor patients, however, may require multiple courses of rituximab or the addition of cyclophosphamide. Pending randomized studies, we propose an algorithm based on our experience and other reports for incorporating rituximab in the treatment of this rare disorder.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2516.2005.01060.x
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  • 5
    Electronic Resource
    Electronic Resource
    Immunolocalization of platelet-derived growth factor A and B chains and PDGF-α and β receptors in human gingival wounds (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 32 (1997), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Platelet-derived growth factor (PDGF) is a polypeptide growth factor which has been implicated as a major mitogen involved in wound healing. The PDGF appears to promote periodontal regeneration; however, its distribution in gingival tissues is not known and how it participates in gingival wound healing is unclear. Using highly specific antibodies we have studied the distribution of PDGF A and B chains and α- and β-PDGF receptors in healing human gingival wounds. Wounds were created by making a 0.75 mm deep incision in the papilla of healthy human gingiva and biopsies were obtained from the same site after 8 h and 1, 3, 7, 14 and 21 d. Frozen sections were immunostained with affinity purified antibodies. The results showed that both epithelium and fibrin clot manifested positive immunostaining for anti-PDGF-A and B-chain antibodies. Staining was present in unwounded and wounded epithelia, and in the fibrin clot it appeared to be more intense for the PDGF-A chain. Blood vessels in connective tissue were also positive while other areas were largely negative. No significant staining was detectable in healthy tissues for anti-PDGF-α or -β receptor antibodies. However, the wound site began to manifest positive immunostaining for anti-β-receptor antibody after 3 d of healing, became maximal at 7d, and then decreased. Our data indicate, but do not prove, that gingival epithelium may be a source of PDGF A and B chains and that the A chain may have a more prominent role to play during early stages of healing. Expression of PDGF β-receptor appears later at the wound site, indicating that the PDGF B isomer may regulate later wound healing events.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1997.tb00526.x
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  • 6
    facet.materialart.
    Unknown
    Oscar Wilde's "Intentions": An Early Modernist Manifesto (1973)
    Oxford : Periodicals Archive Online (PAO)
    The British Journal of Aesthetics. 13:4 (1973:Autumn) 397 
    Details
    ISSN: 0007-0904
    Topics: Art History
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:c362-1973-013-04-000007
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  • 7
    Electronic Resource
    Electronic Resource
    Burning plastics: Mechanisms of smoke formation (1976)
    New York, NY [u.a.] : Wiley-Blackwell
    Fire and Materials 1 (1976), S. 36-41 
    Details
    ISSN: 0308-0501
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Architecture, Civil Engineering, Surveying , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Quantitative pyrolysis gas chromatography studies have been conducted on three grades of cross-linked polyester resin formulated for improved resistance to surface spread of flame. Pyrolysis temperatures from 723 to 1273 K were used, and these values correspond to ‘surface’ temperatures of materials exposed to heat fluxed of 15-149 kW m-2 which are typical of conditions experienced in real fires. Comparison is made with earlier macro studies on the evolution of smoke from plastics materials exposed to similar heat fluxes under an inert atmosphere. There is some correlation between the smoke obscuration data obtained in previous macro studies and the yield of volatile aromatic products evolved on pyrolysis. The presence of flame retardants increases the formation of carbon in the pyrolysis residue and decreases the yield of volatile aromatic products isolated. The results are considered in the context of mechanisms of smoke formation.
    Additional Material: 6 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/fam.810010109
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  • 8
    Electronic Resource
    Electronic Resource
    A surface plasmon resonance study of albumin adsorption to PEO-PPO-PEO triblock copolymers (1998)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 42 (1998), S. 165-171 
    Details
    ISSN: 0021-9304
    Keywords: surface plasmon resonance ; atomic force microscopy ; protein adsorption ; block copolymer ; Pluronics ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Pluronic surfactants, PEO-PPO-PEO triblock copolymers, have been investigated widely due to their protein-resistant properties in applications as coatings for implants and in controlled drug release systems. We have studied a wide range of these copolymers, varying in both PEO and PPO block size, by adsorbing them to a polystyrene surface and investigating their subsequent resistance to human serum albumin adsorption. This investigation has been carried out in real time, using surface plasmon resonance, with the surfaces subsequently visualized by atomic force microscopy. This approach has allowed determination of the effect of the lengths of the PEO and PPO polymer chains on protein resistivity. For low-molecular-weight Pluronics a significant, yet not complete, reduction in albumin adsorption has been observed whereas higher molecular weight Pluronics appear to completely inhibit adsorption within the time frame of this experiment. An increase in the PPO block size of the copolymer also appears to increase its protein resistance. This work further confirms that the binding strength of the anchoring block to the hydrophobic surface, rather than the length of the protruding hydrophillic PEO chains, determines a copolymer's protein resistance capability. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 42, 165-171, 1998.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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