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  • 1
    ISSN: 1432-0533
    Keywords: Brain tumors ; Cell cultures ; Prostaglandins ; Immunomodulating factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cultured human glioma cells were found to produce soluble factors that can modulate the in vitro proliferative response of purified T lymphocytes stimulated by phytohemagglutinin (PHA). Neoplastic tissue was removed during surgery for brain glial tumors and cultured in vitro. The glial nature of the neoplastic cells was verified by means of anti-glial fibrillary acidic protein immunohistochemical staining. Serum-free supernatants from these cultures proved capable of suppressing in vitro proliferation of PHA-stimulated T lymphocytes. Suppression was reduced when indomethacin or aspirin was added to the culture medium. Thin-layer chromatography revealed the presence of prostaglandins and other arachidonic acid derivatives in the supernatants. The radioimmunoassay used to quantify the prostaglandin E2 (PGE2) in the supernatants showed detectable amounts of PGE2, which disappeared after the cultures had been treated with anti-inflammatory drugs. These data support the hypothesis that tumoral glial cells can play a role in the host immune response in the central nervous system, namely by producing soluble factors.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0533
    Keywords: Humoral immune response ; Glioma antigens ; Ultrastructural localization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Several human cell lines (normal and neoplastic glia, cerebral metastases from adenocarcinoma, fibroblasts) were incubated with sera from patients with well and poorly differentiated glioma and with sera from healthy donors and then stained with PAP complex to define and localize the antibody reaction with cell surface antigens by means of electron microscopy. The sera of glioma patients proved to contain antibodies which bound the tumor-associated antigenic determinants on the cell membranes of gliomas and of cerebral metastases from adenocarcinoma in tissue cultures. Further, absorption testing of the reactive sera on normal brain, well-differentiated astrocytoma and cultured glioblastoma cells, together with cross-reactivity experiments suggests that at least two antigens or groups of antigens are expressed on the glioma cell surface: one shared by well and poorly differentiated glioma cells and the other by poorly differentiated glioma cells and the cells of cerebral metastases from adenocarcinoma.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 18 (1968), S. 259-267 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Autoren bringen eine Analyse von 100 Fällen mit idiopathischem Pseudotumor cerebri (ätiologisch ungeklärte intrakranielle Drucksteigerung). Die klinischen und Laborbefunde werden kurz beschrieben. Die Befunde werden mit entsprechenden Befunden des Schrifttums verglichen. Die verschiedenen therapeutischen Möglichkeiten werden zusammengefaßt. 81 Fälle der Serie konnten für einen Zeitraum von 3 Monaten bis zu 10 Jahren nachbeobachtet werden. Bei 80 von ihnen war der Verlauf günstig, unabhängig von der durchgeführten Behandlung. Auf Grund einer Auswertung von 36 Fällen betrug die durchschnittliche Dauer des Syndroms 10 Wochen.
    Abstract: Résumé Les auteurs font l'étude de 100 cas de pseudo-tumeur cérébrales idiopathiques (hypertension intracrânienne cryptogénétique). Le syndrome clinique et les examens de laboratoire complémentaires sont ensuite analysés et comparés à ceux de cas similaires rapportés dans la littérature. Les hypothèses variées sur pathogénie du syndrome et le traitement sont ensuite discutées. Sur les 100 cas, 81 peuvent être suivis pour une période allant de 3 mois à 10 ans et l'évolution fut favorable chez 80 d'entre eux, quelle que fut la thérapeutique appliquée. Après analyse particulière de 36 cas, on a pu déclaré que la durée moyenne du syndrome était de 10 semaines.
    Notes: Summary 100 cases of idiopathic Pseudotumor cerebri (cryptogenetic intracranial hypertension) are analysed. The clinical and laboratory features are briefly described. The data are compared with similar data from the literature and the relevant therapeutic procedures are summarised. Of this series 81 cases were followed up for a period ranging from 3 months to 10 years. The course was favourable for 80 of them, irrespective of the treatment given. The average duration of the syndrome, on the basis of 36 cases, was 10 weeks.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 43 (1978), S. 153-162 
    ISSN: 0942-0940
    Keywords: Intracranial aneurysm ; subarachnoid haemorrhage ; intracranial haematoma ; spasm of cerebral vessels ; quality of survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A consecutive series of 200 patients with intracranial saccular aneurysms subjected to surgery with the aid of an operating microscope is presented.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird ein Bericht über 200 Fälle kindlichen, nicht tumorbedingten Hydrozephalus gegeben, die durch ventrikulovenösen shunt operiert wurden. Die präoperativen Untersuchungen, die Art des verwendeten Ventilsystems, die beobachteten Komplikationen und die Ergebnisse werden beschrieben. Es wird darauf hingewiesen, daß die rechtsseitige Brachialis-Angiographie in Ergänzung der Luftuntersuchungen des Ventrikelsystems für die Erkennung der Art des Hydrozephalus und für den Ausschluß einer Hydranenzephalie eine nützliche Untersuchungsmethode ist. Das Pudenz-Ventilsystem ohne Reservoir wird bevorzugt wegen einer geringen Häufigkeit von infektiösen Komplikationen. Unter den postoperativen. Komplikationen kam bei drei Fällen eine ungewöhnlich produktive Ependymitis vor, die zur Obliteration der Ventrikel führte. Die Langzeitergebnisse, gemessen an der psychomotorischen Entwicklung, waren bei mehr als 50% der Fälle ausgezeichnet oder gut.
    Abstract: Résumé Revue de 200 cas d'hydrocéphalie non tumorale opérées par dérivation ventriculo-atriale. Les examens préopératoires, le type de la valve employée, les complications observées, et les résultats sont exposés. L'angiographie rétrograde par voie brachiale droite est une technique souvent utilisée complétant les explorations par l'air, dans le diagnostic du type d'hydrocéphalie, et pour éliminer les cas d'hydro-anencéphalie. La valve de Pudenz sans réservoir est préférée à cause de la faible fréquence de complications. Dans les complications post-opératoires, on signale 3 cas d'obstruction ventriculaire par développement inhabituel de tissu épendymaire. Les résultats à long terme, évalués selon le développement psychomoteur sont excellents ou bons dans plus de 50% des cas.
    Notes: Summary 200 cases of infantile non tumoural hydrocephalus operated by ventriculo-venous shunt have been reviewed. The preoperative studies, the type of valve employed, the complications observed, and the results obtained are described. Retrograde right brachial angiography is emphasized as a useful technique, complementing air studies, in diagnosing the type of hydrocephalus and in excluding cases of hydranencephaly. The Pudenz valve without reservoir is preferred because of a low incidence of infective complications. Among the postoperative complications, an unusual productive ependymitis leading to obliteration of ventricles occurred in 3 cases. Long-term results, evaluated according to psychomotor development, show an incidence of excellent or good result in more than 50% of cases.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 29 (1973), S. 65-71 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A consecutive series of 98 patients with intracranial aneurysms subjected to surgery with the aid of an operating microscope is presented. Of the eighty Botterell grade 1-2-3 patients only two died, fiftysix made an excellent recovery, fifteen a good, and seven a fair recovery. The problem of Botterell grade 4–5 patients is discussed.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 24 (1971), S. 81-88 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 206 patients with Parkinson's disease have been treated with oral L-DOPA for periods ranging from three to twelve months. Marked or very marked improvement of bradykinesia, rigidity and tremor occurred respectively in 58.3%, 34.7% and 15% of the cases at the 3rd month of treatment; in 70.8%, 47.7% and 20% at the 6th month (80 cases); in 88%, 64.4% and 16.2% at the 9th month (34 cases). The degree of independence gained in overall behavioural performance has been recorded at three-monthly intervals and reported for the various forms of Parkinsonism (idiopathic 133 cases; arteriosclerotic 39 cases; postencephalitic 34 cases). About 78% of the patients experienced side-effects; all of them were reversible and not very important.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 85 (1987), S. 117-124 
    ISSN: 0942-0940
    Keywords: Pituitary adenomas ; transsphenoidal and transcranial approach
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Of the 510 patients with pituitary adenoma treated surgically at our hospital in the period 1956–1984 319 were treated by the microsurgical technique, in the period 1973–1984, 235 by transsphenoidal approach and 84 by subfrontal-pterional approach. The transsphenoidal route was used almost exclusively in microadenomas, in intrasellar adenomas, in suprasellar adenomas with midline development, in adenomas invading the sphenoidal sinus and in haemorrhagic adenomas with considerable suprasellar development. In some giant adenomas the transsphenoidal route was used in a first stage operation for debulking the tumour, later removed by transcranial route. The latter route was preferred in large adenomas and especially in adenomas with laterosellar development. In some patients with PRL secreting adenomas post-operative treatment with bromocriptine proved useful when the hormone levels failed to noramlize. Post-operative radiotherapy was of value in invasive adenomas and in cases in which tumour removal was not radical.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 17 (1967), S. 7-23 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Darstellung stützt sich auf eine Serie von 71 primären intramedullären Tumoren des Rückenmarks, die in einem Zeitraum von 15 Jahren immer von demselben Neurochirurgen operiert worden sind. Die Serie enthält 60 Gliome, 9 seltene Tumoren und 2 nicht klassifizierbare intramedulläre Tumoren. Indikationen und Kontraindikationen der chirurgischen Therapie werden besprochen.
    Abstract: Résumé Cette étude est basée sur 71 tumeurs primitives intra-médullaires opérées par le même chirurgien pendant une période de 15 ans. La série comprend 60 gliomes, 9 tumeurs rares et 2 non classées. Indications et contrindications du traitement chirurgical sont discutées.
    Notes: Summary This study is based upon 71 primary intramedullary tumours of the spinal cord operated upon by the same surgeon during a period of 15 years. The series includes 60 gliomas, 9 rare tumours and 2 non classified intra-medullary tumours. The indications and contraindications for surgical treatment are discussed.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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