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  • 1
    Electronic Resource
    Electronic Resource
    483 Estradiol (ER) and progesterone (PR) receptors in human spinal cord tumours
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 19 (1983), S. 166 
    Details
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-4731(83)91984-2
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  • 2
    Electronic Resource
    Electronic Resource
    The surgical treatment of choroid plexus papillomas (1981)
    Springer
    Neurosurgical review 4 (1981), S. 129-137 
    Details
    ISSN: 1437-2320
    Keywords: Choroid plexus papilloma ; Surgical treatment ; Surgical results ; Chorioid-Plexuspapillome ; Operative Behandlung ; Operative Ergebnisse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In der Arbeit wird über das operative Behandlungsergebnis von 27 Plexuspapillomen aus einer Serie von 28 Fällen berichtet, die zwischen 1952 und 1978 im Neurochirurgischen Institut der Universität Rom behandelt wurden. Eine Gliederung erfolgte in 2 Gruppen: a) vor 1969 und b) nach 1969 mit routinemäßiger Durchführung der Mikrochirurgie. Ventrikuläre Shunt-Operationen und Röntgentherapie wurden praeoperativ nicht vorgenommen. Eine Totalentfernung des Tumors wurde stets angestrebt und mit Ausnahme von 3 Fällen durchgeführt. In der mikrochirurgisch operierten Gruppe (1969–1978) war das Ergebnis deutlich besser. 92% wurden total extirpiert gegenüber 87% in der Gruppe a). Es verstarben postoperativ 16% gegenüber 31%. Die Spätergebnisse waren mit 67% besser als in der ersten Gruppe mit 44%. Insgesamt hatten 14 Kranke (55%) ein gutes Spätresultat mit Nachuntersuchungen nach 2 bis 27 Jahren. Die radikale Entfernung ist die Methode der Wahl in der Behandlung der Plexuspapillome. Die eigenen Erfahrungen zeigen, da– sie zu zufriedenstellendem Spätergebnis bei akzeptabler Operationsmortalität führt. Voraussetzung ist die Beherrschung der modernen Operationstechnik. Die Bedeutung der Radio-Therapie bleibt fraglich. Sie sollte ausschließlich auf maligne Fälle beschränkt bleiben.
    Notes: Summary This paper reports the results of 27 choroid plexus papillomas surgically treated, out of 28 cases observed in the authors insitute during the period 1952–1978. These were divided into two groups: a) those operated on before 1969; b) those operated on in 1969 and the following years, when microsurgical facilities were routinely employed. As a rule, neither ventricular shunting nor radiation therapy were used preoperatively. A total removal was attempted in all cases, and performed in all but three. The second group (1969–1978) showed better results as regards the number of totally removed tumours (92% against 87%), surgical deaths (16% against 31%), and long-term good results (67% against 44%). Considering both groups together, long-term good results were achieved in 15 patients (55%), followed up from 2 to 27 years. Radical operation is the treatment of choice for choroid plexus papilloma. As indicated by the author's experience, this produces satisfactory long-term results, whilst surgical mortality can be held within acceptable limits, provided that modern techniques are used properly. The value of radiation therapy, which in any event should be restricted to malignant cases, remains questionable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01743638
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  • 3
    Electronic Resource
    Electronic Resource
    Prostaglandin E2 as an immunomodulating factor released in vitro by human glioma cells (1986)
    Springer
    Acta neuropathologica 69 (1986), S. 278-282 
    Details
    ISSN: 1432-0533
    Keywords: Brain tumors ; Cell cultures ; Prostaglandins ; Immunomodulating factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cultured human glioma cells were found to produce soluble factors that can modulate the in vitro proliferative response of purified T lymphocytes stimulated by phytohemagglutinin (PHA). Neoplastic tissue was removed during surgery for brain glial tumors and cultured in vitro. The glial nature of the neoplastic cells was verified by means of anti-glial fibrillary acidic protein immunohistochemical staining. Serum-free supernatants from these cultures proved capable of suppressing in vitro proliferation of PHA-stimulated T lymphocytes. Suppression was reduced when indomethacin or aspirin was added to the culture medium. Thin-layer chromatography revealed the presence of prostaglandins and other arachidonic acid derivatives in the supernatants. The radioimmunoassay used to quantify the prostaglandin E2 (PGE2) in the supernatants showed detectable amounts of PGE2, which disappeared after the cultures had been treated with anti-inflammatory drugs. These data support the hypothesis that tumoral glial cells can play a role in the host immune response in the central nervous system, namely by producing soluble factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688305
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  • 4
    Electronic Resource
    Electronic Resource
    Carotid-ophthalmic aneurysms (1970)
    Springer
    Acta neurochirurgica 22 (1970), S. 289-304 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A series of 16 cases of carotid-ophthalmic aneurysm treated by direct approach is reported and the following points are emphasized: the aneurysm was associated with signs of optic nerve compression in half of the cases. angiography did not always disclose the possibilities and the hazards of direct surgery. indirect surgery (common carotid ligation) did not prevent the aneurysm from growing or restore useful vision. On the other hand, ligation of the aneurysmal neck or local trapping, where necessary, followed by removal of the aneurysm resulted in marked improvement of impaired vision. The hazard of ophthalmic artery occlusion is stressed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01402996
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  • 5
    Electronic Resource
    Electronic Resource
    Normal pressure hydrocepkalus (1972)
    Springer
    Acta neurochirurgica 27 (1972), S. 1-9 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Report on a series of 30 patients with the syndrom of normal pressure hydrocephalus which have been treated by ventriculo-atrial CSF shunt. The diagnostic findings and operative results have been analysed and discussed. Patients with a history of head trauma, subarachnoid bleeding or intracranial surgery seem to have a better prognosis than cases without such aetiological factors or atypical clinical syndrom.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01402167
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  • 6
    Electronic Resource
    Electronic Resource
    Results of surgical management of 319 pituitary adenomas (1987)
    Springer
    Acta neurochirurgica 85 (1987), S. 117-124 
    Details
    ISSN: 0942-0940
    Keywords: Pituitary adenomas ; transsphenoidal and transcranial approach
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Of the 510 patients with pituitary adenoma treated surgically at our hospital in the period 1956–1984 319 were treated by the microsurgical technique, in the period 1973–1984, 235 by transsphenoidal approach and 84 by subfrontal-pterional approach. The transsphenoidal route was used almost exclusively in microadenomas, in intrasellar adenomas, in suprasellar adenomas with midline development, in adenomas invading the sphenoidal sinus and in haemorrhagic adenomas with considerable suprasellar development. In some giant adenomas the transsphenoidal route was used in a first stage operation for debulking the tumour, later removed by transcranial route. The latter route was preferred in large adenomas and especially in adenomas with laterosellar development. In some patients with PRL secreting adenomas post-operative treatment with bromocriptine proved useful when the hormone levels failed to noramlize. Post-operative radiotherapy was of value in invasive adenomas and in cases in which tumour removal was not radical.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01456107
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  • 7
    Electronic Resource
    Electronic Resource
    European courses of neurosurgery and other training and postgraduate education activities of the European association of neurosurgical societies (1987)
    Springer
    Acta neurochirurgica 86 (1987), S. 115-128 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01402295
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  • 8
    Electronic Resource
    Electronic Resource
    Electron-microscopic visualization of binding of antibodies from sera of glioma patients on cultured glioma cells (1983)
    Springer
    Acta neuropathologica 59 (1983), S. 127-132 
    Details
    ISSN: 1432-0533
    Keywords: Humoral immune response ; Glioma antigens ; Ultrastructural localization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Several human cell lines (normal and neoplastic glia, cerebral metastases from adenocarcinoma, fibroblasts) were incubated with sera from patients with well and poorly differentiated glioma and with sera from healthy donors and then stained with PAP complex to define and localize the antibody reaction with cell surface antigens by means of electron microscopy. The sera of glioma patients proved to contain antibodies which bound the tumor-associated antigenic determinants on the cell membranes of gliomas and of cerebral metastases from adenocarcinoma in tissue cultures. Further, absorption testing of the reactive sera on normal brain, well-differentiated astrocytoma and cultured glioblastoma cells, together with cross-reactivity experiments suggests that at least two antigens or groups of antigens are expressed on the glioma cell surface: one shared by well and poorly differentiated glioma cells and the other by poorly differentiated glioma cells and the cells of cerebral metastases from adenocarcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691598
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  • 9
    Electronic Resource
    Electronic Resource
    Follow-up study of 100 cases of pseudotumor cerebri (1968)
    Springer
    Acta neurochirurgica 18 (1968), S. 259-267 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Autoren bringen eine Analyse von 100 Fällen mit idiopathischem Pseudotumor cerebri (ätiologisch ungeklärte intrakranielle Drucksteigerung). Die klinischen und Laborbefunde werden kurz beschrieben. Die Befunde werden mit entsprechenden Befunden des Schrifttums verglichen. Die verschiedenen therapeutischen Möglichkeiten werden zusammengefaßt. 81 Fälle der Serie konnten für einen Zeitraum von 3 Monaten bis zu 10 Jahren nachbeobachtet werden. Bei 80 von ihnen war der Verlauf günstig, unabhängig von der durchgeführten Behandlung. Auf Grund einer Auswertung von 36 Fällen betrug die durchschnittliche Dauer des Syndroms 10 Wochen.
    Abstract: Résumé Les auteurs font l'étude de 100 cas de pseudo-tumeur cérébrales idiopathiques (hypertension intracrânienne cryptogénétique). Le syndrome clinique et les examens de laboratoire complémentaires sont ensuite analysés et comparés à ceux de cas similaires rapportés dans la littérature. Les hypothèses variées sur pathogénie du syndrome et le traitement sont ensuite discutées. Sur les 100 cas, 81 peuvent être suivis pour une période allant de 3 mois à 10 ans et l'évolution fut favorable chez 80 d'entre eux, quelle que fut la thérapeutique appliquée. Après analyse particulière de 36 cas, on a pu déclaré que la durée moyenne du syndrome était de 10 semaines.
    Notes: Summary 100 cases of idiopathic Pseudotumor cerebri (cryptogenetic intracranial hypertension) are analysed. The clinical and laboratory features are briefly described. The data are compared with similar data from the literature and the relevant therapeutic procedures are summarised. Of this series 81 cases were followed up for a period ranging from 3 months to 10 years. The course was favourable for 80 of them, irrespective of the treatment given. The average duration of the syndrome, on the basis of 36 cases, was 10 weeks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01405720
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  • 10
    Electronic Resource
    Electronic Resource
    Ventriculo-atrial shunt in 200 cases of non tumoural hydrocephalus in children: Remarks on the diagnostic criteria, postoperative complications and long-term results (1969)
    Springer
    Acta neurochirurgica 21 (1969), S. 295-308 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird ein Bericht über 200 Fälle kindlichen, nicht tumorbedingten Hydrozephalus gegeben, die durch ventrikulovenösen shunt operiert wurden. Die präoperativen Untersuchungen, die Art des verwendeten Ventilsystems, die beobachteten Komplikationen und die Ergebnisse werden beschrieben. Es wird darauf hingewiesen, daß die rechtsseitige Brachialis-Angiographie in Ergänzung der Luftuntersuchungen des Ventrikelsystems für die Erkennung der Art des Hydrozephalus und für den Ausschluß einer Hydranenzephalie eine nützliche Untersuchungsmethode ist. Das Pudenz-Ventilsystem ohne Reservoir wird bevorzugt wegen einer geringen Häufigkeit von infektiösen Komplikationen. Unter den postoperativen. Komplikationen kam bei drei Fällen eine ungewöhnlich produktive Ependymitis vor, die zur Obliteration der Ventrikel führte. Die Langzeitergebnisse, gemessen an der psychomotorischen Entwicklung, waren bei mehr als 50% der Fälle ausgezeichnet oder gut.
    Abstract: Résumé Revue de 200 cas d'hydrocéphalie non tumorale opérées par dérivation ventriculo-atriale. Les examens préopératoires, le type de la valve employée, les complications observées, et les résultats sont exposés. L'angiographie rétrograde par voie brachiale droite est une technique souvent utilisée complétant les explorations par l'air, dans le diagnostic du type d'hydrocéphalie, et pour éliminer les cas d'hydro-anencéphalie. La valve de Pudenz sans réservoir est préférée à cause de la faible fréquence de complications. Dans les complications post-opératoires, on signale 3 cas d'obstruction ventriculaire par développement inhabituel de tissu épendymaire. Les résultats à long terme, évalués selon le développement psychomoteur sont excellents ou bons dans plus de 50% des cas.
    Notes: Summary 200 cases of infantile non tumoural hydrocephalus operated by ventriculo-venous shunt have been reviewed. The preoperative studies, the type of valve employed, the complications observed, and the results obtained are described. Retrograde right brachial angiography is emphasized as a useful technique, complementing air studies, in diagnosing the type of hydrocephalus and in excluding cases of hydranencephaly. The Pudenz valve without reservoir is preferred because of a low incidence of infective complications. Among the postoperative complications, an unusual productive ependymitis leading to obliteration of ventricles occurred in 3 cases. Long-term results, evaluated according to psychomotor development, show an incidence of excellent or good result in more than 50% of cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01402963
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