ISSN:
1420-9071
Keywords:
Peptides
;
cardiovascular system
;
immunocytochemistry
;
neuropeptide Y
;
calcitonin gene-related peptide
;
tachykinins
;
substance P
;
vasoactive intestinal polypeptide
;
atrial natriuretic peptide
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Ample immunocytochemical evidence is now available demonstrating that several peptides are present in the mammalian cardiovascular system where they are localised to nerve fibres and myocardial cells. The neuropeptides (neuropeptide Y, calcitonin gene-related peptide, tachykinins and vasoctive intestinal polypeptide) are localised to large secretory vesicles in subpopulations of afferent or efferent nerves supplying the heart and vasculature of several mammals, including man. Although they often exert potent pharmacological effects on the tissues in which they occur their physiological significance has still to be established. They may act directly via specific receptors and/or indirectly by influencing the release and action of other cardiovascular transmitters. In marked contrast, atrial natriuretic peptide is produced by cardiac myocytes and considered to act as a circulating hormone.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01945360
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