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  • 1
    Electronic Resource
    Electronic Resource
    Immuno-electron-microscopic localization of complements in amyloid fibrils of senile plaques (1984)
    Springer
    Acta neuropathologica 63 (1984), S. 296-300 
    Details
    ISSN: 1432-0533
    Keywords: Alzheimer's disease ; Senile plaque ; Amyloid ; Complement ; Immuno-electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The presence of components of immunoglobulins (Ishii et al. 1975) and complements (Eikelenboom and Stam 1982) in senile plaques suggests that the immunologic mechanisms are involved in the causation of pathologic processes in the brain of patients with Alzheimer's disease. Senile plaques consists of amyloid degenerated neuritis and glia, and exact localization of complements among these tissue elements will provide an important clue to the pathogenesis of the Alzheimer brain. This report deals with light- and electronmicroscopic localization of complements in amyloid fibrils of senile plaques by immunoperoxidase histochemistry. The presence of C1q, C4, and C3 is confirmed light-microscopically. At the ultrastructural level, anti-complement C1q, C4, and C3 peroxidase reaction products are exclusively localized on the amyloid fibrils, but no other tissue elements, such as normal or degenerated neurites, neurofibrillary tangles, or glia. The results indicate the presence of immune complex in amyloid fibrils of senile plaques, and little association of complements in senile plaques with neurofilament protein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687336
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  • 2
    Electronic Resource
    Electronic Resource
    Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain (1989)
    Springer
    Acta neuropathologica 77 (1989), S. 569-575 
    Details
    ISSN: 1432-0533
    Keywords: Monoclonal antibody ; Microglial cells ; Alzheimer's disease ; Senile plaques ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A monoclonal antibody, termed AD11/8, reactive to microglial cells, was produced by immunization of mice with partially purified amyloid fibrils of senile (neuritic) plaques. With immunoperoxidase staining on human tissues, AD11/8 also recognized macrophages in the red pulp of the spleen, Kupffer cells in the liver, and macrophages in the bone marrow. The results show that AD11/8 recognizes the antigens associated with mononuclear phagocytes lineage. In normal brains a few resting microglial cells were stained in gray matter, and less frequently in white matter. In senile dementia of the Alzheimer type numerous microglial cells were stained intensively and they often formed clusters in gray matter. By double immunostaining with AD11/8 and a polyclonal antibody against synthetic amyloid β-protein, clustered microglial cells were observed in and around senile plaques with amyloid deposits. Some amyloid plaque cores were surrounded by microglial cell processes. These results indicate that microglial cells may play an important role in senile plaque formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687883
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  • 3
    Electronic Resource
    Electronic Resource
    Evidence that neurofibrillary tangles undergo glial modification (1992)
    Springer
    Acta neuropathologica 85 (1992), S. 101-104 
    Details
    ISSN: 1432-0533
    Keywords: Alzheimer-type dementia ; Ghost tangle ; Microglia ; Astrocyte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ghost tangles, neurofibrillary tangles (NFTs) emerging into extracellular space, appear to be subjected to some microglial association in addition to an invasion of astrocytic processes. Our findings lead us to speculate that the NFTs undergo structural and immunocytochemical modification. Electron microscopic observation of the NFTs in the vascular region indicated either the discharge of NFTs into the vessel or formation of NFTs in the astrocytic end-foot.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304639
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  • 4
    Electronic Resource
    Electronic Resource
    Monoclonal antibodies against CA125-bearing antigenic molecule fragments; reactivity with mucinous ovarian tumours and lung cancers
    Amsterdam : Elsevier
    Molecular and Cellular Probes 5 (1991), S. 55-63 
    Details
    ISSN: 0890-8508
    Keywords: CA125 associated antigen ; lung cancer ; monoclonal antibody (SH9) ; ovarian tumour
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0890-8508(91)90038-L
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  • 5
    Electronic Resource
    Electronic Resource
    Intermittent hypobaric hypoxia increases the ability of neutrophils to generate superoxide anion in humans (2003)
    Oxford, UK : Blackwell Science Pty
    Clinical and experimental pharmacology and physiology 30 (2003), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. We investigated the effect of intermittent exposure to hypobaric hypoxia on the ability of neutrophils to generate ·O2–.2. Seven male volunteers were exposed intermittently to hypobaric hypoxia, equivalent to an altitude of 4500 m, for 7 successive days. Peripheral blood samples were collected before and after the 2 h course of hypobaric hypoxia on days 1 and 7 and neutrophils were subjected to a chemiluminescence assay for ·O2– production.3. On day 1, 2 h exposure to hypobaric hypoxia induced granulocytosis (P 〈 0.01), but the ability of neutrophils to generate ·O2– was unchanged.4. On day 7, such granulocytosis was not observed, suggesting acclimatization to hypobaric hypoxia.5. The ability of neutrophils to generate ·O2– was significantly increased on day 7 (P 〈 0.01), although there was no definite change in the mRNA expression of NADPH oxidase subunits in the cells.6. The results suggest that the ability of neutrophils to generate ·O2– may be gradually potentiated by intermittent exposure to hypobaric hypoxia, even after the number of neutrophils in peripheral blood stabilizes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1440-1681.2003.03891.x
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  • 6
    Electronic Resource
    Electronic Resource
    Homology Between the MPB70 and MPB83 Proteins of Mycobacterium bovis BCG (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 42 (1995), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Isolation of MPB83 from Mycobacterium bovis BCG Tokyo culture fluid is described. MPB70 and MPB83 have similar molecular mass as judged by SDS-PAGE but differ in isoelectric points. Peptides isolated after CNBr cleavage of MPB83 revealed extensive homology as well as distinct differences from corresponding parts of the amino acid sequence deduced from the mpb70 gene cloned by Terasaka et al. Antibodies produced by immunization with MPB70 and MPB83 had distinctly different fine specificity revealing cross-reactivity between the proteins. These findings indicate that two distinct, homologous genes code for these proteins. Sensitization with live BCG Tokyo also induced T cell responses to MPB83 with development of delayed type hypersensitivity in guinea pigs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1995.tb03624.x
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  • 7
    Electronic Resource
    Electronic Resource
    Secretion of MPB64 Antigen by a Recominant Clone of Mycobacterium Smegmatis: Characterization and Application for the Diagnosis of Tuberculosis (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 42 (1995), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: MPB64, a specific antigen to Mycobaeterium tuberculosis complex (TB complex), was produced and secreted by a clone of M. smegmatis-MPB64 where the structural gene of MPB64 was inserted using a new mycobacteria, E. coli shuttle plasmid pNIS vector. Antibodies against the recombinant MPB64 (rMPB64) were used for the reverse particle latex agglutination (RPLA) test to detect the MPB64 antigen rapidly. RPLA tests were applied to the stock cultures and the clinical isolates of mycobacteria to identify TB complex. RPLA with anti-MPB64 antibody-coated latex beads completely distinguished TB complex from other mycobacteria. Thus, it is suggested that RPLA with anti-MPB64 antibody would be a new, easy and inexpensive method for the rapid diagnosis of tuberculosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1995.tb03684.x
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  • 8
    Electronic Resource
    Electronic Resource
    An immunohistochemical study of β-protein in Alzheimer-type dementia brains (1989)
    Springer
    Journal of neurology 236 (1989), S. 214-217 
    Details
    ISSN: 1432-1459
    Keywords: Alzheimer-type dementia ; Senile plaque ; Amyloid deposit ; β-Protein ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An immunohistochemical study with a polyclonal anti-β-protein antiserum was performed in order to understand the mechanism of deposition of amyloid fibrils in senile plaques in Alzheimer-type dementia (ATD). Serial cortical sections cut from ATD brains were necessary to investigate the structural correlation between senile plaques and blood vessels. The senile plaques were stained well and a blood vessel or capillary-like structure was found in most of β-protein-immunoreactive deposits. These findings may suggest an involvement of blood vessels in the formation of at least some of the amyloid deposits in ATD brains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314502
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  • 9
    Electronic Resource
    Electronic Resource
    Stroke due to a fusiform aneurysm of the cervical vertebral artery: case report (1998)
    Springer
    Neuroradiology 40 (1998), S. 19-22 
    Details
    ISSN: 1432-1920
    Keywords: Key words Vertebral artery cervical ; aneurysm fusiform ; infarct pontine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aneurysms of the cervical vertebral artery (VA) are uncommon; they are often caused by trauma or spontaneous dissection. A fusiform aneurysm without evidence of atherosclerosis or dissection has not been reported previously. A 46-year-old man presented with a pontine infarct. Imaging revealed a fusiform aneurysm of the left VA at the C5–6 level, with occlusion of the basilar artery. Associated minor anomalies included fusion of the vertebral bodies of C5 and C6, cervical rib and platybasia. The left VA arose directly from the aortic arch and entered the transverse foramen at the C4 level. Hyperextension and left lateral flexion of the neck caused kinking of the VA proximal to the aneurysm. Turbulent flow in the aneurysm lumen was noted on angiography.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050531
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