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  • 1
    Electronic Resource
    Electronic Resource
    Organometallic phosphazenes: synthesis and rearrangement of propynyl- and propadienylcyclotriphosphazenes (1981)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 103 (1981), S. 2256-2261 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00399a020
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  • 2
    Electronic Resource
    Electronic Resource
    Polymerization of Monoalkylpentachlorocyclotriphosphazenes (1979)
    s.l. : American Chemical Society
    Macromolecules 12 (1979), S. 1014-1015 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma60071a049
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  • 3
    Electronic Resource
    Electronic Resource
    Imaging of renal medullary interstitial cells in situ by confocal fluorescence microscopy (1999)
    Springer
    Anatomy and embryology 200 (1999), S. 117-121 
    Details
    ISSN: 1432-0568
    Keywords: Key words Rat ; Papilla ; Kidney ; Lipid ; Fluorescent dyes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Renal medullary interstitial cells are a prevalent and characteristic feature of the inner medulla of the kidney, but the physiological significance of this is unclear. We have developed a method for imaging renal medullary interstitial cells in situ by loading the cells with fluorescent dyes and monitoring their distribution using confocal microscopy. The pH-sensitive probe 2’7’-bis-(carboxyethyl)-5-(and-6)-carboxyfluorescein acetoxymethyl ester was used as a marker of cytoplasmic volume and therefore of cell morphology. Nile Red was used to demonstrate the presence of renal medullary interstitial cell lipid droplets. Papillae were excised from 100 g Sprague-Dawley rats and loaded with the appropriate dye. The papillae were then examined using a Leica TCS 4D confocal microscope and oil immersion lenses. Fluorescence was excited (488 nm) using an argon laser and emission wavelengths above 515 nm collected using a long pass filter. Images of papillae loaded with 2’7’-bis-(carboxyethyl)-5-(and-6)-carboxyfluorescein acetoxymethyl ester clearly demonstrate a ladder-like arrangement of renal medullary interstitial cells. More detailed examination revealed the presence of cytoplasmic extensions that appear to make close contact with adjacent loops of Henle. Three-dimensional reconstructions of serial sections revealed spiral arrangements in some ladders of renal medullary interstitial cells. Nile Red-labelled lipid droplets of 0.5–1.0 µm diameter were located throughout the cytoplasm of renal medullary interstitial cells and especially within the cytoplasmic extensions. These experiments highlight the ability of confocal microscopy to allow investigation of renal medullary interstitial cells in situ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004290050265
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  • 4
    Electronic Resource
    Electronic Resource
    Water quality impacts from on-site waste disposal systems to coastal areas through groundwater discharge (1995)
    Springer
    Environmental geology 26 (1995), S. 262-268 
    Details
    ISSN: 1432-0495
    Keywords: Contaminated groundwater ; On-site disposal systems ; Nutrient enrichment ; Nonpoint source pollution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract This report summarizes research studies linking on-site waste disposal systems (OSDS) to pathogen and nutrient concentrations in groundwater with the potential to impact coastal embayments. Few studies connect OSDS to coastal water quality. Most studies examined pathogen and nutrient impacts to groundwater and omitted estimations of contaminants discharged to surface water. The majority of studies focused on nitrogen, with little information on pathogens and even less on phosphorus. Nitrogen discharged from OSDS poses the greatest threat to water quality. Vertical distance of septic tank infiltration system from the water table, septic system design, and siting remain the key components in minimizing potential impacts from OSDS for control of both pathogens and nutrients. The most comprehensive information connecting nutrient contributions from OSDS to surface water quality was the study conducted on Buttermilk Bay in Massachusetts where 74% of nitrogen to the bay was attributed to onsite disposal systems. In conclusion, further studies on the viability and transport of pathogens and nutrients through the groundwater aquifer and across the groundwater/surface-water interface are needed. Additional research on the importance of septic system design on the availability of contaminants to groundwater as well as the minimum distance between the septic system and water table necessary to protect groundwater are also indicated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00770477
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  • 5
    Electronic Resource
    Electronic Resource
    EFFECTS OF RENAL DENERVATION AND ATRIAL NATRIURETIC FACTOR ON TUBULAR REABSORPTION IN ANAESTHETIZED RATS (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 16 (1989), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effects of acute unilateral renal denervation were examined in 17 anaesthetized rats. Renal haemodynamic changes were monitored using standard clearance techniques. Lithium clearance was used to assess fractional proximal sodium and water reabsorption.2. Denervation resulted in ipsilateral renal vasodilatation with marked natriuresis and diuresis, a small increase (15%, P 〈 0.05) in glomerular filtration rate (GFR) and a consequent reduction in filtration fraction. Fractional lithium reabsorption decreased (67.3 ± 2.9% to 54.5 ± 4.0%, P 〈 0.01) and absolute proximal reabsorption did not change, indicating impairment of proximal glomerulotubular balance (GTB). No similar changes in haemodynamic or transport parameters were observed in the contralateral, innervated kidney, although vascular resistance increased.3. In 9 experiments following denervation of the left kidney, systemic low dose infusion (10 ng/min) of atrial natriuretic factor (ANF) resulted in a fall in mean arterial blood pressure from 116 ± 3 mmHg to 107 + 3 mmHg (P 〈 0.05). In the denervated kidney ANF increased urine flow rate and sodium excretion to rates above those established following denervation alone. However, in the right kidney, despite the increased filtered load (35%, P 〈 0.01), the natriuretic and diuretic responses to ANF were abolished.4. In the denervated kidney, ANF further reduced the fractional reabsorption of lithium from 53.6 ± 2.3% to 45.6 ± 3.8% (P 〈 0.05). GFR increased by 32% (a total of 49% higher than during pretreatment) but absolute proximal reabsorption (APR) did not change. However, in the right, innervated kidney ANF infusion produced a 35% increase in GFR accompanied by a 53% rise in APR.5. It is concluded that the natriuresis induced by unilateral denervation is due predominantly to impaired proximal GTB. The natriuretic action of ANF was associated with further impairment of proximal GTB, not dependent upon decreasing activity of renal sympathetic nerves, but was abolished when filtration fraction and renal sympathetic tone were elevated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1989.tb01515.x
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  • 6
    Electronic Resource
    Electronic Resource
    SAR1-LEU8-ANGIOTENSIN II REVERSES THE EFFECTS OF CAPTOPRIL ON RENAL FUNCTION IN RATS (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 13 (1986), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. In Inactin-anaesthetized rats inhibition of angiotensin converting enzyme by captopril resulted in a small decrease in mean arterial blood pressure accompanied by increases in the rates of glomerular filtration, water and electrolyte excretion.2. Infusion (100 pmol/min) of sar1-leu8-angiotensin II (sar1-leu8-AII) during continuing converting enzyme blockade reversed these changes in renal function but had no effect on arterial blood pressure.3. The data indicate that sar1-leu8-AII has partial agonist activity in the kidney although it acts as an antagonist of AII in the systemic circulation. This supports the proposai that angiotensin receptors within the kidney differ from those in the peripheral circulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1986.tb00318.x
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  • 7
    Electronic Resource
    Electronic Resource
    MODULATION OF PROXIMAL TUBULAR REABSORPTION BY ANGIOTENSIN II (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 13 (1986), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. In shrinking-drop micropuncture studies in anaesthetized rats proximal tubular fluid reabsorption (Jva) decreased by 36% following intravenous infusion of enalapril. In a separate group of rats enalapril reduced fractional lithium clearance indicating decreased proximal fluid reabsorption.2. Following enalapril, GFR rose by 46% but absolute proximal reabsorption rose by 22% indicating 48% effectiveness of proximal glomerulo-tubular balance (GTB). Since renal blood flow and glomerular filtration rate (GFR) increased in parallel and arterial pressure fell, fluid uptake and proximal GTB were unlikely to have been decreased by peritubular physical forces.3. In anaesthetized rats proximal fluid reabsorption and proximal GTB are modulated by endogenous All through direct stimulation of proximal tubular transport.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1986.tb00348.x
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  • 8
    Electronic Resource
    Electronic Resource
    BOOK REVIEW (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 13 (1986), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1986.tb02417.x
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  • 9
    Electronic Resource
    Electronic Resource
    ALTERED BLOOD PRESSURE, RENAL TUBULAR FUNCTION AND LEVELS OF CIRCULATING INHIBITORS OF Na-K-ATPase IN MATURE SHR EXPOSED TO LOW SALT DIET IN THE PERINATAL PERIOD (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 20 (1993), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. It has been shown previously that low salt diet, confined to the perinatal period only, reduces blood pressure (BP) and sodium retention in spontaneously hypertensive rat (SHR) offspring at maturity when compared with those given high salt diet.2. In this study it is shown that such high salt diets are associated with an increased level of circulating Na-K-ATPase inhibitor (CINK) activity.3. Animals given perinatal high salt diet have a significantly greater tubular reabsorptive capacity when compared with those given low salt diet.4. The finding of a high level of circulating Na-K-ATPase inhibitory material in the face of increased renal tubular capacity and blood pressure suggests that while this inhibitory material may play a role in the elevated blood pressure of animals given high salt diet, it cannot cause the elevated rate of fluid reabsorption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1993.tb01701.x
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  • 10
    Electronic Resource
    Electronic Resource
    Temperature sensitivity of bromosulphophthalein clearance by the liver (1975)
    Springer
    Cellular and molecular life sciences 31 (1975), S. 447-449 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé L'épuration de la bromosulphophtaléine (BSP) par le foie de rat perfusé a été étudiée à 37°C et à 27°C. Les courbes de disparition de la BSP indiquent un changement dans le mécanisme d'épuration à la température inférieure. L'épuration de la BSP est utilisée comme mesure de la vitesse d'écoulement aux 2 températures; moyennant une correction appropriéc un bon accord est obtenu avec les mesures directes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02026371
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