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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and pharmacodynamics of alprenolol in the treatment of hypertension (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 89-95 
    Details
    ISSN: 1432-1041
    Keywords: Adrenergic beta receptor blockade ; drug plasma concentrations ; plasma renin activity ; essential hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The kinetics of alprenolol, in relation to its effect on blood pressure and plasma renin activity, have been studied in sixteen patients. A within-patient comparison was made between therapy for six weeks with placebo or alprenolol 200 mg thrice daily. Thirteen patients responded to alprenolol by a significant fall in blood pressure. In three other patients treatment did not lower blood pressure. In the group as a whole there was no significant correlation between the fall in systolic, diastolic or mean blood pressure, and the steady-state plasma alprenolol concentration, renin status, or degree of beta blockade. However, the thirteen responsive patients showed a significant relationship (p〈0.05 – 0.001) between the log mean steady-state plasma alprenolol concentration and the hypotensive response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609465
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Monoamine metabolites in cerebrospinal fluid during treatment with clonidine or alprenolol (1977)
    Springer
    European journal of clinical pharmacology 11 (1977), S. 125-128 
    Details
    ISSN: 1432-1041
    Keywords: Clonidine ; alprenolol ; amine metabolites ; cerebrospinal fluid ; hypertension ; noradrenaline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Lumbar cerebrospinal fluid (CSF) concentrations of the major metabolites of noradrenaline (4-hydroxy-3-methoxyphenyl glycol, HMPG), serotonin (5-hydroxyindoleacetic acid) and dopamine (homovanillic acid) were measured before and during the administration of clonidine or alprenolol to hypertensive patients. The noradrenaline receptor stimulant clonidine significantly decreased the CSF level of HMPG, but there was no consistent change in the concentration of serotonin or dopamine metabolites. Patients on alprenolol showed no change in the levels of these metabolites in CSF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00562903
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Cadralazine pharmacokinetics — A pilot study (1988)
    Springer
    European journal of clinical pharmacology 35 (1988), S. 571-572 
    Details
    ISSN: 1432-1041
    Keywords: cadralazine ; pharmacokinetics ; hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558256
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Time course of blood pressure, pulse rate, plasma renin and metoprolol during treatment of hypertensive patients (1980)
    Springer
    European journal of clinical pharmacology 17 (1980), S. 321-328 
    Details
    ISSN: 1432-1041
    Keywords: metoprolol ; hypertension ; pharmacokinetics ; plasma renin ; blood pressure effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Eleven patients were treated for essential hypertension with metoprolol (Selokén®) for more than three months. The time course of changes in blood pressure, pulse rate and plasma renin activity was studied during treatment with an oral maintenance dose of 100 mg twice daily. Significant decreases in pulse rate, diastolic blood pressure and plasma renin activity were observed even after the first dose. The plasma concentration of metoprolol reached equilibrium after the second dose. After the third dose there was no further significant change in blood pressure. There was a significant correlation (p〈0.001) between the initial (after three doses) and final (after 〉90days) effect of metoprolol on blood pressure (r=0.86 and 0.91 for systolic and diastolic blood pressure change, respectively).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558443
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and pharmacodynamics of alprenolol in the treatment of hypertension (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 85-88 
    Details
    ISSN: 1432-1041
    Keywords: Adrenergic beta receptor blockade ; drug plasma concentrations ; plasma renin activity ; essential hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Mean steady-state plasma concentrations of alprenolol were studied in relationship to the degree of beta-blockade, in sixteen patients receiving 600 mg daily in divided doses. Steady-state alprenolol concentrations were determined from the area under the plasma concentration-time curve during one eight-hour dosage interval after treatment for six weeks. Beta-blockade during alprenolol treatment was assessed from the chronotropic response to intravenous isoprenaline compared to the response after six weeks of placebo therapy. Although there was interindividual variability in the mean steady-state alprenolol concentration (range 11 — 141 ng/ml), and in the degree of beta-blockade (7-fold), the correlation between the two variables was highly significant (r=0.80, p〈0.001). The prescribed dose of alprenolol (mg/kg) was not significantly correlated with the plasma level of alprenolol or the β-blockade. The chronotropic effects of isoprenaline during placebo and alprenolol were significantly interrelated (r=0.79, p〈0.001).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609464
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  • 6
    Electronic Resource
    Electronic Resource
    Monoamine metabolites in cerebrospinal fluid during treatment of hypertension with prazosin (1980)
    Springer
    European journal of clinical pharmacology 18 (1980), S. 399-401 
    Details
    ISSN: 1432-1041
    Keywords: prazosin ; hypertension ; central monoaminergic neurons ; monoamine metabolites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Six hypertensive patients were treated with prazosin up to a final dose of 3–4.5 mg/day. There was a significant reduction of blood pressure. The cerebrospinal fluid (CSF) concentrations of the major metabolites of noradrenaline, dopamine and serotonin were unchanged. This indicates that the antihypertensive effect is not mediated via central monoaminergic neurons as suggested by animal studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00636792
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Spray cultivation of seaweeds in recirculating brackish water
    Amsterdam : Elsevier
    Aquaculture 72 (1988), S. 181-189 
    Details
    ISSN: 0044-8486
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0044-8486(88)90158-5
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Photosynthesis and respiration in the alga Ahnfeltia plicata in a flow-through system (1987)
    Springer
    Marine biology 96 (1987), S. 409-412 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Photosynthesis and respiration in Ahnfeltia plicata (Huds.) Fries (Gigartinales) was measured in a seawater flowthrough system at different temperatures, salinities and photon flux densities (PFD). The exchanges of dissolved oxygen and inorganic carbon were continuously recorded with an oxygen probe and a pH electrode measuring variation in CO2−HCO 3 - equilibrium as pH changes. Highest apparent photosynthesis at moderate photon flux density (PFD 50 μE m-2 s-1) was found at 15°C and 33‰ S. Photosynthesis was measured up to PFD 500 μE m-2 s-1 and no light saturation was documented. In the present experimental set-up, with continuous supply of fresh seawater, the number of limiting factors during photosynthesis measurements is reduced.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00412525
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    Paper (German National Licenses)
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