ISSN:
1432-1041
Keywords:
Adrenergic beta receptor blockade
;
drug plasma concentrations
;
plasma renin activity
;
essential hypertension
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The kinetics of alprenolol, in relation to its effect on blood pressure and plasma renin activity, have been studied in sixteen patients. A within-patient comparison was made between therapy for six weeks with placebo or alprenolol 200 mg thrice daily. Thirteen patients responded to alprenolol by a significant fall in blood pressure. In three other patients treatment did not lower blood pressure. In the group as a whole there was no significant correlation between the fall in systolic, diastolic or mean blood pressure, and the steady-state plasma alprenolol concentration, renin status, or degree of beta blockade. However, the thirteen responsive patients showed a significant relationship (p〈0.05 – 0.001) between the log mean steady-state plasma alprenolol concentration and the hypotensive response.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00609465
