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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Analytica Chimica Acta 158 (1984), S. 297-303 
    ISSN: 0003-2670
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of environmental contamination and toxicology 34 (1998), S. 297-305 
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract. The water from some drilled wells in southwest Finland contains high arsenic concentrations (min–max: 17–980 μg/L). We analyzed inorganic arsenic (As-i) and organic arsenic (monomethylarsonate [MMA] and dimethylarsinate [DMA]) species in urine and conducted a clinical examination of current users (n = 35) and ex-users (n = 12) of such wells. Ex-users had ceased to use the water from the wells 2–4 months previously. Urinary arsenic species were also analyzed from persons whose drinking water contained less than 1 μg/L of arsenic (controls, n = 9). The geometric means of the concentrations of total arsenic in urine were 58 μg/L for current users, 17 μg/L for ex-users, and 5 μg/L for controls. The excreted arsenic was associated with the calculated arsenic doses, and on average 63% of the ingested arsenic dose was excreted in urine. The ratios of MMA/DMA and As-i/As-tot (As-tot = As-i + MMA + DMA) in urine tended to be lower among the current users and in the higher exposure levels than in controls, suggesting that As-i was better methylated in current users. However, the differences were mainly explained by age; older persons were better methylators of inorganic arsenic than younger individuals. The arsenic content of hair correlated well with the past and chronic arsenic exposure; an increase of 10 μg/L in the arsenic concentration of the drinking water or an increase of 10–20 μg/day of the arsenic exposure corresponded to a 0.1 mg/kg increase in hair arsenic. The individuals were interviewed and complained of muscle cramps, mainly in the legs, and this was associated with elevated arsenic exposure. The present study demonstrates that arsenic methylation has no threshold at these exposure levels.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-2013
    Keywords: Oxygen uptake ; Blood lactate ; Blood acid base balance ; Endurance running ; Serum myoglobin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of 30 min running with stepwise increasing intensity (exhaustive, energy demand approx. 50 → 100% ofVO2max), 60 s supramaximal running (anaerobic, ≥125% ofVO2max) and 40–60 min low-intensity running (acrobic, 40–60% ofVO2max) on serum concentration of muscle-derived proteins were studied in 5 male and 5 female elite orienteerers. S-Carbonic anhydrase III (S-CA III) was used as a marker of protein leakage from type I (slow oxidative) muscle fibres and S-myoglobin (S-Mb) as a non-selective (type I+II) muscular marker. The fractional increase in S-CA III (ΔS-Ca III) was 0.37±0.09 (mean±SEM,p〈0.001), 0.10±0.05 (N. S.) and 0.46±0.09 (p〈0.001) 1 h after exhaustive, anaerobic and aerobic exercise, respectively. The corresponding values for ΔS-Mb were 1.45±0.36 (p〈0.001), 0.39±0.13 (p〈0.01) and 0.67±0.18 (p〈0.001). The value for the ΔS-CA III/ΔS-Mb ratio was 0.68±0.03 after the acrobic exercise, but only 0.25–0.26 (p vs. aerobic exercise 〈0.001) after the two high-intensity forms of exercise. Since type I fibres of skeletal muscle are known to be responsible for power production during low-intensity exercise, whereas fibres of both type I and type II are active at higher intensities, the ΔS-CA III/ΔS-Mb ratio may depend on the recruitment profile of type I vs. type I+II fibres.
    Type of Medium: Electronic Resource
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