Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    A direct involvement of the central nervous system in hypophagia and inhibition of respiratory rate in rats after treatment with O,O,S-trimethyl phosphorothioate (1995)
    Springer
    Archives of toxicology 69 (1995), S. 559-564 
    Details
    ISSN: 1432-0738
    Keywords: Key words OOS-TMP ; Intracerebroventricular injection ; Inhibition of respiratory rate ; Fischer 344 rats ; Toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract   O,O,S-Trimethyl phosphorothioate (OOS-TMP) is known to induce unique symptoms, which are characterized by hypophagia, progressive weight loss, and hypothermia. To determine whether there is the possibility of a causal relationship between these toxic symptoms and a direct action of OOS-TMP on the central nervous system, we investigated the development of these symptoms in Fischer 344 female rats after oral or intracerebral treatment with OOS-TMP. Oral administration of OOS-TMP at 20 mg/kg induced marked hypophagia, progressive weight loss and hypothermia. Moreover, inhibition of respiratory rate was observed immediately after treatment. It lasts during the entire experimental period. Profound hypothermia below 34°C was observed more frequently in the rats, which became hypercapnic (PaCO2≥ 50 mmHg). In contrast, administration of OOS-TMP at 20 mg/kg (as much as the oral dose) into the cerebral lateral ventricle succeeded in inducing hypophagia, progressive weight loss and lowered respiratory rates. On the other hand, by this route of administration, OOS-TMP at 20 mg/kg failed to induce hypothermia, hypercapnia and lung injury. The present results suggest that hypophagia and inhibitions of respiratory rate are attributable to the direct action of OOS-TMP on the central nervous system, while other symptoms are associated with lung injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002040050212
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    O,O,S-Trimethyl phosphorothioate induces hypothermia in Fischer 344 rats in a manner dependent on both doses and housing temperatures (1993)
    Springer
    Archives of toxicology 67 (1993), S. 72-75 
    Details
    ISSN: 1432-0738
    Keywords: OOS-TMP ; Hypothermia ; Fischer 344 rats ; Housing temperature ; Toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We explored the effects of O,O,S-trimethyl phosphorothioate (OOS-TMP) on body temperatures in Fischer 344 female rats. The 7-day LD50 p.o. for Fischer 344 female rats was found to be 11.8 mg/kg. OOS-TMP induced long-lasting (more than 48 h) and extensive hypothermia at doses 〉 14 mg/kg at a typical laboratory temperature (22° C) while it produced typical symptoms at 10 mg/kg without hypothermia. In contrast, pair-fed (to 20 mg/kg rats) rats (n=4) did not become hypothermic, negating any role of hypophagia in OOS-TMP associated hypothermia. We next investigated the effects of housing temperatures on toxicities at a LD50 dose (12 mg/kg). At 30° C (n=11) and 22° C (n=13), rats did not have hypothermic bouts but at 15° C, eight out of ten rats had. Evidence that changes of housing temperatures neither modified clinical symptoms nor changed mortality rates discards a possibility of hypothermia being involved in delayed toxicity. A novel result of the present study suggests that thermoregulation may be heavily impaired by a special class of organophosphorus compounds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02072039
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Electrophoresis of phosphoglycerate kinase-2 to determine testicular damage induced by ethylene glycol monomethyl ether and sterility associated with chromosomal abnormality (1990)
    Springer
    Archives of toxicology 64 (1990), S. 181-187 
    Details
    ISSN: 1432-0738
    Keywords: Testicular toxicity ; Ethylene glycol monomethyl ether ; PGK-2 ; Sterility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Phosphoglycerate kinase (PGK, EC 2.7.2.3), which is expressed specifically in sperm and spermatids, is an enzyme in the Embden-Meyerhof pathway that converts glucose to pyruvate. We developed an electrophoresis method to determine relative PGK-2 quantity and applied it to evaluate spermatogenesis activity. In the ethylene glycol monomethyl ether (EGME)-induced testicular toxicity, relative PGK-2 quantity had not decreased until 4 weeks of exposure. Mean relative PGK-2 quantities, defined as PGK-2 quantity over PGK-1 quantity in a pooled spleen sample (±SD) were: 1.43±0.32 for control animals (N=10); 1.67±0.24 for the group exposed at 500 mg/kg for 5 days (N=6); 1.85±0.58 for the group exposed at 500 mg/kg for 2 weeks (N=6); 0.09±0.06 for the group exposed at 500 mg/kg for 4 weeks (N=6); not detectable in animals exposed at 500 mg/kg for 5 weeks (N=7); 0.208±0.103 for the group exposed at 250 mg/kg for 5 weeks (N=6); and 1.35±0.38 for the group exposed at 125 mg/kg for 5 weeks (N=6). These relative quantities showed a good correlation with sperm/spermatid counts (r=0.823,p〈0.01) and histological findings. These findings suggest that EGME has toxicity on primary spermatocytes and spermatogonia. In the case of sterility associated with a chromosomal abnormality (chromosomal translocation between chromosome X and 16), relative PGK-2 quantity was not detected in any of the seven adult (12 weeks of age) mice, although many primary spermatocytes were detected by histological examination. Those findings suggest that cellular differentiation is arrested at meiosis due to the chromosomal abnormality. It was thus concluded that relative PGK-2 quantity provides information on testicular development and is therefore useful as an indicator of testicular function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02010723
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...