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  • 1
    Electronic Resource
    Electronic Resource
    Anti-k (Anti-Cellano) im Serum einer mehrfach transfundierten Patientin (1957)
    Springer
    Annals of hematology 3 (1957), S. 149-150 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Es wird ein Fall von Anti-k bei einer 18jährigen Nullipara beschrieben, die 4 Transfusionen erhalten hatte. Auf die Bedeutung der Antikörper mit hohem Prozentsatz positiver Reaktionen bei sogenannten «nicht Kreuztest-fähigen» Patienten-Blutproben mit negativem direkten Coombstest wird hingewiesen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01630690
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  • 2
    Electronic Resource
    Electronic Resource
    Renaler Magnesiumtransport bei Glomerulonephritis und Pyelonephritis unter besonderer Berücksichtigung des Terminalstadiums (1971)
    Springer
    Journal of molecular medicine 49 (1971), S. 251-255 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Unter Standard-Clearance-Bedingungen weisen Patienten mit Glomerulonephritis gehäuft eine erhöhte Magnesium-Ausscheidung auf. Diese erfährt bei komplizierendem Hochdruck eine weitere Steigerung. Pyelonephritispatienten zeigen vornehmlich bei hypertoner Verlaufsform eine Hypermagnesiurie, die nicht mit entsprechendem Anstieg der Natriumexkretion verbunden ist. Im Stadium der terminalen Niereninsuffizienz (GFR 〈 20 ml/min) ist die CMg bei Pyelonephritis signifikant, bei Glomerulonephritis hingegen nur insignifikant reduziert. Die fraktionelle Magnesiumexkretion ist bei Niereninsuffizienz beträchtlich gesteigert. Bei Patienten mit Glomerulonephritis besteht in Einzelfällen eine Nettosekretion. Als Ursache der prävalenten Magnesiumausscheidung bei Glomerulonephritis müssen neben einem sekundären Hyperaldosteronismus weitere krankheitsspezifische Faktoren diskutiert werden.
    Notes: Summary Clearance studies in patients withglomerulonephritis revealed a significant increase of magnesium excretion with highest values in the presence of hypertension. In patients with hypertensive pyelonephritis, magnesium clearance was elevated too, whereas only a tendency to increasing levels was observed in cases with normal blood pressure. Inthe end phase of renal failure with GFR reduction to less than 20 ml/min, magnesium clearance was significantly reduced in pyelonephritis, but to a smaller extent in glomerulonephritis. In the latter group, some patients showed a net secretion of magnesium. Besides the presence of a secondary hyperaldosteronism, additional factors specific for this disease, have to be considered as the cause of the high magnesium excretion rate in glomerulonephritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01485425
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  • 3
    Electronic Resource
    Electronic Resource
    Chronischer, nicht-sphärocytärer hämolytischer Ikterus bei völligem Fehlen der Glucose-6-Phosphatdehydrogenaseaktivität der Erythrocyten (1964)
    Springer
    Journal of molecular medicine 42 (1964), S. 1250-1250 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01496761
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  • 4
    Electronic Resource
    Electronic Resource
    Die Behandlung der chronischen Niereninsuffizienz mit einer neuartigen Modifikation der intestinalen Dialyse (1970)
    Springer
    Journal of molecular medicine 48 (1970), S. 819-821 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The experimental basis and first clinical experiences with a new method of „intestinal dialysis“ for treatment of chronic renal failure are demonstrated. The principle of the method is the use of sodium cyclohexansulphamate (cyclamate) as the essential part of the solution for dialysis. Because of the big and non penetrating anion neither sodium nor water are absorbed. There is no loss of any important blood electrolyte. Only urea is eliminated because of the steep concentration gradient between blood and intestinal lumen. The method of „intestinal dialysis“ may be helpful in discharging dialysis centers, and qualified to be practised in small hospitals.
    Notes: Zusammenfassung Tierexperimentelle Grundlagen und erste klinische Erfahrungen mit einer neuen Methode der „intestinalen Dialyse“ zur Behandlung der chronischen Niereninsuffizienz werden mitgeteilt. Das Prinzip des Verfahrens beruht auf der Verwendung von Natrium-Cyclohexansulfamat (Na-Cyclamat) als Hauptbestandteil der Dialysierlösung. Infolge des großen und nicht penetrierenden Anions können weder Na+ noch Wasser absorbiert werden, andererseits kommt es nicht zum Verlust wichtiger Elektrolyte des Plasmas. Die Elimination betrifft vor allem den Harnstoff, für den ein steiler Konzentrationsgradient Blut-Darmlumen besteht. Das Verfahren erscheint zur Entlastung der Dialyse-Zentren und für den Einsatz an kleinen Krankenhäusern geeignet.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01494499
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  • 5
    Electronic Resource
    Electronic Resource
    Katecholamingehalt adrenerger Nerven in Speicheldrüsen mit gestörter Elektrolytausscheidung bei Urämie (1973)
    Springer
    Journal of molecular medicine 51 (1973), S. 1115-1123 
    Details
    ISSN: 1432-1440
    Keywords: Parotid gland ; uremia ; catecholamine content ; adrenergic nerve terminals ; salivary electrolyte ; excretion ; Ohrspeicheldrüse ; Urämie ; Katecholamingehalt ; adrenerge Terminalfasern ; Elektrolytexkretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei Urämie werden charakteristische Veränderungen der Exkretion von Speichelelektrolyten beobachtet. Diese Veränderungen können teilweise durch Sympathomimetica reproduziert werden. Es lag daher nahe, bei Urämie nach Veränderungen in der adrenergen Innervation der Speicheldrüsen oder indirekten morphologischen Hinweisen für einen „erhöhten Sympathicotonus“ zu suchen. Mit der Methode der Formaldehyd-induzierten Fluorescenz zum histochemischen Katecholaminnachweis und dem histochemischen Enzymnachweis für AChE und G6PD wurden Biopsiematerial von menschlichen Ohrspeicheldrüsen urämischer Patienten mit bekannter Speichelelektrolytexkretion und Gll. submaxill. von Albinoratten mit experimenteller Urämie untersucht. Bei Patienten mit chronischer Urämie wurde im Parotisparenchym stets eine Verringerung der Anzahl der durch Formaldehyd-induzierte Katecholaminfluorescenz nachweisbaren adrenergen Nerven beobachtet. Bei experimenteller Urämie der Ratten blieb das Innervationsmuster unverändert, während die Katecholaminfluorescenz deutlich herabgesetzt war und damit ebenfalls eine Entspeicherung der adrenergen Terminalfasern anzeigte. Quantitative Katecholaminbestimmungen in Herz, Niere und Gl. submaxillaris der Ratten mit experimenteller Urämie bestätigen diesen Pefund. Gesamtkörpernatrium und Speicherungskapazität adrenerger Terminalfasern für Katecholamine scheinen eng miteinander verknüpft zu sein, wie dies für den DOCA-Hochdruck der Ratten bereits bekannt ist.
    Notes: Summary In uremia characteristic changes of salivary electrolyte excretion were observed. These changes can partially be reproduced by sympathomimetic agents. The study was performed to find out changes in adrenergic innervation of salivary glands or indirect morphological proofs for increased sympathetic tone in uremia. The formaldehyde-induced fluorescence method for the histochemical demonstration of catecholamines and histochemical enzyme reactions for AChE and G6PD were applied to biopsy material of parotid glands of uremic patients with known salivary electrolyte excretion and to Gl. submaxillaris of albino rats in experimental uremia. In patients with chronic uremia in the parotid parenchyma a rarefication of fluorescent adrenergic nerve terminals and a more or less pronounced depletion of catecholamine stores within them was found regularly. In experimental uremia of rats the innervation pattern remained the unchanged while the catecholamine fluorescence was clearly diminished indicating depletion of adrenergic nerve terminals as well. Quantitative estimation of the catecholamine content of various organs in experimental uremia of rats confirm our findings. Sodium balance and binding capacity of adrenergic nerve terminals for catecholamines seem to be closely associated as reported for DOCA-hypertension in rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468306
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  • 6
    Electronic Resource
    Electronic Resource
    Diagnostic haemoperfusion for rapid detection of bactaeremia (1981)
    Springer
    Journal of molecular medicine 59 (1981), S. 425-429 
    Details
    ISSN: 1432-1440
    Keywords: Haemoperfusion ; Adsorption ; Septicaemia ; Blood culture ; Antibiotic sensitivity ; Hämoperfusion ; Adsorption ; Sepsis ; Blutkultur ; Antibiogramm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 25 Patienten mit der klinischen Diagnose einer Sepsis wurde eine neue Methode des Erregernachweises mit dem sonst üblichen Blutkulturverfahren (punktuelle Blutentnahme in Blutkulturflaschen mit vorgefertigtem, flüssigem Nährmedium) verglichen. Die diagnostische Hämoperfusion mit beschichteter Aktivkohle erbrachte häufiger (16:9) einen Erregernachweis als die konventionelle Technik. Außerdem war bei positiven Blutkulturen die Keimidentifizierung und das Antibiogramm früher verfügbar. Bei sachgemäßer Anwendung bringt dieses diagnostische Verfahren für den Patienten keine Gefährdung mit sich.
    Notes: Summary The new method of diagnostic haemoperfusion was compared with the conventional blood culture technique in 25 patients with suspected septicaemia. The chance of obtaining a positive result proved to be clearly greater than that by conventional techniques (16:9). Furthermore, in the case of a positive result with the haemoperfusion technique both the bacterial identification and antibiotic sensitivities were available earlier than was previously possible. The procedure of diagnostic haemoperfusion is safe and carries a minimal risk of complications for the patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01695896
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  • 7
    Electronic Resource
    Electronic Resource
    Pneumonien bei akuten Leukämien (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 512-517 
    Details
    ISSN: 1432-1440
    Keywords: Pneumonia ; Acute leukaemia ; Immunosuppressive therapy ; Gram-negative bacteria in sputum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Acute leukaemia was complicated by pneumonia in 38 (34.8%) of 109 patients treated between 1979 and 1983; in 39.5% of the patients pneumonia occurred more than once. In 23 patients (60.5%) pneumonia occurred during cytostatic therapy, and 25 patients (65.8%) had less than 1000 mm2 granulocytes. Antibiotic therapy had no or only little effect in 70%. A total of 21 patients (55.3%) died of pneumonia. In 15 patients a direct relationship could be seen between pneumonia and the bacterial spectrum in the sputum. A prevalence of gram-negative bacteria was found (24 of 40 bacteria isolated, especially Enterobacteriaceae (19). Fungi were cultivated in 10 cases. Each of the typical pneumonia bacteria was only seen once respectively. It is most important that therapy begin immediately, even before the bacteria have been identified. Only then is there hope that the survival time of patients with acute leukaemia can be influenced.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01713058
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  • 8
    Electronic Resource
    Electronic Resource
    Septikämien bei Leukämien und malignen Lymphomen (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 821-826 
    Details
    ISSN: 1432-1440
    Keywords: Septicaemia ; Leukaemia ; malignant Lymphoma ; cytostatic Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Septicemia ocurred in 81 (=23.9%) of 339 patients with leukemias an malignant lymphomas during 1979–1984/VI. In leukemias the acute forms and in malignant lymphomas the high malignant forms were mostly affected. The frequency of gramnegative bacterias (46=56.8%) was higher than that of gram-positive bacterias (32=39.5%) and of fungus (3=3.7%). The frequency of septicemia in leukemias (alone) between 1966–1977 was 13.9%, between 1979–1984/VI 30%. In this comparison septicemias caused by gram-negative bacterias and fungus decreased, whereas gram-positive septicemias increased. The focus of septicemia remained unknown in 30 cases, Pneumonias and the urinary tract were the most common source, followed by the skin. All patients were under cytostatics and therefore leukopenic, most of them received corticosteroids simultaneously and were thus immunsuppressed. A combination of granulocytopenia 〈1,000 mm3 with hypogammaglobulinemia 〈10 rel.% were mostly found in acute leukemias and in chronic lymphatic leukemia. 41.5% of febrile episodes from all groupes of these diseases were of non-microbic origin (local or septic) an thus possibly symptom of activity of the underlying disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01732287
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  • 9
    Electronic Resource
    Electronic Resource
    Hypercalcämien bei chronisch lymphatischen Leukämien und anderen Non-Hodgkin-Lymphomen (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 791-797 
    Details
    ISSN: 1432-1440
    Keywords: Hypercalcaemia ; lymphocytic leukaemia ; Non-Hodgkin-Lymphoma ; Osteoclasts activating Factor (OAF)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three years after diagnosis of chronic lymphocytic leukaemia in a 57 year old man developed a hypercalcaemia with multiple bone fractures concomitant an increase of activity of the leukaemia. There was no hyperparathyreoidism, nor in serum, nor inside the lymphocytes. The osteopenia was caused by leukaemic infiltrations. An additional activation of osteoclasts was caused by an osteoclasts activating factor (OAF), produced by the leukaemic cells. −2 (=2.25%) of 89 Non-Hodgkin-Lymphomas except chronic lymphatic leukaemia had a moderate hypercalcaemia with concomitant activation of the underlying disease. 9 (=7.7%) of 116 chronic lymphocytic leukaemias had hypercalcaemia, 2 thereof with increased activity of the leukaemia. Hypercalcaemia is thus very rarely found in other Non-Hodgkin-Lymphomas, in chronic lymphocytic leukaemia some what more often, and only here a concomitant increase in the activity of the underlying disease could be observed in some cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01743255
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  • 10
    Electronic Resource
    Electronic Resource
    Hämoperfusion bei Flecainidintoxikation (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 442-444 
    Details
    ISSN: 1432-1440
    Keywords: Hemoperfusion ; Flecainide intoxication ; Antiarrhythmic therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 79-year-old patient, who had received a pacemaker after suffering two posterior myocardial infarctions, was treated with 2 × 100 mg flecainide daily for 9 days for ventricular extrasystoles (Lown IV b). On admission to the hospital the parameters of renal function were within the normal range. Ten days after flecainide treatment was begun a temporary electromechanic decoupling of the pacemaker occurred with reversible asystoly and progressive kidney failure. The flecainide plasma level at that time was 1460 ng/ml. Hemoperfusion for 3 h with activated charcoal removed only 35 mg flecainide in spite of an excellent flecainide clearance (164–180 ml/min). The patient's flecainide plasma level did not decrease sufficiently during the procedure, showing clearly that flecainide levels cannot be lowered fast enough by hemoperfusion to treat a flecainide intoxication.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01727530
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