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  • 1
    Electronic Resource
    Electronic Resource
    Biodegradable Porous PCL/HA Scaffolds for Bone Tissue Engineering (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 342-343 (July 2007), p. 77-80 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Poly ε-caprolactone(PCL)/hydroxyapatite(HA) composite scaffolds were fabricated byparticulate leaching and freeze drying routes with different HA content. Porosity was decreasedwith HA addition, while mean pore size was maintained at around porogen size regardless of HAcontent. Compressive modulus was increased with increasing HA content. In this study, theoptimum content of HA was around 40% in weight against PCL to obtain the highest compressivemodulus with keeping porosity above 85%. HA apparently enhanced proliferation of osteoblast-likeMG63 cells in PCL/HA composite scaffolds. Typical adhesion, migration and aggregationprocedure of MG63 cells were found on PCL, while spreading morphology only was found on HAeven at the early stage of adhesion without migration or aggregation
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.77.pdf
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  • 2
    Electronic Resource
    Electronic Resource
    Characterization of PCL/HA Composite Scaffolds for Bone Tissue Engineering (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 342-343 (July 2007), p. 109-112 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Porous and bioactive composite scaffolds based on poly ε-caprolactone(PCL) andhydroxyapatite(HA) were successfully fabricated by solvent casting and salt leaching method. Thescaffolds have interconnected pore structure with pore size ranging from 10μm to 500μm. The poresize of PCL scaffold and PCL/HA scaffold were similar to that of the salt particles. The pore wallsbecame thick and the small pores on the surface of macropores were formed as the HA increased.MTT assay showed that HA content did not affect initial cell attachment in both PCL scaffolds andPCL/HA scaffolds. The osteoblasts proliferated in both scaffolds, but the cell number was higher inthe PCL/HA composite scaffolds. It was found that the incorporation of hydroxyapatite enhancesbone cell proliferation rather than initial cell attachment in PCL/HA composite scaffolds. Theresults suggest that the PCL/HA composite scaffolds have a potential for the bone tissueengineering applications
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.109.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    In Vitro Evaluation of Poly ε-Caprolactone/Hydroxyapatite Composite as Scaffolds for Bone Tissue Engineering with Human Bone Marrow Stromal Cells (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 342-343 (July 2007), p. 369-372 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: This study evaluated the potential of the PCL (poly [removed info]-caprolactone)/HA(Hydroxyapatite)composite materials as a scaffold for bone regeneration. For this, we fabricated scaffolds utilizingsalt leaching method. The PCL/HA composite scaffolds were prepared with various HA contents(20wt%, 40wt%, 60 wt %). To ensure the potential for the scaffolds, porosity tests were conductedalong with SEM observations. The porosity decreased with the increase of the contents of HAparticles. The porosity of the composite with the highest contents of HA was still adoptable (~85%).In addition, the PCL/HA composite scaffolds were evaluated for their ability of osteogenicdifferentiation with human bone marrow stromal cell (hBMSC) in vitro. Alkaline phosphatase(ALP) activity, markers for osteoblastic differentiation, and total protein contents were evaluated inhBMSCs following 14 days of cultivation. The addition of HA particles enhanced proliferation ofhBMSC during the test. Also, the differentiation ability of the cells was increased as HA particleswere added. In this study, we concluded that PCL/HA composite scaffolds has great potential as ascaffold for bone tissue engineering
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.369.pdf
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  • 4
    Electronic Resource
    Electronic Resource
    Degradation Behaviors of β-TCP/PLGA Composites Prepared with Microwave Energy (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 342-343 (July 2007), p. 205-208 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The β-tricalcium phosphate (β-TCP)/ poly(lactide-co-glycolide) (PLGA) composites forbiodegradable scaffolds in bone tissue engineering were synthesized by in situ polymerization withmicrowave energy. The degradation behavior of β-TCP/PLGA composite was investigated bysoaking in simulated body fluid (SBF) for 4 weeks. The molecular weight of the β-TCP/PLGAcomposites decreased with soaking time until week 2, whereas the loss rate of molecular weightreduced after week 2. The incubation time was needed for the degradation of the β-TCP, indicatingthat the β-TCP should be detached from the PLGA matrix and then degraded into SBF solution. Thestudies of mass loss of the composites with the soaking time revealed that the degradation behavior ofPLGA would be processed with the transformation from the polymer to the oligomer followed by thedegradation. Morphological changes, whisker-like, due to transformation and degradation of polymerin the composites were observed after week 2. On the basis of the results, it found that thedegradation behavior of β-TCP/PLGA composites was influenced by the β-TCP content in thecomposite and the degradation rate of the composite could be controlled by the initial molecularweight of PLGA in the composite
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.205.pdf
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  • 5
    Electronic Resource
    Electronic Resource
    Tensile Properties of Cast and Hot Isostatic Pressurized Ti-6Al-4Fe-xSi Alloys (2004)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 449-452 (Mar. 2004), p. 689-692 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A new high strength titanium alloy system with low cost alloying elements, such as Al,Fe, has been recently developed. In present study the expensive V was replaced with Fe, and Si was added from 0 to 7.5wt.%. The effect of Fe and Si on the microstructure and tensile properties of Ti-6Al-4Fe-xSi (x=0, 0.1, 0.25, 0.5, 0.75wt.%) alloys was investigated. The room and high temperature mechanical properties of Ti-6Al-4Fe alloys were better than those of the Ti-6Al-4V. It was mainly due to the phase boundary strengthening at ambient and high temperature. The strength and elongation of the developed alloys depended upon the Si contents. The Si elements made the grain boundary and colony size fine, and increased the strength of the developed alloys by solid solution and precipitation hardening. The tensile strength variation with the Si contents at room temperature and 400°C, and at 450°C and 500°C showed a similar behavior, respectively
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/08/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.449-452.689.pdf
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  • 6
    Electronic Resource
    Electronic Resource
    Microstructures and Elastic Moduli of Binary Titanium Alloys Containing Biocompatible Alloying Elements (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 475-479 (Jan. 2005), p. 2291-2294 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: New titanium alloys with a low elastic modulus have been developed for biomedicalapplications to avoid the stress shielding effect of an artificial prosthesis. The newly developed alloys contained the transition elements like Zr, Hf, Nb, Ta which were non-cytotoxicity elements and β stabilizers. In the present paper the elastic moduli of Ti-xM containing Zr, Hf, Nb, Ta were evaluated by measuring the velocity of supersonic wave (Pulse Echo Overlap). The effectiveness of the alloying elements for lowering the elastic modulus was investigated. In addition, the dominant factors for the low modulus were discussed. Ta was the most effective in lowering the elastic modulus of the alloys. The effectiveness of Hf was not acceptable for decreasing the elastic modulus. The dominant factor was the lattice parameter for Zr, and the poisson's ratio for Nb, Ta, respectively, in lowering the elastic modulus of Ti
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/09/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.475-479.2291.pdf
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of β-Stabilizing Transition Elements on Elastic Modulus of Ti-M Systems (2004)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 449-452 (Mar. 2004), p. 865-868 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: New titanium alloys with a low elastic modulus have been developed for biomedicalapplications to avoid the stress shielding effect of the artificial prosthesis. The newly developed alloys contained the transition elements like Nb, Ta, Zr which were non-cytotoxicity elements. These elements produced β, ω, and α'' phases with heat treatment conditions in titanium alloys and determined the elastic modulus of the alloys. However, the clear mechanism of the low elastic modulus alloys has not been known. In the present paper, the total energy and elastic modulus of β and α'' phases were calculated using a first principle calculation employing the generalized gradient approximation (GGA). The mechanism of the low elastic modulus was discussed with calculated values
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/08/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.449-452.865.pdf
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  • 8
    Electronic Resource
    Electronic Resource
    Effect of Si Content on the Creep Properties of Ti-6Al-4Fe-xSi Alloys (2004)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 261-263 (Apr. 2004), p. 1141-1146 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Effect of silicon content on the creep properties of Ti-6Al-4Fe-xSi was studied. Creep resistance of Ti-6Al-4Fe-xSi alloys was superior to that of Ti-6Al-4V. Ti-6Al-4Fe-0.5Si alloy exhibited the highest rupture strength and creep resistance among the Ti-6Al-4Fe-xSi alloys investigated. The minimum creep rate of the alloys decreased with increasing silicon content up to 0.5wt.% and then it increased again when the silicon content was higher than 0.5wt.%. TiFe precipitates were formedmainly at the β phase area of Ti-6Al-4Fe-xSi alloys by consuming titanium and iron in β phase, when the alloys were thermally exposed at 500 and 600°C during the creep test. During the creep test, microvoids were induced at the TiFe/α phase interfaces and the cracks were formed along the TiFe/α phase interfaces by the coalescence of the voids. Those cracks were finally connected each other through the α phase
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/47/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.261-263.1141.pdf
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  • 9
    Electronic Resource
    Electronic Resource
    Fabrication of Hierarchically Porous Bioactive Glass Ceramics (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 361-363 (Nov. 2007), p. 285-288 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Hierarchically 3D porous bioactive glasses (BGs) with various combination of bothpore sizes and pore structures have been produced by multi-polymer templating, such asamphiphilic block copolymers, poly urethane (PU) forms, poly styrene (PS) beads, or methylcellulose (MC), sol-gel method, evaporation-induced self-assembly process, and rapid prototypingtechnique. The amphiphilic block copolymers used for producing the meso pores into the BGs,which induces large specific surface area and subsequently carries with good bone-formingbioactivity of BGs. Each poly urethane form, poly styrene bead, and methyl cellulose adapted forthe fabrication of macro pores. The rapid prototyping (RP) techniques introduced to produce 3DBGs scaffolds with giant pores
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.361-363.285.pdf
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