Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Effect of CNTF on ischaemic cell damage in rat hippocampus (1996)
    Springer
    Acta neurochirurgica 138 (1996), S. 580-583 
    Details
    ISSN: 0942-0940
    Keywords: Ciliary neurotrophic factor (CNTF) ; cerebral ischaemia ; delayed neuronal cell death ; rat hippocampus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The neuroprotective effect of neurotrophic factors has been demonstrated in experimental cerebral ischaemia recently. These include nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1), and basic fibroblast growth factor (basic FGF). The neuroprotective effect of ciliary neurotrophic factor (CNTF), however, has not been studied so far. We have examined the neuroprotective effect of recombinant rat CNTF in a rat forebrain ischaemia model. A continuous infusion of CNTF was started 1 week before the induction of ischaemia and continued until 1 week after the ischaemia. Reversible forebrain ischaemia was induced by 7 minutes of bilateral carotid occlusion with hypotension. Neuronal cell death in the hippocampal CA1 sector was evaluated 1 week after the ischaemia. For the control group artificial CSF (cerebrospinal fluid) was infused instead of CNTF. Per cent neuronal cell death was 83.4 ± 5.9% (mean ± SEM, n=5) in the control group, and 71.1 ± 10.0% (mean ± SEM, n=5) in the CNTF group. Although percentage of neuronal cell death was lower in the CNTF group, the difference was not statistically significant. This result suggests that the protective effect of CNTF in the rat forebrain ischaemia model may be limited compared with other neurotrophic factors. It is considered that the number of neurons protected by CNTF may be small.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01411179
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Thermal diffusion blood flow monitoring during aneurysm surgery (1996)
    Springer
    Acta neurochirurgica 138 (1996), S. 726-731 
    Details
    ISSN: 0942-0940
    Keywords: Thermal diffusion ; cerebral blood flow ; temporary clipping ; cerebral aneurysm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cortical blood flow (CoBF) monitoring with a thermal diffusion flow probe was performed during the clipping of aneurysms of the ICA and MCA regions, on a series of patients during the acute stage of subarachnoid haemorrhage. Emphasis was placed on the CoBF recovery after temporary clip release. Since the absolute value in this technique is unreliable, recovery of blood flow after temporary clipping is represented as %CoBF according to the following equation: %CoBF recovery = (CoBFpost-CoBFintra)/(CoBFpre-CoBFintra) Presumably, this parameter checks the patency of the concerned cerebral vessels during clipping and/or release. Percent recovery of more than 100%, indicating postischaemic reactive hyperaemia, was observed immediately after release of the temporary clips in 8 of the 9 cases evaluated. In one case, with prolonged temporary clipping (37 min), no immediate recovery was observed after clip release, suggesting no-reflow phenomenon. The value slowly recovered after local administration of papaverin and returned to the pre-occlusion level within 20 minutes. Thermal diffusion CoBF monitoring may be useful in detecting the possible no-reflow phenomenon, that may lead to ischaemic complication, even after successful aneurysm clipping.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01411479
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Correlation Between Jugular Bulb Oxygen Saturation and Partial Pressure of Brain Tissue Oxygen During CO2 and O2 Reactivity Tests in Severely Head-Injured Patients (1999)
    Springer
    Acta neurochirurgica 141 (1999), S. 825-834 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Head injury; brain tissue oxygen pressure; jugular bulb oxygen saturation; CO2 and O2 reactivity.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  Purpose. To correlate the jugular bulb oxygen saturation (SjvO2) and brain tissue oxygen pressure (PbtO2) during carbon dioxide (CO2) and oxygen (O2) reactivity tests in severely head-injured patients.  Methods and Results. In nine patients (7 men, 2 women, age: 26±6.5 years, GCS of 6.5±2.9), a polarographic microcatheter (Clark-type) was inserted into nonlesioned white matter (frontal lobe). PbtO2 and SjvO2 were monitored simultaneously and cerebral vasoreactivity to CO2 and O2 was tested on days three, five and seven after injury. Simultaneous measurements of vasoreactivity by transcranial Doppler (TCD) were undertaken. A total of twenty-one CO2 and O2 reactivity tests were performed. Critical values of PbtO2 (〈15 mm Hg) during induced hyperventilation could be observed four times in two patients. High PbtO2 values up to 80 mm Hg were observed during hyperoxygenation (FiO2 100%). CO2 vasoreactivity by means of PbtO2 was absent in four tests in which measurements by TCD showed intact responses. A stronger correlation between SjvO2 and PbtO2 during the O2 reactivity tests was observed (r=0.6, p〈0.001), in comparison to values obtained during the CO2 reactivity tests (r=0.33, p〈0.001). In addition, there was no statistically significant correlation (r=0.22, p=0.26) between CO2 reactivity values measured by TCD (4.5±5.7%) and PbtO2 (3±2.8%).  Conclusions. Correlation between SjvO2 and PbtO2 during CO2 reactivity test is low, even if significant differences between normo- and hyperventilation values are present. In comparison to SjvO2, monitoring of PbtO2 might more accurately detect possible focal ischaemic events during rapidly induced hyperventilation in severely head-injured patients. The CO2 vasoreactivity by means of changes in Vm MCA seems to be higher in comparison to changes of PbtO2. These observations lead to the hypothesis that vasoreactivity measured by TCD overestimates the cerebrovascular response to CO2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050383
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    The diagnosis of solitary primary reticulum cell sarcoma of the posterior fossa with computed tomography (1981)
    Springer
    Neuroradiology 21 (1981), S. 213-217 
    Details
    ISSN: 1432-1920
    Keywords: Brain neoplasms, diagnosis ; Cerebellum, neoplasms ; Computed tomography, head ; Sarcoma ; Reticulum cell sarcoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The CT findings in two surgically and histologically verified cases of primary reticulum cell sarcoma of the cerebellar hemisphere with secondary involvement of the cerebellopontine angle are presented. It is suggested that a correct diagnosis is possible by CT if the following criteria are present: 1. slightly increased attenuation of the mass on the precontrast scan; 2. mottled appearance of the definitely enhancing mass; 3. ill-defined borders on both the pre-and postcontrast scans; 4. degree of mass effect less than that expected from the size of the lesion; 5. involvement of the cerebellopontine angle without signs indicating an extra-axial origin of the tumor. These criteria reflect the gross and microscopic neuropathological features of the tumor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00367343
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Das Neurotrauma – Aktuelles Behandlungskonzept (1996)
    Springer
    Der Unfallchirurg 99 (1996), S. 806-810 
    Details
    ISSN: 1433-044X
    Keywords: Schlüsselwörter Neurotrauma ; Zerebrale Substratversorgung ; Pathophysiologie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001130050059
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...