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  • 1
    Electronic Resource
    Electronic Resource
    The assessment of the beta-blocking activity of urapidil: A new method (1986)
    Springer
    European journal of clinical pharmacology 31 (1986), S. 149-154 
    Details
    ISSN: 1432-1041
    Keywords: urapidil ; volunteers isoproterenol dose response analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Urapidil is an antihypertensive vasodilator agent whose pharmacological action in man has not yet been fully defined. We have assessed the beta blocking activity of urapidil 15 mg and 30 mg i.v. in a single blind study of 10 healthy male volunteers. Urapidil at plasma concentrations in the same range as those shown to have antihypertensive affect did not significantly attenuate the chronotropic effect of isoproterenol. Propranolol 5 mg iv, the positive control, significantly shifted the isoproterenol dose-response curve to the right. We describe a new method of analyzing incomplete dose response curves whereby a linear terminal segment can be reproducibly defined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00606651
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  • 2
    Electronic Resource
    Electronic Resource
    Level shifts of discrete states embedded in a continuum (1989)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 91 (1989), S. 2980-2982 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: A procedure which offers computational advantages over the customary formalism is presented for calculating the shifts of the energy levels of discrete states embedded in a continuum. Numerical procedures are described and applied to the vibrational level shifts of the B 3Σ−u state of 16O2 interacting with the 5Πu continuum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.456968
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  • 3
    Electronic Resource
    Electronic Resource
    Time-dependent quantum mechanical study of photodissociation of molecular oxygen in the Schumann–Runge continuum (2000)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 112 (2000), S. 1255-1259 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We present a time-dependent quantum mechanical investigation of predissociation of molecular oxygen following absorption in the Schumann–Runge continuum. We calculate the total and partial photoabsorption cross sections in a wave packet formalism in which the predissociation of the B 3Σu− molecular state is attributed to spin-orbit interactions with the 1Πu, a 3Πu, 5Πu, and 2 3Σu+ repulsive states. We calculate the branching ratio, describing the relative rates of production of excited (1D) and ground-state (3P) oxygen atoms, and find close agreement with a recent measurement. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.480657
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  • 4
    Electronic Resource
    Electronic Resource
    Predissociation of oxygen in the B 3Σ−u state (1992)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 97 (1992), S. 1787-1792 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The predissociation linewidths and level shifts of vibrational levels of three oxygen isotopic molecules 16O2, 16O18O, and 18O2 arising from the interactions of the B 3Σ−u state with the four repulsive states 5Πu, 3Σ+u, 3Πu, and 1Πu, have been calculated. A set of parameters characterizing these interactions has been determined. Good agreement between calculated and experimental predissociation widths and shifts has been obtained for all the three isotopic molecules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.463165
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  • 5
    Electronic Resource
    Electronic Resource
    Rotational dependence of the predissociation linewidths of the Schumann–Runge bands of O2 (1993)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 99 (1993), S. 1086-1092 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The predissociation linewidths of vibrational levels v=0 –12 for 16O2, 16O18O, and 18O2 molecules in the B 3Σu− state with rotational quantum numbers N≤20 have been calculated taking into account the spin–orbit interactions of the B 3Σu− state with the 5Πu, 3Σu+, 3Πu, and 1Πu states, and the rotational coupling with the 3Πu state. The predissociation linewidths exhibit systematic variations with rotational quantum number for different vibrational levels. Good agreement between most of the calculated and experimental linewidths has been obtained for all three isotopic molecules, with the exception of the set of linewidths of 16O2 for v=0 and 2. The agreement can be improved by adjustment of the 1Πu potential and the strength of the spin–orbit interaction between the B 3Σu− and 1Πu states.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.466204
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  • 6
    Electronic Resource
    Electronic Resource
    Isotopic dependence of predissociation linewidths in the Schumann-Runge bands of oxygen (1995)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 103 (1995), S. 2369-2371 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: It is demonstrated that, according to semi-classical theory, the isotopic dependence of the predissociation linewidths in the Schumann-Runge bands of oxygen cannot be removed by simple scaling of the reduced mass. This is in contrast to the isotopic dependence of the predissociated vibrational energy levels. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.469660
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  • 7
    Electronic Resource
    Electronic Resource
    The local effects of systemic digoxin on the cutaneous microcirculation (1999)
    Springer
    European journal of clinical pharmacology 55 (1999), S. 263-268 
    Details
    ISSN: 1432-1041
    Keywords: Key words Digoxin ; Laser Doppler fluximetry ; Endothelium-dependent vasodilation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: The present study was designed to explore whether digoxin modifies cutaneous vascular responses to an endothelium-dependent vasodilator (acetylcholine) or to the vasoconstrictor norepinephrine. Methods: In a double-blind cross-over study 12 healthy subjects received digoxin 0.25 mg twice daily (after adequate loading doses) or placebo for a total of 11 days. Dose-response curves to iontophoresis of acetylcholine or norepinephrine were constructed at day 11. Laser Doppler flux (LDF) was measured at the same sites. Mean arterial pressure (MAP) was measured non-invasively and cutaneous vascular conductance (CVC) was calculated (CVC=LDF/MAP). Results: Serum concentrations of digoxin were within the therapeutic range [1.3 (0.5) ng · ml−1; mean with (SD)]. Blood pressure and heart rate were significantly lower during supine rest under digoxin treatment [mean with (SD); minute 10 to 70 of supine rest; systolic blood pressure: 121 (11) mmHg (placebo) vs 116 (11) mmHg (digoxin); P = 0.001; diastolic blood pressure: 63 (6) mmHg vs 58 (8) mmHg; P = 0.007; heart rate: 60 (10) beats · min−1 vs 54 (8) beats · min−1; P = 0.001]. Digoxin also caused significantly higher baseline CVC [169 (25) Perfusion Units (PU) · mmHg−1 (digoxin) vs 109 (14) PU · mmHg−1 (placebo); P = 0.013] and significantly increased the vasoconstriction to norepinephrine iontophoresis. Acetylcholine iontophoresis was unaltered by digoxin treatment. Conclusions: Digoxin does not modify the cutaneous vascular response to an administered endothelium-dependent vasodilator. It reduces resting heart rate, blood pressure and baseline cutaneous blood flow and augments the vasoconstrictive effect of exogenous norepinephrine. The findings do not support the hypothesis that digoxin lowers diastolic blood pressure through a direct action on blood vessels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050627
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