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  • 1
    Electronic Resource
    Electronic Resource
    Koexistenz von Knocheninfarkt und aggressiver Knochenmetastase (1997)
    Springer
    Der Unfallchirurg 100 (1997), S. 69-72 
    Details
    ISSN: 1433-044X
    Keywords: Schlüsselwörter Knocheninfarkt ; Adenokarzinom ; Metastase ; Koexistenz ; Key words Bone ; Infarction ; Adenocarcinoma ; Metastasis ; Coexistence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: A 42-year-old male patient presented with a history of persistent pain in the right femur without trauma of 2 months, duration and an episode of bloody stools 3 months earlier with no clinical findings upon examination. X-rays and CT scan revealed a circumscribed lesion with sclerosis and periostal reaction in the right proximal femur. A three-phase bone scan showed a massive hot spot in this area. Primarily differential diagnoses included a Brodie's abscess and/or a tumor. An excisonal biopsy of the area was performed and revealed the coexistence of a bone infarction and the metastasis of an adenocarcinoma of unknown origin. The lesion in the bone was resected, filled with autogenous cancellous bone and stabilized with a plate. Further intensive screening with CT of the abdomen, gastroscopy and colonoscopy led to the primary tumor, an adenocarcinoma at the rectosigmoidal junction. No other metastases were detected. This patient presented with severe pain an radiologically divergent findings: a presumably benign process on radiography, but a massive hot spot on scintigraphy. Further procedures such as a CT scan and/or MRI had to be undertaken. If the analysis includes the differential diagnosis of a malignant process, a biopsy must be obtained, and if this reveals a metastasis, the primary tumor must be sought.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001130050096
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  • 2
    Electronic Resource
    Electronic Resource
    Primary chronic osteomyelitis (1997)
    Springer
    Der Orthopäde 26 (1997), S. 889-893 
    Details
    ISSN: 1433-0431
    Keywords: Key words Primary chronic osteomyelitis • Subacute chronic osteomyelitis • Unifocal chronic osteomyelitis • Plasma cell osteomyelitis • Chronic recurrent multifocal osteomyelitis • SAPHO syndrome ; Schlüsselwörter Primäre chronische Osteomyelitis • Plasmazelluläre Osteomyelitis • Subakute Osteomyelitis • Unifokale chronische Osteomyelitis • Chronische rekurrierende multifokale Osteomyelitis • SAPHO-Syndrom
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Unter dem Begriff der primären chronischen Osteomyelitis werden verschiedene Krankheitsbilder zusammengefaßt, die aus therapeutischen Gründen getrennt werden sollten. Unifokale Formen können von multifokalen Manifestationen unterschieden werden. Während die ersteren oft bakteriell bedingt sind, läßt sich bei der 2. Gruppe kein Erreger nachweisen. Besonders die multifokalen Formen (chronische rekurrierende multifokale Osteomyelitis, CRMO) neigen zum Rezidiv, langem Verlauf und können zusätzlich eine Hautbeteiligung zeigen (SAPHO-Syndrom). Die Biopsie dient in erster Linie zum Tumorausschluß und zur Materialgewinnung für die bakteriologische Untersuchung. Histologische Unterscheidungsmöglichkeiten zwischen diesen chronischen Osteomyelitisformen gibt es nicht.
    Notes: Summary The term primary chronic osteomyelitis covers a heterogeneous spectrum of clinical features that should be separated for therapeutic reasons. Unifocal manifestations should be distinguished from multifocal ones. While bacteria are often found in the first group, bacteriological investigations are usually negative in the second group. Additionally, multifocal forms often recur (chronic multifocal recurrent osteomyelitis), possess a long clinical course and may be combined with dermatological disorders (SAPHO syndrome). A biopsy is often necessary for tumor exclusion and obtaining material for bacteriology. Histology cannot differentiate between the respective forms of chronic osteomyelitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00003338
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  • 3
    Electronic Resource
    Electronic Resource
    Small cell neuroendocrine (oat cell) carcinoma of the male breast (1984)
    Springer
    Virchows Archiv 404 (1984), S. 213-221 
    Details
    ISSN: 1432-2307
    Keywords: Oat cell carcinoma ; Male breast ; Immunocytochemistry ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of small cell neuroendocrine (oat cell) carcinoma of the breast in a 52-year old male is presented. Oat cell carcinomas have been reported in various extrapulmonary sites, but this is the second case of a primary oat cell carcinoma of the breast and the first one to have been documented in a male. The tumor was investigated histologically, immunocytochemically and ultrastructurally. The relationship to so-called “carcinoid” mammary tumors is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00704065
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  • 4
    Electronic Resource
    Electronic Resource
    Immunocytochemical identification of osteogenic bone tumors by osteonectin antibodies (1989)
    Springer
    Virchows Archiv 414 (1989), S. 345-353 
    Details
    ISSN: 1432-2307
    Keywords: Bone tumors ; Osteosarcoma ; Osteonectin ; Immunocytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 18 bone-forming tumours and tumour-like lesions were investigated immunocytochemically for the presence of osteonectin. A group of non-bone-forming skeletal tumours (five cartilage-forming tumours, four Ewing sarcomas and five extraskeletal sarcomas) served as controls. The studies showed that osteonectin antibodies react reliably with benign and malignant bone-forming tumours (two cases of fibrous dysplasia, three osteoid osteomas, 13 osteosarcomas). This finding was supported by protein blot studies. Osteonectin is formed by cells which do not yet possess the morphological phenotype of osteoblasts and may be regarded as a “differentiation marker” of the osteoblastic lineage. Only chondroid bone (tissue in which chondrocytes were surrounded by osteoid matrix containing type I and type II collagen) showed a positive reaction. All other primary skeletal tumours and extraskeletal soft tissue tumours were completely negative.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00734090
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  • 5
    Electronic Resource
    Electronic Resource
    In situ measurement of collagen synthesis by human bone cells with a Sirius Red-based colorimetric microassay: effects of transforming growth factor β2 and ascorbic acid 2-phosphate (1999)
    Springer
    Histochemistry and cell biology 112 (1999), S. 271-276 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  Staining of collagens by Sirius Red, a standard histological procedure, was applied to quantify collagen synthesis in human osteoblast-like cell cultures in situ. After morphological analysis of the deposited material, the stain was dissolved and its optical density determined spectrophotometrically using a microtiter plate assay system. The method was sensitive with a detection limit for collagen synthesized by 3000 normal human periosteal cells. The assay is easy to perform and specific with respect to different extracellular materials, for example, collagen types I and III were well stained, collagen type IV and laminin exhibited only low staining, and fibronectin, chondroitin sulfate, dermatan sulfate, and amyloid β were negative. A major advantage of the method is the combination of identification of collagen-producing cells in situ with subsequent spectrophotometric quantification of the dissolved stain. Thus it is possible to obtain information on cell morphology, active sites of collagen deposition in a cell culture, microscopic detection of high-and low-producer cells prior to dissolution and quantification of the deposited material. In this regard the assay is superior to either radioactive labeling, hydroxyproline determination, or Sirius Red-based colorimetric assays with cell lysates. Since the quantification is based on microtiter plate reading, the method can be recommended for the screening of large quantities of samples.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004180050447
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  • 6
    Electronic Resource
    Electronic Resource
    Pigmentierte villonoduläre Synovitis des Kiefergelenks mit Einbruch in die mittlere Schädelgrube (1998)
    Springer
    Mund-, Kiefer- und Gesichtschirurgie 2 (1998), S. 279-281 
    Details
    ISSN: 1434-3940
    Keywords: Schlüsselwörter Pigmentierte villonoduläre Synovitis ; Tenosynovialer Riesenzelltumor ; Kiefergelenk ; Schädelbasis ; Key words Giant-cell tumor ; Pigmented villonodular synovitis ; Temporomandibular joint ; Skull base
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: A 63-year-old man is presented in whom a tenosynovial giant-cell tumor destroyed the right temporomandibular joint and fossa and showed extensive intracranial growth. Because of uncharacteristic complaints, a symptomatic treatment was performed elsewhere. The lesion was finally resected under endotracheal anesthesia. After 20 months free of recurrence the patient’s outcome is very satisfying. Differential diagnosis and therapy are discussed.
    Notes: Der Fall eines 63jährigen Manns mit einer pigmentierten villonodulären Synovitis wird beschrieben. Bedingt durch expansives Tumorwachstum kam es zur Destruktion der rechten Kiefergelenkpfanne und zum Einbruch in die mittlere Schädelgrube. In der Vorgeschichte erfolgte auswärts, aufgrund uncharakteristischer Symptome, eine rein symptomatische Behandlung. Schließlich wurde in Intubationsnarkose eine Tumorresektion durchgeführt. Der Patient ist 20 Monate rezidivfrei und mit dem Therapieergebnis zufrieden. Differentialdiagnose und Therapie werden diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100060050075
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  • 7
    Electronic Resource
    Electronic Resource
    Unizystische Ameloblastome im frühen Wachstumsalter (1998)
    Springer
    Mund-, Kiefer- und Gesichtschirurgie 2 (1998), S. 213-215 
    Details
    ISSN: 1434-3940
    Keywords: Schlüsselwörter Unizystisches Ameloblastom ; Kleinkind ; Key words Unicystic ameloblastoma ; Young child
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Two cases of unicystic ameloblastoma in the mandible of young children are described. Conservative surgery is justified in children due to the lower risk of recurrence compared to cases of solid ameloblastoma and the risk of growth disturbance after radical surgery. However, long-term follow-up is necessary.
    Notes: Zwei Kasuistiken von unizystischen Ameloblastomen im Unterkiefer bei Kleinkindern werden beschrieben. Aufgrund der im Vergleich zu soliden Ameloblastomen geringeren Rezidivneigung nach Enukleation und der Gefahr von Wachstumsstörungen nach radikaler Entfernung ist bei Kindern eine konservative Chirurgie gerechtfertigt. Langfristige Nachkontrollen sind jedoch notwendig.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100060050061
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  • 8
    Electronic Resource
    Electronic Resource
    Knochentumoren und tumorähnliche Läsionen im Kiefer (2000)
    Springer
    Mund-, Kiefer- und Gesichtschirurgie 4 (2000), S. S196 
    Details
    ISSN: 1434-3940
    Keywords: Schlüsselwörter ; Odontogene Tumoren ; WHO-Klassifikation ; DÖSAK ; Kiefer ; Fibröse Dysplasie ; Zemento-ossifizierendes Fibrom ; Zemento-ossäre Dysplasie ; Zentrales Riesenzellgranulom ; Cherubismus ; Knochenzysten ; Knochentumoren ; Knorpeltumoren ; Ewing-Sarkom ; Plasmozytom ; Malignes Lymphom ; Radiologie ; Histologie ; Key words ; Odontogenic tumors ; WHO classification ; DÖSAK ; Jaws ; Fibrous dysplasia ; Cemento-ossifying fibroma ; Cemento-osseous dysplasia ; Central giant cell granuloma ; Cherubism ; Bone cysts ; Bone forming tumors ; Cartilage forming tumors ; Ewing sarcoma ; Plasmocytoma ; Malignant lymphoma ; Radiology ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Within this chapter, tumors which produce bone matrix (osteoid) or other bone-forming tissues, like cartilage, connective tissue, and cementum or originate within the bone marrow are described. In addition, those lesions are mentioned which, according to the WHO, are typical for the jawbones and are therefore included within the 1992 WHO classification of odontogenic tumors. Vascular and epithelial tumors which may also be observed in the jaws are not described. All the lesions and tumors reported have in common a more or less similar clinical and radiological appearance. A precise diagnosis, therefore, can only be established by a sufficient biopsy which should be seen by a pathologist with experience in this field. In addition to clinical, radiological, and histological appearances, therapeutic necessities are described. The data from recent publications are taken into account. This presentation is based on the data collected within the reference registry of the German-Austrian-Swiss Study Group of Tumors of the Face and Jaws (DÖSAK) in Basel.
    Notes: Zusammenfassung Im vorliegenden Kapitel werden die Tumoren dargestellt, die in ihrer Differenzierung Knochenmatrix (Osteoid) und andere knochentypische Gewebe wie Knorpel, Bindegewebe und Zement bilden oder im Knochenmark vorkommen. Zusätzlich sind diejenigen Läsionen aufgeführt, welche von der WHO als für die Kieferknochen typisch bezeichnet und deshalb in die 1992 erschienene Klassifikation odontogener Tumoren aufgenommen worden sind. Vaskuläre und im Knochen vorkommende epitheliale Tumoren werden nicht behandelt. Den hier erwähnten Läsionen und Tumoren ist eine sowohl klinische als auch radiologische Symptomarmut gemeinsam. Eine zuverlässige Diagnose ist daher ohne ausreichende Biopsie, die von einem spezialisierten Pathologen untersucht werden sollte, nicht möglich. Neben der Klinik sind das radiologische und histologische Erscheinungsbild unter Berücksichtigung neuerer Literatur beschrieben, zudem wird das therapeutische Vorgehen erwähnt. Die vorliegende Darstellung der wichtigsten Knochentumoren und tumorähnlichen Läsionen im Kiefer basiert auf ¶den im Basler Referenzregister des Deutsch-Österreichisch-Schweizerischen Arbeitskreises für Tumoren im Kiefer-Gesichts-Bereich (DÖSAK) gesammelten Unterlagen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00014541
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  • 9
    Electronic Resource
    Electronic Resource
    Discrete synchronous multifocal osteoid osteoma of the humerus (1996)
    Springer
    Skeletal radiology 25 (1996), S. 667-670 
    Details
    ISSN: 1432-2161
    Keywords: Key words Osteoid osteoma ; Multifocal occurrence ; Humerus ; Excision ; MRI findings
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A 24-year-old patient is described who had a 4-year history of pain in the right upper arm, with distinct night pain, that responded to salicylates. From the findings on conventional radiography, bone scintigraphy and MRI a multifocal osteoid osteoma was suspected, with one focus in the cancellous region of the greater tuberosity and a second cortical focus at the proximal humeral diaphysis. The resection ’’en bloc’’ of both tumors and histological examination confirmed the diagnosis. The patient was painfree after the curative resection of the two osteoid osteomas. Osteoid osteoma is a frequently found benign bone tumor, accounting for approximately 11% of cases. In rare cases a multicentric occurrence has been described. A possible occurrence of more than one osteoid osteoma in a single bone, not verified histologically, has been reported only three times in the literature. In patients with scintigraphic and radiographic findings of two foci, discrete synchronous multifocal osteoid osteomas should be suspected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002560050155
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  • 10
    Electronic Resource
    Electronic Resource
    High dosage desferrioxamine therapy in a female patient with acquired aplastic anaemia and transfusion siderosis (1986)
    Springer
    Annals of hematology 52 (1986), S. 211-219 
    Details
    ISSN: 1432-0584
    Keywords: Desferrioxamine ; Aplastic anaemia ; Transfusion siderosis ; Faecal iron excretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 32 year old woman with severe aplastic anaemia required frequent transfusions and consequently developed hyperferrioxaemia (54 μMol/l) and hyperferritinaemia (1,700 ng/ml). For the treatment of transfusion siderosis she was given 18 high dose courses each comprising 35 g of desferrioxamine. Because of pre-existing thrombocytopenia (platelet count 5×109/l) the iron chelating agent was given by continuous intravenous infusion over 3 1/2 days. High dose desferrioxamine had to be abandoned because of severe bone pain. The desferrioxamine infusions achieved a negative iron balance, iron loss after each infusion being 100 to 200 mg in the urine and 400 mg in the faeces. Serum iron and ferritin concentrations fell almost to normal. This report shows that faecal iron excretion must be taken into account in assessing the balance of iron input and output during desferrioxamine treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00321080
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