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  • 1
    Electronic Resource
    Electronic Resource
    Der cytochemisch ermittelte Leukosetyp als prognostischer Parameter bei unreifzelligen Leukosen (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 134-137 
    Details
    ISSN: 1432-1440
    Keywords: Acute leukaemia ; classification ; effect of therapy ; prognosis ; Unreifzellige Leukosen ; Klassifizierung ; Therapieeffekt ; Prognose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Komplette Remissionen und Überlebenszeiten von 81 Patienten mit unreifzelligen (akuten) Leukosen wurden zwischen Gruppen, die nach cytochemischen Kriterien ermittelt worden waren, verglichen. Die Klassifizierung erfolgte nach den Ergebnissen von PAS-, Peroxydase-und Esterase-Reaktionen. Eine signifikant höhere Rate an kompletten Remissionen und längere Überlebenszeiten wurden bei den Leukosen vom PAS-Typ im Vergleich zu allen anderen Formen festgestellt. Bei Erwachsenen und Kindern unterschied sich dieser Leukosetyp in der Remissionsrate nicht. Hieraus wird die Forderung abgeleitet, daß Erwachsene mit Leukosen vom PAS-Typ dieselbe intensive Behandlung erfahren sollten wie Kinder.
    Notes: Summary 81 cases of acute leukaemia were classified according to cytochemical criteria. PAS, peroxidase and esterase reactions were used for classification. Rates of complete remissions and duration of survival after diagnosis in the different groups were compared. A significant higher rate of complete remissions and longer duration of survival was detected in PAS type leukaemias compared to all the other types in adults. There was no significant difference in the remission rates between PAS type leukaemias in children and adults treated for at least 7 days. These results lead to the conclusion that adults with this type of acute leukaemia should receive the same treatment as children do.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01620751
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  • 2
    Electronic Resource
    Electronic Resource
    Behandlungsergebnisse mit dem ABVD-Schema bei C-MOPP-resistentem Morbus Hodgkin (1981)
    Springer
    Journal of molecular medicine 59 (1981), S. 267-273 
    Details
    ISSN: 1432-1440
    Keywords: Hodgkin's disease ; MOPP-failures ; ABVD ; Morbus Hodgkin ; MOPP-Resistenz ; ABVD
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 22 Patienten wurden mit dem ABVD-Protokoll behandelt. 19 (18 × IV B, 1 × III B) sind auswertbar. Kein Patient mit eingeschränkter, aber 7 von 13 Patienten mit intakter Knochenmarksfunktion erreichten eine Vollremission. Alle vier Patienten mit therapie- und krankheitsfreiem Intervall aber nur von 3 von 13 Patienten ohne freies Intervall erreichten ebenfalls eine Vollremission. Vorbehandlung, Histologie, Dauer der Erkrankung und Lebensalter hatten keinen eindeutigen Einfluß auf die Remissionszahlen. Die Toxizität war insbesondere bei über 50-jährigen Patienten erheblich. Zwei Patienten dieser Altersgruppe brachen die Therapie wegen gastrointestinaler Nebenwirkungen ab und 2 von 8 starben an ABVD-mitverursachten Erkrankungen (1 Leukämie, 1 plötzlicher Herztod). Bei drei Patienten mit hochdosierter Mediastinalbestrahlung war eine Pneumonitis eine der wesentlichen Todesursachen. Nach unseren Ergebnissen ist ABVD ein effektives Chemotherapieprotokoll für einige Subgruppen der „MOPP-Versager“.
    Notes: Summary 22 patients were treated with ABVD, 19 (18 stage IV B 1 stage III B) could be evaluated. No patient with impaired but 7 of 13 patients with intact bone-marrow function achieved a complete remission. A complete remission was also achieved by all 4 patients with a treatment- and disease-free interval but only by 3 of 15 without a free interval. Pretreatment, histology, duration of disease, and age showed no clear prognostic significance with respect to induction of remission. Toxicity was severe especially in patients over 50 years of age. 2 patients discontinued therapy because of gastro-intestinal toxicity. 2 of 8 died of treatment-related causes (1 leukemia, 1 sudden cardiac death). In 3 patients with high-dose mediastinal irradiation a pneumonitis secondary to bleomycin contributed significantly to death. Our results suggest that ABVD is an effective salvageregimen for some subgroups of MOPP-failures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01478205
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  • 3
    Electronic Resource
    Electronic Resource
    Cytochemical and biochemical demonstration of an alkaline phosphatase in human red cells (1970)
    Springer
    Journal of molecular medicine 48 (1970), S. 763-764 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In den Erythrocyten und Erythroblasten von drei Mitgliedern einer Familie mit Polyglobulie wurde alkalische Phosphatase nachgewiesen. Die stärkste Aktivität fand sich in den Erythroblasten des Knochenmarkes.K m -Wert und elektrophoretische Wanderungsgeschwindigkeit des extrahierten Erythrocytenenzyms in Gelen unterscheiden sich von den Werten der alkalischen Neutrophilenphosphatase. Zumindest ein Teil des Enzyms ist an die Erythrocytenmembran oder das Erythrocytenstroma gebunden.
    Notes: Summary Activity of alkaline phosphatase has been demonstrated in the red cells of three members of a family with erythrocytosis. The highest activity is found in the cytoplasm of erythroblasts in bone marrow.K m value and migration velocity of the extracted erythrocyte enzyme in gels differ from that of leukocyte alkaline phosphatase. At last part of the enzyme is bound to red cell membrane or stroma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01497139
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  • 4
    Electronic Resource
    Electronic Resource
    Plasmazelleinschlüsse bei Mangel an saurer Maltase (Glycogenose Typ II) (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 653-654 
    Details
    ISSN: 1432-1440
    Keywords: Glycogenosis type II-acid maltase deficiency ; plasma cells ; lymphocytes ; inclusion bodies ; electron microscopy ; microspectrophotometry ; cytochemistry ; Glykogenose II — (Saurer Maltasemangel) ; Plasmazellen ; Lymphocyten ; Einschlüsse ; Elektronenmikroskopie ; Mikrospektrophotometrie ; Cytochemie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei Glykogenose II — Sauerer Maltasemangel — wurden bei einem erwachsenen Patienten regelmäßig Vacuolen in Plasmazellen und vereinzelt in Lymphocyten gefunden, die nach elektronenmikroskopischen, mikrospektrophotometrischen und cytochemischen Untersuchungen Glykoproteideinschlüssen entsprechen.
    Notes: Summary Vacuoles could be demonstrated in nearly all plasma cells and in some lymphocytes of an adult with glycogenosis type II-acid maltase deficiency. Electronmicroscopical, microspektrophotometrical, and cytochemical investigations revealed glycoproteid inclusions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468804
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  • 5
    Electronic Resource
    Electronic Resource
    Therapieergebnisse des Morbus Hodgkin in den Stadien I und II (1981)
    Springer
    Journal of molecular medicine 59 (1981), S. 469-475 
    Details
    ISSN: 1432-1440
    Keywords: Hodgkin's disease ; Treatment results ; Prognostic factors ; Morbus Hodgkin ; Therapieergebnisse ; Prognostische Faktoren
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Behandlungsergebnisse des Morbus Hodgkin der Stadien I und II werden durch Vergleich der Überlebensdaten der Literatur nach verschiedenen Strahlentherapieprogrammen und nach zusätzlicher Chemotherapie diskutiert. Im Stadium I A bleiben 90–97% und im Stadium II A 75–80% der Patienten nach ausgedehnter Strahlentherapie rezidivfrei. Für das Stadium IIB werden 0–80% langdauernde Remissionen nach alleiniger Strahlentherapie berichtet. Zusätzliche Chemotherapie verbessert die Rezidiv-, aber nicht die Überlebenszahlen der Stadien I und II. Gruppen mit hohem Rezidivrisiko (große Mediastinaltumoren, E-Befall der Lunge und lymphozytenarme Histologie) werden dargestellt.
    Notes: Summary The results obtained in the treatment of Hodgkin's disease, stages I and II, are discussed comparing survival data of the literature after various radiotherapy programs and after combined modality using additional chemotherapy. In stage I A 90 to 97% and in stage II A 75 to 80% of patients are not prone to relapse after extended-field irradiation. In stage IIB 0 to 80% long-lasting remissions are reported after radiotherapy. Additional chemotherapy improved relapse-free survival, but not overall survival in stages I and II. Subgroups are discussed which bear a high risk of relapsing disease (big mediastinal masses, E-lesions of the lungs, histological findings with lymphocyte depletion).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01696208
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  • 6
    Electronic Resource
    Electronic Resource
    Adult hypophosphatasia without apparent skeletal disease: “odontohypophosphatasia“ in four heterozygote members of a family (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 371-376 
    Details
    ISSN: 1432-1440
    Keywords: Adult hypophosphatasia ; Phosphoethanolamine ; Alkaline phosphatase ; Fatty liver ; Caries
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty members of a family with adult hypophosphatasia were examined clinically and biochemically. Severe caries causing early loss of permanent teeth was the only clinical symptom which could be attributed to hypophosphatasia. None of them had a history of defective bone mineralization, rachitic skeletal alterations, and recurrent pseudofractures or fractures. An iliac crest bone biopsy of the proposita showed a normal finding corresponding to the age of the patient. Four family members in two subsequent generations were affected, thus suggesting an autosomal dominant inheritance. Their serum and leukocyte alkaline phosphatases were reduced. The phosphoethanolamine (PEA) excretion in the urine was increased to a level which suggests a heterozygote state. The serum alkaline phosphatase activity could be ascribed to the liver isoenzyme fraction. This was shown by polyacrylamide electrophoresis, by inhibition studies with organ-specific inhibitors, heat inactivation, inhibition by antibodies, and treatment with neuraminidase. The proposita had an unexplained, diffuse fatty infiltration of the liver. Thus, not only alterations of bone but also of liver metabolism in hypophosphatasia should be considered. The variety of adult hypophosphatasia described in this paper is characterized by the lack of severe bone abnormalities, the apparently autosomal dominant inheritance, and the reduction of bone and intestinal isoenzyme in the serum. Our study suggests that hypophosphatasia is a heterogenous disorder which includes both severe and clinically mild forms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716257
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  • 7
    Electronic Resource
    Electronic Resource
    Determination of phosphoethanolamine in urine or in the presence of high taurine concentrations
    Amsterdam : Elsevier
    Analytical Biochemistry 142 (1984), S. 511-514 
    Details
    ISSN: 0003-2697
    Keywords: 2-aminoethanolphosphate ; chromatographic determination ; lead-salt precipitation ; phosphoethanolamine ; taurine
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-2697(84)90497-4
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  • 8
    Electronic Resource
    Electronic Resource
    Anreicherung und eigenschaften von alkalischer phosphatase aus erythrocyten bei familiarer erythrocytose
    Amsterdam : Elsevier
    Clinica Chimica Acta 46 (1973), S. 363-370 
    Details
    ISSN: 0009-8981
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(73)90248-9
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  • 9
    Electronic Resource
    Electronic Resource
    Blastic phase chronic myeloid leukemia with a four-break rearrangement: t(11;9)(9;22)(q23;p22q34;q11)
    Amsterdam : Elsevier
    Cancer Genetics and Cytogenetics 68 (1993), S. 131-134 
    Details
    ISSN: 0165-4608
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-4608(93)90009-B
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  • 10
    Electronic Resource
    Electronic Resource
    The influence of the protease inhibitor aprotinin on tumor invasion of three cell linesin vitro (1988)
    Springer
    Clinical & experimental metastasis 6 (1988), S. 107-113 
    Details
    ISSN: 1573-7276
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The production of protease by malignant cells has been held responsible for invasion. The effect of aprotinin, a broad-spectrum protease inhibitor, on malignant invasion was examined histologically in organotypical cocultures of precultured embryonic chick heart fragments with two human melanoma cell lines and one virus-transformed fetal mouse carcass cell line. In the presence of 400 KIU/ml aprotinin, invasion was still permissive, while in the comparison with 0·1Μg/ml vincristine, a microtubule and directional motility inhibitor and a well-documented anti-invasive agent, invasion was completely stopped. Aprotinin remained stable in the culture medium so that the presence of invasion cannot be explained by low drug concentration. It is concluded that aprotinin-sensitive proteases are not implicated in invasionin vitro in the cell types investigated, and that thisin vitro technique deserves further interest for the study of protease inhibitors in the mechanism of invasion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01784841
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