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  • 1
    Electronic Resource
    Electronic Resource
    Auranofin and gold sodium thiomalate in the treatment of rheumatoid arthritis: A one-year, double-blind, comparative multicenter study (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 167-174 
    Details
    ISSN: 1432-1440
    Keywords: Auranofin ; Gold sodium thiomalate ; Rheumatoid arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a 48-week, double-blind trial, 122 patients were randomly assigned to treatment with auranofin (60) and gold sodium thiomalate (GST) (62) at five centers. Both groups showed significant improvement (P〈0.05) from baseline in parameters of disease activity. Results of the covariance analysis for all patients who completed the trial showed no significant differences (P〈0.05) in efficacy between the two groups. The proportions of patients showing 50% or greater improvement in tender joints, swollen joints, activity index, severity of pain, general health rating, and erythrocyte sedimentation rate (ESR) were similar for both auranofin-treated and GST-treated patients who completed the 48-week trial. When all patients who entered the trial were evaluated, a slightly greater proportion of patients on auranofin had improved. Diarrhea occurred more frequently with auranofin (32%) compared to GST (19%), whereas rash and pruritus were twice as common in those patients treated with GST compared to those treated with auranofin. The withdrawal rate due to adverse reactions was 10% for auranofin vs 26% for GST. It was concluded that the efficacy of auranofin was comparable to that of injectable gold and was better tolerated, as evidenced by the lower withdrawal rate from adverse events for the auranofin patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01727786
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  • 2
    Electronic Resource
    Electronic Resource
    A three year comparative multicenter study of auranofin (AF) and gold sodium thiomalate (GST) in the treatment of rheumatoid arthritis (RA) (1987)
    Springer
    Clinical rheumatology 6 (1987), S. 43-52 
    Details
    ISSN: 1434-9949
    Keywords: Auranofin ; Gold Treatment ; Disease Modifying Drugs ; Rheumatoid Arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02203384
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  • 3
    Electronic Resource
    Electronic Resource
    A three year comparative study of auranofin and gold sodium thiomalate in rheumatoid arthritis (1990)
    Springer
    Clinical rheumatology 9 (1990), S. 461-474 
    Details
    ISSN: 1434-9949
    Keywords: Auranofin ; Gold Sodium Thiomalate ; Rheumatoid Arthritis ; Treatment ; Long-term Treatment ; Gold Salts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary One hundred twenty-one patients with active RA were randomly assigned to receive 6 mg auranofin (AF)/day (60 patients) or 50 mg gold sodium thiomamate (GST)/week (62 patients) in a double-blind fashion. There were no intergroup differences with respect to sex, age, duration (median 2 years), stage and activity of the disease. In the case of “striking improvement” after 24 weeks a dose reduction to 50 mg GST/month or 4 mg AF/day was allowed and carried out in all GST patients and no AF patient. The serum gold levels were 5 times higher with weekly GST, they approached those of the AF group with monthly GST injections. The clinical parameters — number of swollen joints, activity index, articular index, grip strength, ESR — improved significantly in both groups, but grip strength, articular index and ESR improved more pronounced in the GST group. The X-ray progression (hands and forefeet) was significantly greater in the AF group. Fourthy eight AF patients (80%) and 39 GST patients (36%) completed the first year. Thereafter the study was continued as an open study but the patients were allowed to switch from GST to AF. After the first and second year 14/7 GST patients switched to AF. The second/third year was completed by 37/22 AF pat. (62%/37%) and by 15/8 GST pat. (24%/13%). Skin reactions were more common with GST (41.9%/26.7%), diarrhoea was more common with AF (36.7%/19.4%), proteinuria occurred in 10% in both groups, leucopenia and thrombocytopenia were rare in both groups (1.7%). The withdrawal rate due to adverse events was 10%/26% in the AF/GST group during the first year (p〈0.05) and 25%/32% over the three year period (n.s.). Conclusion Both AF and GST are effective in the long-term treatment of RA, but GST is more so in radiological progression and ESR.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02030507
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  • 4
    Electronic Resource
    Electronic Resource
    IX Eular Workshop for Rheumatology Research (1989)
    Springer
    Clinical rheumatology 8 (1989), S. 118-172 
    Details
    ISSN: 1434-9949
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02031083
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  • 5
    Electronic Resource
    Electronic Resource
    Beitrag zur Klinik und Diagnostik der Bronchusadenome, Bericht über 23 Fälle (1972)
    Springer
    Lung 148 (1972), S. 45-59 
    Details
    ISSN: 1432-1750
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Clinical experiences in 23 cases of bronchial adenoma, 15 men and 8 women, are reported. These patients were admitted to a pneumophtisiology department between 1949 and 1970. Twenty-two adenomas were carcinoid and one cylindromatous. In 12 cases the correct histological diagnosis was established preoperatively by bronchoscopy and biopsy. Eighteen tumours were central and 5 peripheral. Twenty-one patients presented because of symptoms existing for an average of 2,9 years, 2 patients were symptomless. Twenty patients underwent surgery and resection proved possible in 19 of these cases. Stress is laid on the importance of preoperative histological diagnosis for the indication and scope of resection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02096146
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  • 6
    Electronic Resource
    Electronic Resource
    Beitrag zur Klinik, Diagnostik und Therapie des Alveolarzellcarcinoms (1973)
    Springer
    Lung 148 (1973), S. 281-296 
    Details
    ISSN: 1432-1750
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über Erfahrungen bei 21 Alveolarzellcarcinomen der Lungen berichtet, die zwischen 1949 und 1972 an einer Lungenabteilung diagnostiziert werden konnten. Die Diagnose wurde 3mal durch Obduktion, 10mal durch Untersuchung des Resektionspräparates, 1mal durch Lingulabiopsie und 7mal durch Exfoliativcytologie gestellt. Bei 10 Pat. konnte eine Resektion durchgeführt werden: 5 blieben rezidivfrei, davon leben 3 Pat. 1, 8 und 13 Jahre; 2 verstarben 3 bzw. 8 Jahre postoperativ. Von den 11 nicht operierten leben nur noch 2 Pat. 4 bzw. 8 Monate nach der Diagnosestellung. Anhand einzelner Fallbeispiele werden verschiedene röntgenologische Erscheinungsbilder und Verlaufsformen geschildert und auf die Problematik der alleinigen cytologischen Diagnosestellung Alveolarzellcarcinom hingewiesen. Aufgrund von Literaturübersichten wird zur Häufigkeit unter den Bronchuscarcinomen, zur Geschlechts- und Altersverteilung, dem Nicotinkonsum und der Therapie Stellung genommen und Vergleiche zum Bronchuscarcinom angestellt.
    Notes: Abstract Experiences in 21 patients with alveolar cell carcinoma of the lung admitted to a pneumophthisiology department between 1949 and 1972 are reported. Diagnosis was established by autopsy in 3 cases, by histological examination of material from lung resection in 10 cases, by lingula biopsy in 1 case and by cytological studies in 7 cases. Resection proved possible in 10 cases; 5 of these patients have remained free of disease, 3 of whom are living after 1, 8 and 13 years while 2 of them died 3 and 8 years postoperatively. Of the other 11 patients only 2 are alive, 4 and 8 months after diagnosis. Individual case histories are used to illustrate different radiographic appearances and clinical courses of the disease, and the difficulty of establishing diagnosis by cytology only is discussed. Based on reviews of the literature, frequency among bronchogenic carcinoma, distribution by sex and age, smoking habits and therapy are discussed and compared to those for bronchogenic carcinoma. Finally stress is laid on the fact that diagnosis of alveolar cell carcinoma should be followed by the same measures as applied in other histological types of bronchogenic carcinoma. If possible every patient should be submitted to surgery without delay.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02148561
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