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  • 1
    Electronic Resource
    Electronic Resource
    Preparation and evaluation of 99mTc(V)-DMSA complex: Studies in medullary carcinoma of thyroid (1987)
    Springer
    European journal of nuclear medicine 12 (1987), S. 623-628 
    Details
    ISSN: 1619-7089
    Keywords: 99mTc(V)-DMSA ; Medullary carcinoma ; Tumour imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Consequent to the promising results reported with 99mTc(V)-DMSA for imaging certain types of soft tissue tumors, we have developed methods to prepare this radiopharmaceutical in three ways:-(i) from freshly prepared reagents, (ii) through the use of a two component kit and (iii) use of the standard renal DMSA kit by a modified recipe. The 99mTc(V)-DMSA complex has been subjected to paper electrophoretic and chromatographic procedures and also biodistribution studies. The distinctly different behaviour of this new product compared to that of the well known renal DMSA complex has been clearly established. Scintiimaging in a preliminary clinical trial in patients with medullary carcinoma of the thyroid has been encouraging.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284540
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Clinical evaluation of 99mTc(V)-dimercapto succinic acid (DMSA) for imaging medullary carcinoma of thyroid and its metastasis (1988)
    Springer
    European journal of nuclear medicine 13 (1988), S. 507-510 
    Details
    ISSN: 1619-7089
    Keywords: Medullary carcinoma ; 99mTc(V)-DMSA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 99mTc(V)-DMSA kits developed by the Radiopharmaceutical Division, Bhabha Atomic Research Centre, have been evaluated for potential use in scanning medullary carcinoma of the thyroid and its metastases. There were 15 patients with proved medullary carcinoma and 6 patients with other differentiated thyroid carcinoma. Amongst the 15 patients with medullary carcinoma, 12(80%) showed positive localisation either in the primary or one or more metastatic sites. None of the six patients with carcinoma other than medullary showed increased concentration of 99mTc (V)-DMSA. Of the 37 known metastatic sites in 15 patients with medullary carcinoma, 24 showed concentration of 99mTc (V)-DMSA (64.9%). In addition, 99mTc(V)-DMSA concentration was seen in 14 sites where no evidence of metastasis was revealed. The incidence of 99mTc (V)-DMSA concentration in soft tissue and bone metastasis was similar.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256625
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Gastroesophageal reflux scintigraphy with radioactive capsules — a new technique for detection and quantitation of reflux (1990)
    Springer
    European journal of nuclear medicine 16 (1990), S. 345-348 
    Details
    ISSN: 1619-7089
    Keywords: Gastroesophageal reflux ; Radioactive Capsule ; Physiological ; Non-invasive Quantitation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A new technique for performing quantitative gastroesophageal scintigraphy has been described. The method involves administration of radioactivity in capsule form into the stomach; the isotope is released after dissolution of the capsule. The mean time of onset of capsule breakage was 3.3 min (range 2–5 min) and complete dissolution occurred by 6.0 min (range 5–8 min). The appearance of isotope activity in the oesophagus by means of cine scintigraphy was quantified by PDP 11/34 computer (Gamma-11) in terms of percentage of gastroesophageal reflux (GER). In 15 healthy subjects, the percentage of reflux (mean ±S.D.) in the lower, middle and upper oesophagus was found to be 1.25±0.67, 0.26±0.23 and 0.02±0.04 respectively. We have studied 52 patients using this technique, and results are encouraging.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00842790
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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