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  • 1
    Electronic Resource
    Electronic Resource
    Comparison of the activity and plasma levels of oxprenolol, slow release oxprenolol, long acting propranolol and sotalol (1980)
    Springer
    European journal of clinical pharmacology 17 (1980), S. 419-424 
    Details
    ISSN: 1432-1041
    Keywords: oxprenolol ; propranolol ; sotalol ; slow release preparation ; plasma level ; exercise tachycardia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Observations were made in 5 healthy subjects who exercised before and 1, 3, 6, 8 and 24 h after the oral administration on separate occasions of 160 mg oxprenolol, 160 mg slow release oxprenolol, 160 mg long acting propranolol and 400 mg sotalol. Blood samples were obtained before and at 1, 2, 3, 6, 8, 10 and 24 h after drug administration and assayed for drug concentration. Although the plasma concentration of oxprenolol after S. R. oxprenolol was significantly less at 1 and 2 h and significantly greater at 24 h than after conventional oxprenolol, there was little difference between the effects of the two drugs on an exercise tachycardia. The plasma level of propranolol and the reduction in an exercise tachycardia after L. A. propranolol increased slowly to reach a peak at 6 h and then declined gradually to 24 h. The maximum plasma concentration and effect after sotalol occurred at 3 h and then declined with an elimination half-life of 12.1 h. At 24 h the percentage reduction in an exercise tachycardia was 8.3±2.5 after oxprenolol, 10.0±2.3 after S. R. oxprenolol, 18.0±3.2 after L. A. propranolol and 14.7±3.4% after sotalol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00570158
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of chronic captopril therapy on adrenergic receptors, plasma noradrenaline and the vascular responses to infused noradrenaline (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 229-235 
    Details
    ISSN: 1432-1041
    Keywords: noradrenaline ; captopril ; adrenergic receptors ; pressor response ; healthy volunteers ; reninangiotensin system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Adrenergic receptors (alpha2, beta2), plasma noradrenaline, heart rate and the pressor responsiveness to infused noradrenaline were examined in ten healthy male volunteers before and after 2 weeks of placebo or captopril therapy in a double blind cross-over study. No significant differences in these measurements were observed between the captopril and placebo treated groups. The study shows that in sodium replete normotensive subjects, long-term angiotensin converting enzyme inhibition does not lead to changes in adrenoceptor density. There is also no alteration in plasma noradrenaline levels nor in the pressor responsiveness to infused noradrenaline. These data suggest that the known interaction between the renin-angiotensin system and the sympathetic nervous system observed in animals is probably of little significance in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607568
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  • 3
    Electronic Resource
    Electronic Resource
    SOTALOL AS A HYPOTENSIVE AGENT IN PREGNANCY (1980)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 87 (1980), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Sotalol, a beta-adrenoceptor blocking drug, was administered to 12 hypertensive pregnant women. The concentration of the drug was assayed in samples of maternal plasma, amniotic fluid and mixed umbilical cord plasma at delivery and, in five mothers who elected to breast feed, in paired samples of maternal plasma and breast milk. Sotalol reduced blood pressure effectively at a mean daily dose of 433·1±54·1 mg but crossed the placental barrier. The mean maternal: fetal plasma concentration ratio was 1:1·05 and the mean amniotic fluid concentration was 7·0±2·7 μg/ml. Delivery occurred at mean gestational age of 37·7±0.7 weeks; 12 infants were liveborn with a mean weight of 2·8±0·1 kg and eight of them had no significant neonatal problems. Of the other four, two died from severe congenital anomalies, one had perinatal asphyxia and one mild transient hypoglycaemia. High sotalol concentrations were found in breast milk (mean plasma: milk ratio was 1:5·4) raising the possibility of pharmacological effect in the newborn infant. The results suggest that sotalol adequately controls blood pressure in hypertension complicating pregnancy but because, unlike results from the pregnant ewe, it crosses the human placental barrier it offers no apparent advantages over other beta-adrenoceptor antagonists.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1980.tb04618.x
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    Paper (German National Licenses)
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