ISSN:
1569-8041
Keywords:
11q22–q23 deletion
;
ataxia-telangiectasia
;
ATM
;
mantle-cell lymphoma
;
tumor suppressor gene
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Background:Mantle-cell lymphoma (MCL) is geneticallycharacterized by the translocation t(11;14)(q13;q32) leading to anoverexpression of cyclin-D1, but additional chromosomal abnormalities appearto be required for MCL pathogenesis. Patients and methods:Deletions involving chromosome 11q, whichwere recently found as recurrent aberrations in MCL, were analyzed at themolecular level in a series of 81 MCL by fluorescence in situhybridization (FISH) with probes from a contiguous set of yeastartificial chromosomes (YACs) spanning bands 11q14–q24. Results and conclusions:Loss of chromosome 11 material wasobserved in 37 of the 81 MCL cases (46%). The consensus deletioncomprised YAC 801e11 containing the ATMgene. The minimal region ofloss was further narrowed with P1–derived artificial chromosome (PAC) probes.This allowed the identification of a deletion confined to the genomic regionof ATM, which, together with intragenic mutations found in the codingsequence, suggests a role of ATMas a tumor suppressor gene in MCL.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008315003377
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