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  • 1
    Electronic Resource
    Electronic Resource
    Pulmonary angiography: a safe procedure with modern contrast media and technique (1998)
    Springer
    European radiology 8 (1998), S. 86-89 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Pulmonary embolism ; Angiography ; Safety
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Pulmonary angiography (PA) for decades has been accepted as the gold standard for the diagnosis of pulmonary embolism (PE). Apprehensions that the procedure is expensive, invasive and thus associated with both fatal and non-fatal complications has more or less limited its use to patients presenting a non-diagnostic lung scan. However, this opinion originates from earlier studies. Increasing clinical demands for faster and safer diagnostics, together with improved techniques and safer contrast media, has led to an increased use of PA. In order to evaluate the complication rate, we retrospectively studied the case records of 707 consecutive patients who had undergone PA. During 1990–1994, 728 patients underwent PA at Danderyd and Huddinge University Hospital. Selective pulmonary angiography (cine or digital subtraction angiography), non-ionic, low-osmolar contrast media and modern pigtail catheters were used. Standard volumes were 40 ml at 2 s for each injection. Pressure measurements were made in 376 patients. A test injection was made in all patients in order to assess the flow rate. Experienced radiologists as well as residents performed the examinations and a total of 707 angiography protocols and clinical records were available for review in search of complications associated with the procedure. No deaths occurred. One major non-fatal complication (bleeding in the groin requiring surgery) was reported in one case. Moderate/minor complications (i. e. transient angina and cardiac failure, minor haematomas, urticaria) occurred in 10 patients (1.4 %). With modern contrast media and technique, pulmonary angiography is a safe procedure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050344
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  • 2
    Electronic Resource
    Electronic Resource
    Validity of pulmonary cine arteriography for the diagnosis of pulmonary embolism (1999)
    Springer
    European radiology 9 (1999), S. 276-280 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Angiography ; Arteriography ; Pulmonary embolism ; Interobserver variations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The aim of this study was to assess the interobserver variations in diagnosis of pulmonary embolism (PE) with cine technique and to compare the diagnostic accuracy of pulmonary arteriograms to final-outcome diagnosis. One hundred and seventy patients with clinical suspicion of acute PE were examined with ECG, laboratory tests, chest X-ray, pulmonary scintigraphy and selective pulmonary cine arteriography. The follow-up time was 6 months. Fifty-one arteriograms were interpreted as positive for PE. Two pulmonary emboli were missed when compared with the diagnosis as stated by the final-outcome committee. No arteriograms were considered as not of diagnostic quality. Mean interobserver agreement in lobar vessels was 100 %, in segmental vessels 93 % and in subsegmental vessels 63 %. The mean interobserver agreement was 89 %. Pulmonary cine arteriography produces high diagnostic accuracy and few inconclusive results in patients with suspected PE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050667
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  • 3
    Electronic Resource
    Electronic Resource
    No volume effect on retrograde colonic spread of rectally-administered ropivacaine gel (2003)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 18 (2003), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Rectal administration of enemas, foams and suppositories is the most efficient way to deliver locally acting drugs to the distal colon. Ropivacaine, a long-acting local anaesthetic, was chosen as a candidate for a new rectal treatment of ulcerative colitis.Aim : To determine the colonic spread of a rectal ropivacaine formulation.Methods : In this randomized, incomplete cross-over study, 12 male volunteers were given 200 mg ropivacaine HCl rectally in 20, 40, 60 and 80 mL hydroxypropyl methylcellulose gel. The viscosity of the gel was 1.1 Pa s. The spread of the radiolabelled (99mTc-labelled diethylenetriaminepenta-acetic acid) formulations was assessed by gamma-scintigraphy. Plasma was collected and analysed for ropivacaine base.Results : The retrograde spread was limited to the descending colon and the difference between the studied volumes was not statistically significant. Only the 80-mL volume tended to have a larger distribution, although the 20-mL volume showed the same maximal distribution in two subjects. No distinct relationship between volume, retrograde colonic spread and plasma concentrations could be found. Ropivacaine was well tolerated.Conclusions : Rectal ropivacaine gel in all volumes between 20 and 80 mL can spread up to the descending colon. There was no relationship between either retrograde colonic spread or the administered volume and the ropivacaine plasma concentrations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2003.01741.x
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  • 4
    Electronic Resource
    Electronic Resource
    Dislocation of the elbow joint (1984)
    Springer
    Archives of orthopaedic and trauma surgery 102 (1984), S. 183-186 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei einem bis heute in der Literatur noch uneinheitlichen Therapiekonzept für Ellengelenksluxationen bzw. Luxationsfrakturen versuchen die Verfasser, ihr Vorgehen anhand von 89 Patienten darzulegen. Einfache Dislokationen wurden geschlossen reponiert und grundsätzlich für 2 bis 3 Wochen immobilisiert. Redislokationen wurden nicht beobachtet. Luxationen des Ellengelenkes, die mit einer größeren Absprengung des Processus coronoideus oder einer Fraktur des Radiusköpfchens einhergingen, wurden ausnahmslos operativ angegangen, da nach Auffassung der Autoren eine konservative Behandlung der Frakturen oft zu Reluxationen neigt. Zeigen die Nachkontrollen von insgesamt 72 Patienten für die einfachen Luxationen in 85% der Fälle gute bis sehr gute Behandlungsergebnisse, so resultieren bei den Luxationsfrakturen stets beachtliche Funktionseinbußen.
    Notes: Summary Although dislocation of the elbow is a common injury, it has been the subject of very few papers in the orthopaedic literature during the last 20 years. The recommendations for treatment have usually been conservative but in later years wider indications for surgical treatment with ligament repair have been recommended. Seventy-two patients with simple elbow dislocations (38) and fracture dislocations (34) treated at the departments of orthopaedic surgery in Göteborg 1975–1980 were reviewed. Results for patients with simple dislocations were excellent and good in 85 per cent and no difference could be recorded between those treated by surgery and those treated conservatively. Results after treatment of fracture-dislocations were generally worse and only 41 per cent achieved excellent or good results. We concluded that most simple dislocations should be treated conservatively with closed reduction followed by a short period of immobilization. In fracture-dislocations surgical repair of the elbow ligaments should be considered especially when the radial head has been excised.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00575230
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  • 5
    Electronic Resource
    Electronic Resource
    Instant technetium 99m hexamethyl propylenamine oxime-labeled leukocyte scan compared with colonoscopy in early assessment of disease extent and activity in acute colitis (1996)
    Springer
    Diseases of the colon & rectum 39 (1996), S. 1146-1152 
    Details
    ISSN: 1530-0358
    Keywords: Colonoscopy ; Crohn's disease ; Inflammation ; Leukocyte scanning ; Ulcerative colitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract AIM: This study was undertaken to evaluate technetium 99m (Tc 99m) hexamethyl propylenamine oxime (HMPAO)-labeled leukocyte scintigraphy for assessment of disease extent and activity in acute colitis. PATIENTS AND METHODS: Twenty-seven patients, hospitalized because of acute watery and/or bloody diarrhea, were investigated using both total colonoscopy and Tc 99m HMPAO-labeled leukocyte scintigraphy within 48 hours after admittance. RESULTS: Final diagnoses were ulcerative colitis in 14 patients, Crohn's disease in 7 patients, and infectious colitis in 6 patients. Using colonoscopy as the reference method, the maximum extent of colitis was correctly assessed by the leukocyte scan in 18 patients (67 percent), although rectal engagement was not visualized in 5 (19 percent). In six additional patients, there was almost complete agreement between the two methods. One other patient, with left-sided ulcerative colitis, was erroneously assessed as having total extent. Two other patients (one with Crohn's colitis and one with infectious colitis) had different segments incorrectly assessed. Sensitivity, specificity, and diagnostic accuracy of scintigraphy in detecting active inflammatory segments were 0.85, 0.83, and 0.85, respectively. Intensity of inflammatory activity assessed by the leukocyte scan correlated significantly with colonoscopic assessment (r=0.719;P 〈0.0001). CONCLUSION: Information regarding extent, localization, and disease activity in patients with acute colitis of inflammatory or infectious origin may be satisfactorily obtained using Tc 99m HMPAO-labeled leukocyte scanning. The noninvasive nature of the method makes it an attractive early alternative to other investigational procedures such as total colonoscopy or barium examination, particularly in cases with an established diagnosis of inflammatory bowel disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02081417
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  • 6
    Electronic Resource
    Electronic Resource
    The S11 and S13 self incompatibility alleles in Solanum chacoense Bitt. are remarkably similar (1994)
    Springer
    Plant molecular biology 24 (1994), S. 571-583 
    Details
    ISSN: 1573-5028
    Keywords: amino acid replacement ; new S alleles generation ; S allele specificity ; S phenotype
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A genomic clone of the S11 allele from the self-incompatibility locus (S locus) in Solanum chacoense Bitt. has been isolated by cross-hybridization to the S. chacoense S13 allele and sequenced. The sequence of the S11 allele contains all the features expected for S genes of the Solanaceae, and S11 expression, as assessed by northern blots and RNA-PCR, was similar to that of other S. chacoense S alleles. The S11 protein sequence shares 95% identity with the phenotypically distinct S13 protein of S. chacoense and is the gametophytic S allele with the highest similarity to an existing allele so far discovered. Only 10 amino acid changes differentiate the mature proteins from these two alleles, which sets a new lower limit to the number of changes that can produce an altered S allele specificity. The amino acid substitutions are not clustered, suggesting that an accumulation of random point mutations can generate S allele diversity. The S11 intron is unusual in that it could be translated in frame with the coding sequence, thus suggesting an additional mechanism for the generation of new S alleles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00023555
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