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  • 1
    Electronic Resource
    Electronic Resource
    Lissencephaly (1988)
    Springer
    European journal of pediatrics 147 (1988), S. 447-448 
    Details
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00496439
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Visual versus Auditory Memory Stimulation in Patients with Probable Alzheimer's Disease A PET Study with 18 FDG (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 777 (1996), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Notes: Patients with probable Alzheimer's disease were either stimulated with a continuous visual recognition task (n = 18) or with a continuous auditory recognition task during PET measurement with 18 FDG. The PET scanner was a Siemens CTI, ECAT EXACT with 5 mm transaxial and 6 mm axial resolution. The global stimulation effects were nearly identical in both groups and increased of 4.17 ± 8.14% in the auditory stimulated group and of 4.03 ± 11.78% in the visual stimulated group. Beyond regional stimulation effects in both groups a common cerebellar stimulation effect was measured. It is concluded that the cerebellar stimulation effect reflects a modality independent cognitive process and that the only small enhancement of global glucose metabolism indicates disturbed stimuli processes and finally explained the patient's failure in memory tasks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1996.tb34424.x
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  • 3
    Electronic Resource
    Electronic Resource
    Positron emission tomography in myotonic dystrophy
    Amsterdam : Elsevier
    Psychiatry Research 50 (1993), S. 93-99 
    Details
    ISSN: 0165-1781
    Keywords: Regional cerebral glucose metabolism ; aging ; fluorodeoxyglucose ; frontal cortex ; lentiform nucleus
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0165-1781(05)80004-6
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Positron emission tomography in myotonic dystrophy
    Amsterdam : Elsevier
    Psychiatry Research 50 (1993), S. 93-99 
    Details
    ISSN: 0165-1781
    Keywords: Regional cerebral glucose metabolism ; aging ; fluorodeoxyglucose ; frontal cortex ; lentiform nucleus
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0165-1781(05)80004-6
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Activation PET as an Instrument to Determine Therapeutic Efficacy in Alzheimer's Disease (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 695 (1993), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Notes: Forty patients with probable Alzheimer's disease (AD) were selected from a pool of 80 patients and assigned to 4 groups. Each received either social support, cognitive training only, or cognitive training in combination with pyritinol or phosphatidylserine. Treatment duration was 6 months. Before and after treatment the patients underwent neuropsychological testing as well as measurement of the regional cerebral metabolic rate for glucose using positron emission tomography (PET) and 2[18F]-fluoro-2-deoxy-D-glucose (FDG). Before treatment, the groups were comparable in respect to resting and activated glucose pattern achieved by a visual recognition task. They did not differ in scores of a neuropsychological test battery. After the treatment period the group with cognitive training + phosphatidylserine showed a significant glucose enhancement during the stimulation tasks in various brain regions, and an improvement in cognitive functioning compared to the other groups. The group with cognitive training + pyritinol had better stimulation effect as that of the social support group indicating that a combination of cognitive training + pharmacological intervention was superior than that of cognitive training alone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1993.tb23078.x
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  • 6
    Electronic Resource
    Electronic Resource
    Normal and pathological aging – findings of positron-emission-tomography (1998)
    Springer
    Journal of neural transmission 105 (1998), S. 821-837 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: Positron emission tomography ; brain ; aging ; premature aging ; dementia.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. Normal aging of the brain is predominantly characterized by metabolic changes in the prefrontal cortex. While in middle age there is a trend to hyperfrontality, PET demonstrates in old age a decline of regional cerebral glucose metabolism in frontal areas. In progeric diseases, clinically apparent as premature aging, the metabolic pattern is similar like in normal aging but qualitatively more severe. In patients with the diagnosis of probable Alzheimer's disease (AD) hypometabolism in early dementia is typically present in heteromodal association areas. Hypometabolism then spreads to other cortical and subcortical regions suggesting a characteristic pattern of degeneration that reflects selective vulnerability within limbic-cortical networks. Synaptic plasticity, clinically apparent as cognitive reserve capacity, can be assessed by PET under specific cognitive activation. In AD it is reduced in comparison to age-matched normals and may be influenced by drugs giving trophic support to neurochemical systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020050097
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  • 7
    Electronic Resource
    Electronic Resource
    In-vivo measurements of regional acetylcholine esterase activity in degenerative dementia: comparison with blood flow and glucose metabolism (2000)
    Springer
    Journal of neural transmission 107 (2000), S. 1457-1468 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: Dementia ; cholinergic system ; acetylcholine esterase ; positron emission tomography ; cerebral blood flow ; cerebral glucose metabolism.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. Memory and attention are cognitive functions that depend heavily on the cholinergic system. Local activity of acetylcholine esterase (AChE) is an indicator of its integrity. Using a recently developed tracer for positron emission tomography (PET), C-11-labeled N-methyl-4-piperidyl-acetate (C-11-MP4A), we measured regional AChE activity in 4 non-demented subjects, 4 patients with dementia of Alzheimer type (DAT) and 1 patient with senile dementia of Lewy body type (SDLT), and compared the findings with measurements of blood flow (CBF) and glucose metabolism (CMRGlc). Initial tracer extraction was closely related to CBF. AChE activity was reduced significantly in all brain regions in demented subjects, whereas reduction of CMRGlc and CBF was more limited to temporo-parietal association areas. AChE activity in SDLT was in the lower range of values in DAT. Our results indicate that, compared to non-demented controls, there is a global reduction of cortical AChE activity in dementia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020070009
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  • 8
    Electronic Resource
    Electronic Resource
    Mischtumoren der Pinealisregion Diagnostik und Therapie bei Vorliegen sezernierender Keimzelltumoranteile (1998)
    Springer
    Der Nervenarzt 69 (1998), S. 519-524 
    Details
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Pinealismischtumoren ; Sezernierende Keimzelltumoren ; β-HCG ; AFP ; Chemotherapie ; Key words Pinealoma ; Secreting germ cell tumors ; Primary intracranial germ cell tumors ; Tumor markers β-HCG and AFP ; Polychemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary
    Notes: Zusammenfassung
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001150050307
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  • 9
    Electronic Resource
    Electronic Resource
    Regional cerebral glucose metabolism and postmortem pathology in Alzheimer's disease (1996)
    Springer
    Acta neuropathologica 91 (1996), S. 174-179 
    Details
    ISSN: 1432-0533
    Keywords: Key words Alzheimer's disease ; Regional cerebral ; glucose metabolism ; Semiquantitative neuropathology ; Neurofibrillary tangles ; Senile plaques
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In four patients with an antemortem diagnosis of probable Alzheimer's disease (AD) regional cerebral glucose metabolism (rCMRGl) was studied prospectively by positron emission tomography (PET) and compared with postmortem semiquantitative neuropathology. The interval between the last PET study and autopsy was 1.3±0.8 years. In comparison with age-matched controls, the AD patients showed predominant temporoparietal hypometabolism spreading to other cortical and subcortical regions during serial PET scans. All patients had neuropathological findings typical for AD. There was a significant relationship between rCMRGl and density of senile plaques (SP) in one patient (τb = –0.86, P 〈 0.05). SP were distributed quite homogeneously in all regions examined. Neurofibrillary tangles (NFT) were concentrated focally in the hippocampus-amygdala-entorhinal complex. In the context of widespread developing cortical hypometabolism, the predilection of NFT for involvement in limbic areas suggests a disruption of projection neurons as the pathogenetic process of cortical dysfunction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050410
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  • 10
    Electronic Resource
    Electronic Resource
    Cognitive impairment in Alzheimer's disease correlates with ventricular width and atrophy-corrected cortical glucose metabolism (1995)
    Springer
    Neuroradiology 37 (1995), S. 270-277 
    Details
    ISSN: 1432-1920
    Keywords: Brain, MR ; Positron imaging ; Dementia ; Metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We compared the correlation of PET and MRI with neuropsychological tests in 26 patients with probable Alzheimer's disease (AD). The width of the temporal horns and the third ventricle, regional metabolic rates of glucose (rCMRGlu) and the proportion of cerebrospinal fluid space in mesial temporal and temporoparietal cortical regions were measured with three-dimensionally coregistered PET and MRI in two planes perpendicular to the Sylvian fissure. Highly significant correlations between rCMRGlu and neuropsychological tests were found mainly in the temporoparietal cortex, with and without correction for atrophy. Correlations of similar magnitude were seen also between most tests and the width of the temporal horns and third ventricle. Changes in the third ventricle and mesial temporal lobe were best seen with MRI, whereas PET most clearly depicted alterations in neocortical association areas. These two aspects of the disease correlated with the severity of dementia to a similar degree.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00588331
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