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  • 1
    Electronic Resource
    Electronic Resource
    Islet cell antibodies in normal French schoolchildren (1992)
    Springer
    Diabetologia 35 (1992), S. 577-582 
    Details
    ISSN: 1432-0428
    Keywords: Islet-cell antibodies ; prevalence rate ; HLA-DQ region ; Type 1 (insulin-dependent) diabetes mellitus ; children
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Islet-cell antibodies have been reported to be of predictive value for the future development of Type 1 (insulin-dependent) diabetes in first degree relatives of diabetic patients with the risk increasing in these subjects with the islet-cell antibodies titre. However, very little is known about islet-cell antibodies in background populations. Sera (n= 8363) from schoolchildren (6–17 years) in the French background population were screened for the presence of islet-cell antibodies by the indirect immunofluorescence technique. Islet-cell antibodies greater than 4.5 Juvenile Diabetes Foundation units were found in 150 sera (prevalence rate 1.8%; 95% confidence interval 1.5–2.1%). Only 17 sera demonstrated islet-cell antibody titre 〉-24 JDF units. No particular feature was found to be significantly different between islet-cell antibody-positive and islet-cell antibody-negative children (age, family history of diabetes, fasting plasma glucose, insulin autoantibodies). A second blood sample was obtained from 80 of 150 islet-cell antibody positive children after a mean interval of 8 months. Only 11 sera became 〈 4.5 JDF units with islet-cell antibody titres being stable in the remaining sera, including the high-titre positive sera (〉 24 JDF units). HLA-DQB typing was performed by restriction mapping techniques in 80 islet-cell antibody-positive, in 93 islet-cell antibody-negative and in 213 Type 1 diabetic children. The distribution of the susceptibility alleles (DQB1-Asp57-negative) was not significantly different between islet-cell antibody-positive and islet-cell antibody-negative children. This survey has identified a low islet-cell antibody prevalence rate in French schoolchildren, among whom the incidence rate of Type 1 diabetes is one of the lowest in Europe. The genetic study indicates that part of this group of children are not prone to developing the disease. The predictive value of islet-cell antibodies in normal children will be estimated during the long-term follow-up of this population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400487
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  • 2
    Electronic Resource
    Electronic Resource
    The Fourth International Workshop on the Standardisation of Insulin Autoantibody Measurement (1990)
    Springer
    Diabetologia 33 (1990), S. 638-639 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400213
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  • 3
    Electronic Resource
    Electronic Resource
    Enalapril does not alter renal function in normotensive, normoalbuminuric, hyperfiltering Type 1 (insulin-dependent) diabetic children (1989)
    Springer
    Diabetologia 32 (1989), S. 255-260 
    Details
    ISSN: 1432-0428
    Keywords: Angiotensin converting enzyme inhibition ; enalapril ; glomerular hyperfiltration ; diabetic nephropathy ; glomerular filtration rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using a prospective randomised double-blind crossover design, the effect of the angiotensin converting enzyme inhibitor enalapril compared to a placebo was studied in 18 normotensive, normoalbuminuric Type 1 (insulin-dependent) diabetic children. Each patient had a high normal or clearly elevated glomerular filtration rate (145 ml· min−1· 1.73 m2 or higher) in the 6 months prior to the study. Enalapril, 0.5 mg·kg−1· day−1, was given for 4 weeks followed by placebo for 4 weeks, or vice versa. At the end of each period, glomerular filtration rate, renal plasma flow, blood pressure, plasma renin activity, and converting enzyme activity were determined. Enalapril caused significant reduction (p=〈0.001) in blood pressure and converting enzyme activity and a rise in plasma renin activity. A slight but not significant rise in glomerular filtration rate and renal plasma flow without change in filtration fraction was observed. These data suggest that the renin angiotensin system is not involved in the glomerular hyperfiltration of Type 1 diabetes, and can be interpreted as showing no evidence for the presence of intraglomerular hypertension in these patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00285294
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  • 4
    Electronic Resource
    Electronic Resource
    Anti-37kDa antibodies are associated with the development of IDDM in individuals with islet cell antibodies (1995)
    Springer
    Diabetologia 38 (1995), S. 370-375 
    Details
    ISSN: 1432-0428
    Keywords: Key words Insulin-dependent diabetes ; islet cells antibodies ; anti-37kDa antibodies ; prediction ; specificity.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Antibodies directed against a beta-cell specific antigen with a molecular weight of 37 kDa have recently been described. These anti-37kDa antibodies were measured by the immunoprecipitation technique in individuals at risk for insulin-dependent diabetes mellitus (IDDM), with islet cell antibodies (ICA) greater than 20 Juvenile Diabetes Foundation units (JDFU). These subjects were recruited from large population-based cohorts at various degrees of risk for developing the disease before adulthood. Anti-37kDa antibodies were measured in 25 ICA-positive first degree relatives with ICA greater than 20 JDFU, identified from a baseline cohort of 1,185 relatives (age: 0–75 years). Four relatives were positive for anti-37kDa antibodies since the first determination onwards. These relatives developed IDDM in a 2-year follow-up period. We included 300 children with an IDDM parent, and aged less than 7 years, in a prospective survey for the prediction of IDDM. Five (1.6 %) showed ICA greater than 20 JDFU. None of them were found to be positive for anti-37kDa antibodies, and none have progressed to diabetes during a 2-year follow-up. Among a baseline cohort of 13,380 schoolchildren (age: 6–17 years), 28 (0.2 %) were found to have ICA greater than 20 JDFU. One boy was positive for anti-37kDa antibodies on two consecutive occasions and developed IDDM after a 10-month follow-up. No other schoolchildren with ICA greater than 20 JDFU were found to be positive for anti-37kDa antibodies. Altogether 40 other ICA-positive sera (with titres 〈 20 JDFU) were found to be negative for anti-37kDa antibodies. With our assay, anti-37kDa antibodies were found to have a 76 % sensitivity (95 %CI: 68–92 %) at the time of diagnosis in diabetic children. The current observations are based on a short-term follow-up. An analysis based on a longer period will be extremely useful for the prediction of IDDM and the appearance of anti-37kDa antibodies. [Diabetologia (1995) 38: 370–375]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400644
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Anti-37kDa antibodies are associated with the development of IDDM in individuals with islet cell antibodies (1995)
    Springer
    Diabetologia 38 (1995), S. 370-375 
    Details
    ISSN: 1432-0428
    Keywords: Insulin-dependent diabetes ; islet cells antibodies ; anti-37kDa antibodies ; prediction ; specificity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Antibodies directed against a beta-cell specific antigen with a molecular weight of 37 kDa have recently been described. These anti-37kDa antibodies were measured by the immunoprecipitation technique in individuals at risk for insulin-dependent diabetes mellitus (IDDM), with islet cell antibodies (ICA) greater than 20 Juvenile Diabetes Foundation units (JDFU). These subjects were recruited from large population-based cohorts at various degrees of risk for developing the disease before adulthood. Anti-37kDa antibodies were measured in 25 ICA-positive first degree relatives with ICA greater than 20 JDFU, identified from a baseline cohort of 1,185 relatives (age: 0–75 years). Four relatives were positive for anti-37kDa antibodies since the first determination onwards. These relatives developed IDDM in a 2-year follow-up period. We included 300 children with an IDDM parent, and aged less than 7 years, in a prospective survey for the prediction of IDDM. Five (1.6%) showed ICA greater than 20 JDFU. None of them were found to be positive for anti-37kDa antibodies, and none have progressed to diabetes during a 2-year follow-up. Among a baseline cohort of 13,380 schoolchildren (age: 6–17 years), 28 (0.2%) were found to have ICA greater than 20 JDFU. One boy was positive for anti-37kDa antibodies on two consecutive occasions and developed IDDM after a 10-month follow-up. No other schoolchildren with ICA greater than 20 JDFU were found to be positive for anti-37kDa antibodies. Altogether 40 other ICA-positive sera (with titres 〈20 JDFU) were found to be negative for anti-37kDa antibodies. With our assay, anti-37kDa antibodies were found to have a 76% sensitivity (95%CI: 68–92%) at the time of diagnosis in diabetic children. The current observations are based on a short-term follow-up. An analysis based on a longer period will be extremely useful for the prediction of IDDM and the appearance of anti-37kDa antibodies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400644
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Variation by age group and seasonality at diagnosis of childhood IDDM in Europe (1995)
    Springer
    Diabetologia 38 (1995), S. 823-830 
    Details
    ISSN: 1432-0428
    Keywords: Key words Childhood IDDM ; seasonability ; age of onset.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recent data provided by the EURODIAB ACE study group have confirmed wide variation in the incidence of insulin-dependent diabetes mellitus (IDDM) across Europe. The aim of this report is to compare age-specific incidence and seasonality at clinical onset of IDDM between study regions. Using a uniform methodology, the EURODIAB ACE framework ascertained 3,168 newly-diagnosed cases of IDDM in children under the age of 15 years during 1989–1990. Eighteen percent of the cases were age 0–4 years at diagnosis, 34 % were age 5–9 years and 48 % were age 10–14 years. Poisson regression analysis suggested that there were highly significant statistical differences in incidence between the three age groups and between the 24 regions. Although incidence rates in the 0–4 year and 5–9 year age groups varied from region to region in a similar fashion, the pattern of variation in the older age group was different. Seasonality of diagnosis conformed to a sinusoidal model with a peak occurring in winter, a feature which was consistently observed in both sexes and in all age groups. However, a statistically significant heterogeneity in the seasonal distribution was present among regions, those in Scandinavia showing the smallest relative amplitude. The first insulin injection was given the same day or the day after diagnosis in 93 % of the cases for whom data were available. [Diabetologia (1995) 38: 823–830]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050359
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Glial and neuronoglial malformative lesions associated with medically intractable epilepsy (1994)
    Springer
    Acta neuropathologica 87 (1994), S. 196-201 
    Details
    ISSN: 1432-0533
    Keywords: Key words: Hamartoma – Focal cortical dysplasia – Microdysgenesis – Epilepsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. In a large series of 116 cortical resections for treatment of medically intractable epilepsy, 10 glial hamartomas and 11 neuronoglial malformative lesions were found. Glial hamartomas were astrocytic in 3 cases, oligodendrocytic in 6 and mixed oligoastrocytic in 1. Neuronoglial lesions corresponded to "focal cortical dysplasia" in 6 patients and to "microdysgenesis" in 5 others. This study focuses on the various neuropathological presentations of these malformative epileptogenic lesions, and on correlations with neuro-imaging data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296190
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  • 8
    Electronic Resource
    Electronic Resource
    Glial and neuronoglial malformative lesions associated with medically intractable epilepsy (1994)
    Springer
    Acta neuropathologica 87 (1994), S. 196-201 
    Details
    ISSN: 1432-0533
    Keywords: Hamartoma ; Focal cortical dysplasia ; Microdysgenesis ; Epilepsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a large series of 116 cortical resections for treatment of medically intractable epilepsy, 10 glial hamartomas and 11 neuronoglial malformative lesions were found. Glial hamartomas were astrocytic in 3 cases, oligodendrocytic in 6 and mixed oligoastrocytic in 1. Neuronoglial lesions corresponded to “focal cortical dysplasia” in 6 patients and to “microdysgenesis” in 5 others. This study focuses on the various neuropathological presentations of these malformative epileptogenic lesions, and on correlations with neuro-imaging data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296190
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Long term feasibility of multiple daily injections with insulin pens in children and adolescents with diabetes (1989)
    Springer
    European journal of pediatrics 149 (1989), S. 80-83 
    Details
    ISSN: 1432-1076
    Keywords: Children with IDDM ; Multiple insulin injections ; Insulin injector pen ; Blood glucose control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract During a period of 17 months, 15 C-peptide negative insulin-dependent diabetic children (14±4 years old) have used an injector pen (Novopen, Novo, France) to deliver soluble insulin before meals, in association with an insulin syringe for long-acting insulin administration at bedtime. Despite frequent daily insulin injections (4–5) and blood glucose determinations (3–4), long-term patient acceptability as well as cutaneous tolerance were excellent. Novopen was experienced as a progress (100%) which made a multiple injection regimen acceptable and provided an improvement in the quality of life (77%), as recorded by questionnaires answered at the end of the study. Twelve out of 15 patients chose to continue this treatment. No significant change in glycaemic control was observed in the group as a whole. An improvement in glycosylated haemoglobin (HbA 1c) was noticed only in the previously “poorly-controlled” children (n=8) with initial HbA1c〉7%. In this group HbA1c decreased from 8.4±1.8% (mean±SD), to 7.3±1.2% (P〈0.05) within the first 6 months of Novopen therapy. No increment of hypoglycaemia frequency and mean daily insulin requirements was observed. No ketoacidotic episode was noticed during the study. In conclusion, in this group of diabetic children, no long term metabolic improvement was obtained, despite excellent acceptability of the multiple injection regimen with Novopen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01995851
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  • 10
    Electronic Resource
    Electronic Resource
    EFFECTS OF 2-AMINO-2-HYDROXYMETHYL-1,3-PROPANEDIOL ON ACID-BASE BALANCE DURING TEMPORARY THORACIC OCCLUSION OF THE INFERIOR VENA CAVA IN THE DOG (1961)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 92 (1961), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1961.tb45019.x
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