ISSN:
1432-0797
Source:
Springer Online Journal Archives 1860-2000
Topics:
Process Engineering, Biotechnology, Nutrition Technology
Notes:
Abstract A structured segregated model of budding yeast (Saccharomyces cerevisiae) populations is analysed in order to verify its ability to predict the spontaneous oscillations arising in continuous cultures. To obtain tractable and useful information about the relationships among the metabolic modifications during the cell cycle, the control over division and the occurrence of oscillations, very simple assumptions are considered and added to the model. The cell metabolism has been taken into account by assuming a diversification in the yield coefficient during the cell cycle. Moreover, in the oscillatory range, the cell mass is assumed to be constant at budding and to depend on the limiting substrate concentration at division. For a suitable range of parameter values, sustained oscillations are obtained, which can be compared to the experimental ones.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00369582
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