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  • 1
    Electronic Resource
    Electronic Resource
    Self-similar evolution of the nonlinear magnetic buoyancy instability (1990)
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 2 (1990), S. 1989-2000 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A new type of self-similar solution of ideal magnetohydrodynamics (MHD) in the nonlinear stage of the undular model (k(parallel)B) of the magnetic buoyancy instability (the ballooning instability in fusion plasma physics or the Parker instability in astrophysics) is found through MHD simulation and theory. The linear theory developed agrees well with our simulation in the early (linear) stage. The nonlinear stages of the instability in the simulation show the self-similar evolution. One of the solutions obtained from the nonlinear analysis has the characteristics of nonlinear instability in Lagrangian coordinates; the fluid velocity and the Alfvén speed on each magnetic loop increase exponentially with time, because the loop is evacuated by the field-aligned motion of matter resulting from gravitational acceleration. In the later stage of the nonlinear evolution, the solution property changes from exponential to power-law time dependence. The latter corresponds to a force-free expansion solution. The later saturation of the velocity increment is also discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.859420
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  • 2
    Electronic Resource
    Electronic Resource
    Conformational changes of aminoacyl-tRNA and unchanged tRNA upon complex formation with polypeptide chain elongation factor Tu
    Amsterdam : Elsevier
    FEBS Letters 263 (1990), S. 361-364 
    Details
    ISSN: 0014-5793
    Keywords: (Thermus thermophilus HB8) ; Aminoacyl-tRNA ; Circular dichroism ; Conformation change ; Elongation factor Tu
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(90)81414-J
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  • 3
    Electronic Resource
    Electronic Resource
    Molecular characterization of a 10-kDa buckwheat molecule reactive to allergic patients’ IgE (2004)
    Oxford, UK : Munksgaard International Publishers
    Allergy 59 (2004), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Using the sera from buckwheat (BW)-allergic patients, several putative causative molecules were reported. However, few molecules were determined on the molecular structure. We demonstrated in 2000 that the major allergen with 24 kDa (BW24KD) is a legumin-like storage protein.Objective:  The aim of this study was to isolate and characterize further a major allergen with 10 kDa by molecular cloning.Methods and results:  Buckwheat allergens were identified by immunoblotting analysis using sera from 14 allergic and two nonallergic individuals. We identified a protein with 10 kDa (BW10KD) that reacted with immunoglobulin E (IgE) more strongly than with IgG and IgA in 57% of the allergic patients but not with IgE in nonallergic individuals. Analyses were performed by N-terminal amino acid sequencing and molecular cloning. Physiological significance was assessed by an immunoblotting experiment showing that the reactivity of an allergic patient's serum IgE to BW10KD was competitively inhibited by natural BW extracts.Conclusion:  Molecular cloning experiments indicated that BW10KD as a BW allergen was a member of the 2S-albumin multigene family.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1398-9995.2003.00412.x
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  • 4
    Electronic Resource
    Electronic Resource
    Coherent motion of turbulent thermal plume in stably stratified fluid
    Amsterdam : Elsevier
    Fluid Dynamics Research 3 (1988), S. 415-421 
    Details
    ISSN: 0169-5983
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0169-5983(88)90102-5
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  • 5
    Electronic Resource
    Electronic Resource
    Natural convection in a vertical rectangular enclosure with localized heating and cooling zones (2000)
    Springer
    Heat and mass transfer 36 (2000), S. 467-472 
    Details
    ISSN: 1432-1181
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Experimental and numerical studies of natural convection in a single phase, closed thermosyphon were carried out using a vertical, rectangular enclosure model. Only one vertical plate plays the role of heat transfer surface having 100 mm height and 100 mm width, and others act as the adiabatic wall made of transparent plexi-glass. The heat transfer surface is separated into three horizontal zones with an equal height; top 1/3 and bottom 1/3 of the surface are cooling and heating zones, respectively and intermediate section is an adiabatic zone. Water is used as the working fluid. Variable parameters are distance D between the heat transfer surface and an adiabatic plate opposite to the heat transfer plate, and temperature difference ΔT between heating and cooling zones. By changing both D and ΔT, three regimes of the natural convection flow; quasi-two-dimensional steady, three-dimensional steady and unsteady flows are observed by means of thermo-sensitive liquid crystal powder and numerically simulated very well by solving a set of governing equations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002310000117
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  • 6
    Electronic Resource
    Electronic Resource
    Amplification of JC virus regulatory DNA sequences from cerebrospinal fluid: diagnostic value for progressive multifocal leukoencephalopathy (1998)
    Springer
    Archives of virology 143 (1998), S. 249-262 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary.  Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating disease in the central nervous system caused by a ubiquitous human polyomavirus designated as JC virus (JCV). PML affects individuals with decreased immune competence and is now one of the common opportunistic infections in patients with AIDS. JCV DNAs in the brain of PML patients contain various PML-type regulatory regions that were generated from the archetypal regulatory region during persistence. Recently, many studies have suggested that detection of JCV DNA from the cerebrospinal fluid (CSF) may offer a tool for diagnosing PML. However, in all of these studies, coding sequences within the T antigen or capsid protein gene have been targeted for amplification. To amplify the JCV regulatory region, we established a nested PCR that could efficiently amplify the regulatory region from most JCV subtypes prevalent in the world. Using this PCR, we amplified JCV regulatory regions from the CSF samples from 4 patients strongly suspected of PML, whereas amplification was negative from 80 CSF samples from patients without PML. Sequencing of the amplified fragments revealed that they had unique deletions and/or duplications. Furthermore, in 3 PML patients, we analyzed the structures of regulatory regions derived from the brain as well as CSF. In each of these cases, the major regulatory sequence of both origins were identical. This finding indicates that JCV DNA in brain lesions is excreted in the CSF. Since the structures of PML-type JCV regulatory regions are unique to individual patients, the current PCR, if the amplified fragments are sequenced, can eliminate false positives that may arise from contaminations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007050050284
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  • 7
    Electronic Resource
    Electronic Resource
    Peripheral neuropathy in late-onset Krabbe’s disease: histochemical and ultrastructural findings (1996)
    Springer
    Acta neuropathologica 92 (1996), S. 635-639 
    Details
    ISSN: 1432-0533
    Keywords: Key words Late-onset Krabbe’s disease ; Polyneuropathy ; Hypomyelination ;  Cytoplasmic ; inclusion body
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We performed histochemical and ultrastructural studies on a sural nerve biopsy specimen obtained from a 31-year-old man with late-onset Krabbe’s disease. Myelin sheaths were uniformly thin for the fiber diameter, with a moderate reduction in the myelinated fiber population. Despite a few small onion-bulb formations, quantitative studies demonstrated uniformly thin myelin sheaths and less variability in internodal lengths. This suggests that the main pathophysiology of the peripheral neuropathy observed in late-onset Krabbe’s disease is hypomyelination rather than segmental demyelination as in infantile Krabbe’s disease. Ultrastructurally, curvilinear lamellar cytoplasmic inclusions were observed in Schwann cells and fibroblasts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050573
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  • 8
    Electronic Resource
    Electronic Resource
    Cerebral perivenous calcification in neuropsychiatric lupus erythematosus: a case report (1998)
    Springer
    Neuroradiology 40 (1998), S. 583-586 
    Details
    ISSN: 1432-1920
    Keywords: Key words Brain ; Calcification ; perivenous ; Lupus erythematosus ; Computed tomography ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We present a case of neuropsychiatric lupus erythematosus with granular calcification in the basal ganglia and cerebral white matter on CT. Histopathologically, these were identified as perivenous necrotising lesions, with loss of axons and myelin sheaths and prominent dystrophic calcification.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050649
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  • 9
    Electronic Resource
    Electronic Resource
    Microinjection of sigma ligands into cranial nerve nuclei produces vacuous chewing in rats (1998)
    Springer
    Psychopharmacology 137 (1998), S. 191-200 
    Details
    ISSN: 1432-2072
    Keywords: Key words Sigma receptors ; DTG ; Haloperidol ; Dyskinesia ; Facial nucleus ; Spinal trigeminal nucleus ; Movement disorders
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Many typical neuroleptics carry a high risk for producing motor side effects in humans, and have significant affinities for sigma (σ) receptors. Sigma receptors are densely concentrated in cranial nerve nuclei that comprise the final common pathways for lingual, facial and masticatory movements; thus, they may serve as important substrates for some of the unwanted movements that can accompany neuroleptic treatment. Therefore, the purpose of this study was to evaluate whether microinjection of σ ligands into the facial nucleus or spinal trigeminal nucleus, oralis would cause orofacial dyskinesias, and whether these effects could be attenuated with σ receptor antagonists. Microinjection of the high affinity σ ligands, di-o-tolylguanidine or haloperidol (0–10 nmol/0.5 μl), produced a marked increase in vacuous chewing and facial tremors in rats, while coadministration of the functional σ antagonists, BD1047 or BD1063 (5 nmol), greatly attenuated these drug-induced movements. Sulpiride and clozapine (10 nmol/0.5 μl), σ inactive/ dopamine active atypical antipsychotic drugs with a much reduced risk for producing motor side effects in humans, were unable to elicit orofacial dyskinesias when microinjected into the facial or spinal trigeminal nucleus, oralis. These studies indicate that σ receptors may contribute to some forms of motor side effects resulting from antipsychotic drug treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050609
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  • 10
    Electronic Resource
    Electronic Resource
    Kiwifruits (Actinidia deliciosa) transformed with a Vitis stilbene synthase gene produce piceid (resveratrol-glucoside) (2000)
    Springer
    Plant cell reports 19 (2000), S. 904-910 
    Details
    ISSN: 1432-203X
    Keywords: Key words Kiwifruit ; Stilbene synthase ; Transformant ; Resveratrol ; Piceid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A stilbene synthase gene was isolated from three Vitis spp. (V. vinifera, V. labrusca and V. riparia). These genes were placed under the control of the cauliflower mosaic virus 35S promoter and introduced into kiwifruit (Actinidia deliciosa) plants by Agrobacterium-mediated gene transfer. The introduced gene(s) were expressed and piceid (resveratrol-glucoside) rather than resveratrol was produced in the leaves of the transformants. Resveratrol produced by the action of the integrated gene(s) seems to be metabolized into piceid by an endogenous glycosyltransferase. Among the transformants obtained, the highest piceid content in the young leaves was 182 μg/g fresh weight. Although these transformants did not show resistance against Botrytis cinerea, which causes gray-mould disease, the fruits may have some beneficial effects on human health.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002990000203
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