ISSN:
1573-2568
Keywords:
steroid hormones
;
partial hepatectomy
;
liver regeneration
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In five adult male patients undergoing a 40–60% partial hepatectomy, serum sex hormone levels before and after hepatic resection were determined. Blood was drawn immediately prior to each surgical procedure and at specified time points postoperatively. Compared to hormone levels found prior to surgery, following major hepatic resection, estradiol levels increase at 24 and 48 hr, while testosterone levels decline, being significantly reduced at 96 and 144 hr. These data demonstrate that adult males who undergo a 40–60% partial hepatectomy experience alterations in their sex hormone levels similar to those observed in male rats following a 70% hepatectomy. These changes in sex hormone levels have been associated in animals with an alteration of the sex hormone receptor status of the liver that is thought to participate in the initiation of the regenerative response. These studies suggest, but do not prove, that in man, as in the case of the rat, sex hormones may participate in the initiation of or at least modulate in part the regenerative response that occurs following a major hepatic resection.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01540264
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