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  • 1
    Electronic Resource
    Electronic Resource
    Stem cells : hype and hope (2000)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 406 (2000), S. 361-364 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Politicians, journalists, patients… it seems as though everyone is talking about stem cells. Why all the fuss? Stem cells have become the centre of so much attention because they turn into all the different cell types that make up complex organisms, and they promise to perform this ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35019186
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  • 2
    Electronic Resource
    Electronic Resource
    Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease (2002)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 418 (2002), S. 50-56 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Parkinson's disease is a widespread condition caused by the loss of midbrain neurons that synthesize the neurotransmitter dopamine. Cells derived from the fetal midbrain can modify the course of the disease, but they are an inadequate source of dopamine-synthesizing neurons because their ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature00900
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  • 3
    Electronic Resource
    Electronic Resource
    Dopaminergic neuronal differentiation from rat embryonic neural precursors by Nurr1 overexpression (2003)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 85 (2003), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In vitro expanded CNS precursors could provide a renewable source of dopamine (DA) neurons for cell therapy in Parkinson's disease. Functional DA neurons have been derived previously from early midbrain precursors. Here we demonstrate the ability of Nurr1, a nuclear orphan receptor essential for midbrain DA neuron development in vivo, to induce dopaminergic differentiation in naïve CNS precursors in vitro. Independent of gestational age or brain region of origin, Nurr1-induced precursors expressed dopaminergic markers and exhibited depolarization-evoked DA release in vitro. However, these cells were less mature and secreted lower levels of DA than those derived from mesencephalic precursors. Transplantation of Nurr1-induced DA neuron precursors resulted in limited survival and in vivo differentiation. No behavioral improvement in apomorphine-induced rotation scores was observed. These results demonstrate that Nurr1 induces dopaminergic features in naïve CNS precursors in vitro. However, additional factors will be required to achieve in vivo function and to unravel the full potential of neural precursors for cell therapy in Parkinson's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2003.01780.x
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  • 4
    Electronic Resource
    Electronic Resource
    Transplanted CNS stem cells form functional synapses in vivo (2000)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 12 (2000), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: An understanding of developmental mechanisms and new cell therapies can be achieved by transplantation into the nervous system. Multipotential stem cells have been isolated from the foetal and adult central nervous system (CNS). Immortalized and primary precursor cells integrate into the developing brain generating both neurons and glia as defined by immunological and morphological criteria. Here we show for the first time that in vitro-expanded CNS precursors, upon transplantation into the brains of rats, form electrically active and functionally connected neurons. These neurons exhibit spontaneous and evoked postsynaptic events and respond to focal glutamate application. Donor cells were grafted into the foetal hippocampus, and the amplitude and frequency of spontaneous synaptic events were monitored in the grafted cells in area CA1 for the first month of postnatal life. The formation of synapses onto grafted neurons indicates that grafted CNS stem cells can be used to study synaptic development in vivo and has important implications for clinical cell replacement therapies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9568.2000.00067.x
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  • 5
    Electronic Resource
    Electronic Resource
    Where Do Different Neurons Come From? (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 540 (1988), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Notes: The ability to make functionally competent brain precursor cell lines may have important consequences for a number of outstanding questions in mammalian CNS development. The diversity of neurons is one of the most striking conclusions of recent molecular studies of the nervous system. In our work we provided some of the earliest data to support this conclusion.30-32 Our preliminary data with precursor cell lines suggest that these cells give neurons with highly differentiated characteristics. If further work continues to support this conclusion, then immortal cell lines will be useful in analyzing the mechanisms that make neurons different. The methods that can be applied to these cell lines include manipulation in tissue culture, transplantation into the developing CNS, and application of the methods of mammalian cell genetics to link gene function to neuronal specificity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1988.tb27050.x
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  • 6
    Electronic Resource
    Electronic Resource
    A more astonishing hypothesis (2002)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 20 (2002), S. 426-427 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Two recent papers in Nature indicate that somatic stem cells can fuse with embryonic stem (ES) cells and that the hybrid cells retain the ability to differentiate toward many fates. Does cell fusion explain all the differentiation properties of somatic stem cells? I would argue that somatic stem ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0502-426
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  • 7
    Electronic Resource
    Electronic Resource
    Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 675-679 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Embryonic stem (ES) cells are clonal cell lines derived from the inner cell mass of the developing blastocyst that can proliferate extensively in vitro and are capable of adopting all the cell fates in a developing embryo. Clinical interest in the use of ES cells has been stimulated by studies ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/76536
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  • 8
    Electronic Resource
    Electronic Resource
    Mammalian deconstruction for stem cell reconstruction (2000)
    [s.l.] : Nature America Inc.
    Nature medicine 6 (2000), S. 747-748 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] EMBRYONIC STEM (ES) cells, derived from a clump of cells called the inner cell mass, are totipotent: they can be induced to differentiate into most of the cells of the body. These cells are now being studied for their ability to re-populate damaged tissue after stroke and spinal cord injury and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/77468
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  • 9
    Electronic Resource
    Electronic Resource
    Probing eukaryotic gene control (1979)
    [s.l.] : Nature Publishing Group
    Nature 282 (1979), S. 556-557 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] FOR two decades after the structure of double-stranded DNA had been determined, the difficulty of either establishing or manipulating a DNA sequence made even a descriptive approach to DNA-protein interaction difficult. The recent advances in DNA chemistry have been followed by improved methods of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/282556a0
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  • 10
    Electronic Resource
    Electronic Resource
    Movable genes (1980)
    [s.l.] : Nature Publishing Group
    Nature 287 (1980), S. 188-189 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] BARBARA McClintock's early studies on the breakage- fusion bridge cycle in maize served for many years as a reminder that a major class of genetic change was not explained by the central theories. This year's Cold Spring Harbor Symposium (May 28 - June 4, 1980) showed quite clearly that genetic ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/287188a0
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