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  • 1
    Electronic Resource
    Electronic Resource
    Photochemical donor pretreatment in clinical kidney transplantation —Preliminary report (1987)
    Springer
    Urological research 15 (1987), S. 211-213 
    Details
    ISSN: 1434-0879
    Keywords: Kidney transplantation ; Donor pretreatment ; PUVA ; Ultraviolet irradiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Extended experimental experience with the efficiacy of pretreating the kidney donor and the allograft by means of photochemotherapy (photosensitizer+UVA irradiation=PUVA) was adopted in clinical kidney transplantation. In a preliminary unrandomized study similar patient populations were treated by generally uniform methods. Thirty-three PUVA-pretreated kidneys (group A) were compared with the experience regarding 26 nonpretreated kidney allografts (group B). The number of rejection episodes was significantly lower in the first 3 months in group A (p〈 0.05 vs group B) and fewer grafts failed because of irreversible rejection (2 vs 5). Furthermore, in group A the rate of infectious complications was lower (18% vs 34%). The cumulative allograft survival at 3 months was improved from 65% in group B to 81% in group A and at 12 months from 65% 76%, respectively. These differences were not significant. Therefore, our preliminary clinical experience with a photochemical donor pretreatment is encouraging and further use in a randomized study seems to be necessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00262102
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  • 2
    Electronic Resource
    Electronic Resource
    Prolongation of rat renal allograft survival time by donor pretreatment with 8-methoxypsoralen and longwave ultraviolet irradiation of the graft (PUVA therapy) (1985)
    Springer
    Urological research 13 (1985), S. 95-98 
    Details
    ISSN: 1434-0879
    Keywords: PUVA ; Kidney transplantation ; Rat ; UV irradiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pretreatment of the kidney donor with 8-methoxypsoralen (8-MOP) and ex vivo longwave ultraviolet irradiation (UVA) of the kidney prolonged the subsequent survival on allogeneic recipients. The efficacy of this treatment seems to be dependent on the time and dose of UVA irradiation rather than on the dose of 8-MOP. In conclusion, PUVA treatment is effective in reducing the immunogenicity of the rat kidney allograft, although the mechanism remains unclear. These experimental findings are new and preliminary results in clinical human kidney transplantation are favourable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00261574
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  • 3
    Electronic Resource
    Electronic Resource
    Synergistic effect of donor pretreatment with 8-methoxypsoralen and ultraviolet irradiation of the graft plus azathioprine and prednisolone therapy in prolonging rat renal allograft survival (1986)
    Springer
    Urological research 14 (1986), S. 21-24 
    Details
    ISSN: 1434-0879
    Keywords: Kidney transplantatioon ; Rat ; PUVA therapy ; Ultraviolet irradiation ; Azathioprine ; Prednisolone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pretreatment of the kidney donor with 8-methoxy-psoralen (8-MOP) and direct longwave ultraviolet (UVA) irradiation of the kidney graft (PUVA therapy) significantly prolonged survival in allogeneic recipients. 40% of the recipients survived more than 100 days with normal transplant function. The addition of standard clinical immunosuppressive agents azathioprine and prednisolone (both at dosages of 15 mg/kg body weight/day for 21 days) to the PUVA therapy further improved graft survival rate, with a recipient survival rate of 62.5%. The two drugs alone were less effective in prolonging graft survival rate (28.5%). A synergistic effect of PUVA therapy and standard immunosuppressive treatment with azathioprine and prednisolone was demonstrated. This suggested a possible clinical application of this type of immunosuppression and immunoregulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00255528
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  • 4
    Electronic Resource
    Electronic Resource
    Fission probabilities of Cu, Nb, Ag, Ho, Au and Bi nuclei excited by stopped antiprotons (1995)
    Springer
    The European physical journal 352 (1995), S. 191-195 
    Details
    ISSN: 1434-601X
    Keywords: 25.85.W
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The A dependence of nuclear fission induced by stopped antiprotons has been measured. An unambiguous identification of the binary fission decay mode was provided by a coordinate measurement of complementary fission fragments in coincidence using a large-acceptance fission detector based on low pressure multiwire proportional chambers. A deep fissility minimum was observed nearA=100, in agreement with the general behaviour predicted by the liquid-drop model. An unexpectedly low and high fission probability was found for the Ag and Cu nuclei, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01298907
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  • 5
    Electronic Resource
    Electronic Resource
    The problem of ureter replacement (1970)
    Springer
    International urology and nephrology 2 (1970), S. 99-105 
    Details
    ISSN: 1573-2584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the light of the physiological-functional properties of the upper efferent urinary tracts and basing on our own animal experiments the question of bridging total ureteral defects is dealt with. For the time being, a successful ureter replacement over a longer period is only possible by endogenous, peristalting tissue that is sufficiently supplied with blood.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02125811
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  • 6
    Electronic Resource
    Electronic Resource
    The use of pediatric cadaver kidneys in renal transplantation (Experience with 97 cases and comparison with adult kidneys) (1981)
    Springer
    International urology and nephrology 13 (1981), S. 95-104 
    Details
    ISSN: 1573-2584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pediatric cadaver donors are an important pool of kidneys for human allotransplantation. Experiences with 97 transplantations of pediatric cadaveric kidneys (age: 4 months to 15 years) and comparison with 230 transplantations of adult kidneys (age: 16–25 and 40–68 years) are presented. The cumulative patient survival was similar in both groups, however, the graft survival was significantly lower in the pediatric donor group (p〈0.05). This difference was established almost exclusively within the first 3 months after transplantation. In this group the percentage of technical complications in the first month was higher (13.4%) than in the adult kidney group (6.5%). The analysis of the whole pool of harvested kidneys shows a significantly higher rate of transplanted kidneys in the pediatric group (61%) as compared with the adult group (44.7%). In both groups the mode of arterial vascular anastomosis (end-to-end or end-to-side) does not influence the graft survival. Further investigations on pediatric donor kidneys are necessary. The utilization of pediatric cadaveric kidneys for transplantation should be increased because 20–25% of all potential kidney donors are younger than 15 years.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02082078
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