Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1432-1440
    Keywords: Beta-adrenergic receptor blockers ; Blood pressure ; Diuretics ; Exercise ; Hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 34 men with essential hypertension the increase in blood pressure during static and dynamic exercise, after long-term antihypertensive medication, was investigated in a randomized prospective study. The patients were randomized to either hydrochlorothiazide or to atenolol. The exercise tests were performed after a mean treatment duration of 14 months. At this time, the entering blood pressure was significantly and equally lowered from 163/108 to 148/96 mm Hg with a mean dose of 71 mg hydrochlorothiazide and from 164/108 to 147/91 mm Hg with a mean dose of 144 mg atenolol. The heart rate was significantly lower under beta-blocker therapy (62 min−1) than with diuretics (78 min−1). There were no significant differences in the systolic and diastolic blood pressure rise between the two therapy groups duringstatic exercise with the hand grip (33% of the earlier determined individual maximum for 2 min duration) and with the squatting technique (for 2 min). Duringdynamic exercise on the bicycle ergometer (50–100 W) the increase in the systolic blood pressure was significantly lower between 70 and 100 W, with a range from 12 to 28 mm Hg, in the beta-blocker group than in the diuretic group. There were no differences in diastolic blood pressure between the two therapy groups. Rate-pressure product as a parameter for the myocardial oxygen consumption and heart rate were significant lower in the beta-blocker group as compared with the diuretic group, at rest and during both kinds of exercise and at all exercise steps. The lower increase in systolic blood pressure, during dynamic exercise as well as the lower ratepressure product at rest and during all kinds of exercise, in the beta-blocker group can influence, the selection of an antihypertensive, other factors taken into consideration.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 65 (1987), S. 1160-1163 
    ISSN: 1432-1440
    Keywords: Diuretic induced edema ; Idiopathic edema
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Both women with diuretic induced edema and with idiopathic edema present a typical history leading to the diagnosis in most cases. These women are almost exclusively in the reproductive age and they tend to have some other characteristics in common additionally. There is controversy whether idiopathic edema exists as a syndrom with multifactorial pathogenesis or if fluid retention in these women is due to diuretic abuse. In either case the use of diuretics is not indicated as they can increase and perpetuate the edema and moreover may bring about impairment of renal function. Abstinence of diuretic intake is the only way out of the vicious circle of fluid retention induced by intermittent diuretic intake resulting in intermittent edema and prostrained use of diuretics. Therapy of idiopathic edema is difficult; it includes physical therapy, psychotherapy and pharmacotherapy with aldosterone antagonists or ACE-inhibitors in some severe cases.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 63 (1985), S. 775-780 
    ISSN: 1432-1440
    Keywords: Digitalis therapy ; Prescription ; Serum concentration ; Withdrawal trial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The frequency of therapy with digitalis glycosides was determined in 4.143 patients on their first visit at a medical outpatient clinic. 508 (12.3%) patients said to take digitalis. Of 480 (94.5%) patients, a digoxin serum concentration was obtained. It was in 229 (47.7%) patients below, in 31 (6.5%) above, and in 220 (45.8%) within the therapeutic range (0.8–2.0 ng/ml). From the 251 patients with a serum digoxin concentration ≧0.8 ng/ml, 220 (87.7%) were not included in a withdrawal trial on the basis of predetermined criteria, mainly because of cardiac diseases (52%). Digitalis therapy was withdrawn in 31 patients. 5 patients started to take the drug again on their own; they were considered drop-outs. In the remaining 26 patients, no symptoms of heart failure appeared during a 3-month observation period; in 2 patients, however, atrial fibrillation requiring intervention occurred. Our results confirm the frequent use of digitalis therapy in Germany, but also the frequent presence of subtherapeutic serum digoxin concentrations. Withdrawal should be considered in patients with a questionable indication for this therapy; the occasional occurrence of supraventricular arrhythmias, and not so much of heart failure, should be anticipated.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 58 (1980), S. 1105-1115 
    ISSN: 1432-1440
    Keywords: Renovascular hypertension ; Excretory urography ; Bolustechnique ; Angiotomography ; Percutaneous transluminal angioplasty ; Catheterdilatation ; Renovaskuläre Hypertonie ; Ausscheidungsurographie ; Bolustechnik ; Angiotomographie ; Perkutane transluminale Angioplastik ; Katheterdilatation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Katheterdilatation (perkutane transluminale Angioplastik=PTA) von Nierenarterienstenosen ist mit Erfolg auch bei Patienten mit hohem Operationsrisiko ohne große Gefährdung durchführbar. Deshalb muß die Indikation zur Diagnostik von Nierenarterienstenosen auf alle Patienten mit Verdacht auf renovaskuläre Hypertonie ausgedehnt werden. Das Ausscheidungsurogramm mit Angiotomographie mit der Möglichkeit der morphologischen Darstellung der Nierenarterien bietet sich dazu an. Im 1. Teil werden die Ergebnisse dieser Methode dargelegt. Bei 415 Patienten wurde die Bolusinjektion des Kontrastmittels bisher ohne nennenswerte Nebenwirkungen durchgeführt. Es konnten 49 Nierenarterienstenosen, 1 Nierenarterienaneurysma und 1 AV-Fistel dargestellt werden. Bei 91 Patienten wurden Katheterangiographie, herkömmliches Frühserienurogramm und Angiotomographie verglichen. Die Angiotomographie erreichte bei der Diagnostik von Nierenarterienstenosen eine Sensitivität von 93% und eine Spezifität von 99%. Im 2. Teil werden die Ergebnisse der PTA von Nierenarterienstenosen bei 35 Patienten beschrieben. Sie war bei 29 Patienten (83%) technisch erfolgreich durchführbar. Über 3 klinisch stumm verlaufende Komplikationen wird berichtet. Bei einer mittleren Nachbeobachtungszeit von 8,2 Monaten war der Blutdruck bei 13 Patienten (45%) normalisiert und bei 10 (34%) gebessert. Die bei 11 Patienten vorhandene Niereninsuffizienz konnte 7 × normalisiert werden. Diese Ergebnisse machen die PTA zur Behandlungsmethode der 1. Wahl bei renovaskulärem Hochdruck. Nur wenn diese Methode nicht anwendbar ist oder sich als technisch nicht durchführbar erweist, gilt die herkömmliche Alternative: chirurgische Revaskularisation — konservative medikamentöse Therapie.
    Notes: Summary Catheter-dilatation (Percutaneous Transluminal Angioplasty=PTA) of renal artery stenoses can be applied successfully and without major risk even in patients with high operative risks. Therefore, the indication for the diagnostic evaluation of renal artery stenosis should be expanded to all patients suspected to have renovascular hypertension. Excretory urography combined with angiotomography offers the possibility to visualize the renal arteries and to either detect or exclude arterial stenosis. In the first part results of this procedure are presented. The bolus injections have been carried out on 415 patients without any serious side-effects. Using angiotomography 49 renal artery stenoses, 1 aneurysm and 1 AV fistula could be detected. Catheterangiograms, angiotomograms and conventional rapid sequence urograms were compared in 91 patients. For angiotomography a sensitivity for the presence of renal artery stenosis of 93% and a specifity for the absence of arterial stenosis of 99% can be attained. In the second part, the results of PTA of renal artery stenoses in 35 patients are described. PTA was technically successful in 29 patients (83%). Three clinically silent complications are reported. In a mean follow-up period of 8,2 months, hypertension was normalized in 13 (45%) and improved in 10 (34%) patients. Renal insufficiency could be normalized in 7 out of 11 patients. These results make PTA the method of choice in treating renovascular hypertension. Only if this method is not applicable or technically not feasible, is the alternative for treatment surgical revascularization or conservative antihypertensive therapy.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 66 (1988), S. 322-322 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 64 (1986), S. 1211-1211 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1432-1440
    Keywords: Waldenström's macroglobulinemia ; Paraproteinemia ; Cryoglobulinemia ; Skin ulcers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 71-year-old man presented with epistaxis and large ulcers on arms and legs. A monoclonal IgM-kappa gammopathy and high levels of cryoglobulins were found. Histology of the affected skin showed deposits of paraprotein in the small vessels, causing luminal obstruction. This in turn caused ischemic skin lesions, which were successfully treated with cortisone (fluocortolone 100 mg/day every second day) and cyclophosphamide (100 mg/day).
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Chemistry and Physics of Lipids 59 (1991), S. 207-213 
    ISSN: 0009-3084
    Keywords: acetylhydrolase ; low density lipoproteins ; monocytes ; paf antagonists ; paf-acether receptors ; protein kinase C
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 92 (1978), S. 315-326 
    ISSN: 1432-1335
    Keywords: Nephroblastoma and neuroblastoma ; Statistical significance of histological features for prognosis ; Nephroblastom und Neuroblastom ; histologischer Differenzierungsgrad ; Überlebenschancen.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die statistische Auswertung der Prognose bei Nephroblastomen und Neuroblastomen ergibt eine höhere Überlebenschance, nicht nur für die Patienten mit früheren Tumorstadien, sondern auch für Tumoren mit höherem Differenzierungsgrad. Der wichtigste Parameter bei der histologischen Gradeinteilung von Nephroblastomen ist die tubuläre Differenzierung der Tumorzellen. Bei den Neuroblastomen richtet sich die Gradeinteilung nach der Ausreifung der Tumorzellen zu Ganglienzellen; parallel dazu nimmt auch das Neuropil zu. Nur bei den Neuroblastomen finden sich bei Patienten im frühen klinischen Tumorstadium auch häufiger Tumoren mit histologischen Differenzierungszeichen als undifferenzierte Tumoren. Eine kombinierte Aufschlüsselung der Nephroblastome und Neuroblastome nach klinischen Stadien und nach histologischer Gradeinteilung ergibt bei beiden für die 5-Jahres-Überlebenschance innerhalb der 4 resultierenden Gruppen 3 Gruppen mit unterschiedlichen Überlebenschancen. Diese 3 Risiko-Gruppen können auch als unterschiedliche therapeutische Zielgruppen eine Rolle spielen.
    Notes: Summary Statistically evaluating the influence of a histological grading, respectively of morphological differences on prognosis of nephroblastomas and neuroblastomas, better chances for survival become evident not only for earlier clinical stages, but also for nephroblastomas with high differentiation, or neuroblastomas with signs for differentiation. Only for neuroblastomas a relevant predeliction of tumors with signs of differentiation for the early clinical stage I is present. Combined subclassification according to clinical stages and histological grades results in 3 risk groups with different chances for survival. These 3 groups may play a role for specific therapeutic considerations.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 245 (1989), S. 244-247 
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Schwangerschaftshochdruck ist durch eine gesteigerte vaskuläre Reaktivität gekennzeichnet. In Parallelität zur essentiellen Hypertonie könnte man annehmen, daß hier ebenfalls ein Anstieg der beta-2-Adrenozeptor Dichte eine Rolle spielen könnte. Der Lymphozyt ist ein gutes Modell, um dieses System zu untersuchen. Dadurch würde sich eine Lücke in der Pathogenese der Schwangerschaftshypertonie schließen lassen.
    Notes: Summary During the last 10 years, radioligand binding studies have greatly advanced our knowledge about adrenoceptors in circulating lymphocytes. In essential hypertension the activity of the sympathetic system seems to be altered. Stimulation of the sympathetic system leads to rapid increase of lymphocyte beta-2-adrenoceptor density. In contrast, gestational hypertension is characterized by a decrease in cardiac output and enhanced arteriolar and venolar resistance. Peripheral resistance is modulated by alpha-and beta adrenoceptors and further studies are needed to characterize and quantify adrenoceptor density in gestational hypertension.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...