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  • 1
    Electronic Resource
    Electronic Resource
    Effects of an N-methyl-d-aspartate receptor agonist and its antagonist CPP on the levels of dopamine and serotonin metabolites in rat striatum collected in vivo by using a brain dialysis technique (1989)
    Springer
    Neurochemical research 14 (1989), S. 1075-1080 
    Details
    ISSN: 1573-6903
    Keywords: Dopamine ; serotonin ; NMDA receptor ; brain dialysis ; DOPAC ; HVA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 3-((±)-2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) is an antagonist at the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor. In the present study, levels of dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindolacetic acid (5-HIAA) were measured after intracerebroventricular injection of NMDA, CPP or both in rat striatum using a brain dialysis method. The injection of NMDA produced a significant increase in DOPAC level. HVA level was also increased by NMDA injection. The level of 5-HIAA was not affected by NMDA injection. The injection of CPP had no effect on DOPAC, HVA and 5-HIAA levels. The injection of CPP restrained the increase of DOPAC and HVA levels induced by NMDA injection. The results suggest that intracerebral injection of NMDA may increase dopamine release from rat striatum, but have no effect on serotonin release. Furthermore, CPP inhibits NMDA induced release of dopamine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00965613
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of chronic bifemelane hydrochloride administration on receptors for N-methyl-d-aspartate in the aged-rat brain (1992)
    Springer
    Neurochemical research 17 (1992), S. 687-691 
    Details
    ISSN: 1573-6903
    Keywords: NMDA receptors ; bifemelane hydrochloride ; aged-rat brain ; autoradiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We assayed N-methyl-d-aspartate (NMDA) receptors [3H]3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid ([3H]CPP) bindings) and evaluated their distribution in the brain by quantitative autoradiography in young adult and aged rats. In the young adult rats, NMDA receptors were present at relatively high concentrations in the cerebral cortex and hippocampus. In the aged rats, NMDA receptors were decreased in the nealy all areas of the brain, especially in the cerebral cortex and hippocampus. Chronic administration of bifemelane hydrochloride, a drug for sequela of cerebrovascular diseased, at a dose of 15 mg/kg/day for 14 days, markedly attenuated these decrease in NMDA receptors. Since NMDA receptors are considered to be involved in memory and learning processes, our results suggest that bifemelane hydrochloride may be applicable to the treatment of disturbed memory and learning.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00968006
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Changes of phorbol ester binding sites in rat brain following intracerebroventricular administration of thyrotropin-releasing hormone (TRH): An in vitro macroautoradiographic investigation (1992)
    Springer
    Neurochemical research 17 (1992), S. 361-365 
    Details
    ISSN: 1573-6903
    Keywords: TRH ; phorbol ester ; protein kinase C ; in vitro macroautoradiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined the influence of the intracerebroventricular (icv) administration of thyrotropin-releasing hormone (THH) on protein kinase C (PKC) activities in various rat forebrain regions in order to cast light on the mechanism of extra-pituitary non-endocrine physiological actions of TRH in the central nervous system. An in vitro macroautoradiographic method, with [3H]phorbol 12, 13-dibutyrate (PDBu) as the radioactive ligand, was used to investigate quantitative alterations of PKC activities. The optical densities for PDBu binding sites in the striatum and hippocampal formation were significantly increased after the icv administration of TRH, while those in the frontal cortex and septum were unchanged. These findings suggest that TRH may exert some of its non-endocrine functions through striatal and hippocampal neurons which used PKC in their second messenger systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00974578
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Nitroglycerin relieves emotional stress-induced stomach ulcers in rats (1994)
    Springer
    International journal of stress management 1 (1994), S. 299-307 
    Details
    ISSN: 1573-3424
    Keywords: stress ; ulcers ; nitroglycerin (GTN) ; nitric oxide (NO)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Psychology
    Notes: Abstract It is known that nitroglycerin (GTN) can be converted to form a nitric oxide (NO) molecule which is a highly reactive and unstable free radical species. NO is known to have many beneficial effects such as relaxing blood vessels, promoting digestive activity, and regulating blood pressure. The first experiment established an additional effect of NO, that GTN can help prevent emotionally-induced stomach stress ulcers in rats. In Experiment 2, we sought to estimate the quantity of nitrogen oxides in serum produced by GTN that is administered subcutaneously to rats. The results indicated that rats administered GTN increased significantly the amount of serum NO2 and NO3, relative to values for a control group. Since amounts of NO2 and NO3 reflect amount of NO, the administration of GTN significantly increased amount of NO. An implication of this research is that chemicals such as GTN may be used in therapy with humans for the prevention of some kinds of ulcers. Furthermore, while NO is commonly recognized as a pollutant, it has a number of beneficial effects on the body, e. g., it may slow the aging process, contribute to therapy for improtency, and facilitate memory processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01857998
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Ultrastructural changes in granule cell somata and mossy fibers of the rat hippocampus during picrotoxin-induced convulsions (1989)
    Springer
    Cell & tissue research 255 (1989), S. 261-267 
    Details
    ISSN: 1432-0878
    Keywords: Hippocampus ; Mossy fibers ; Picrotoxin ; Ultrastructure ; Rat (Wistar)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Ultrastructural changes in hippocampal granule cells, mossy fibers and mossy fiber boutons were examined following the administration of picrotoxin in adult rats. Generalized seizures occurred within 5–10 min after the intraperitoneal injection of picrotoxin. The electron-microscopic examination of hippocampal tissues from rats that had been perfused with fixative during the seizure revealed that the large dense-core vesicles increased in number and accumulated on the presynaptic membranes of mossy fiber boutons; some of these vesicles appeared to be fused with the membranes, and omega-shaped exocytotic profiles were frequently seen. Furthermore, greatly increased numbers of coated vesicles (60–90 nm in diameter) were observed on the maturing faces of Golgi fields of granule cells. Thus, our study not only indicates an increased incidence of exocytosis of large dense-core vesicles during picrotoxin-induced seizures, but also suggests that these vesicles are replaced in excess from the perikaryon of the granule cell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00224107
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    Paper (German National Licenses)
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