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  • 1
    Electronic Resource
    Electronic Resource
    Histochemische und autoradiographische Untersuchungen der Hippocampusformation der Maus (1966)
    Springer
    Histochemistry and cell biology 6 (1966), S. 267-273 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Mit Hilfe der Timmschen Sulfid-Silber-Methode und der Autoradiographie von Zn65 wird die Lokalisation von Zink in der Hippocampusformation bei Mäusen untersucht und diskutiert. Die wichtigsten Ergebnisse sind, daß 1. in den Gehirnen aller untersuchten Mäuse stets die gleichen cytoarchtektonischen Rindenfelder, d.h. Felder h3, h4, h5 und Gyrus dentatus mit der Sulfid-Silber-Methode stark positiv reagieren; 2. organisches radioaktives Zn56 innerhalb von 18–24 Std nach der Injektion in den Feldern h3, h4, h5 des Hippocampus und im Gyrus dentatus hochkonzentriert angereichert wird.
    Notes: Summary The localization of Zn in the hippocampus formation in mice is investigated by means of the sulphide-silver method (Timm) and autoradiography (Zn65). The most important results are: 1. In all mouse brains tested strongly positive results (silver-sulphide method) are obtained in the cortical areas, i.e. field h3, h4, h5 and Gyrus dentatus. 2. High concentrations of radioactive Zn65 are found within 18–24 hours p.i. in the h3, h4, h5 areas of the hippocampus and in the Gyrus dentatus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01257324
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  • 2
    Electronic Resource
    Electronic Resource
    Über die Veränderungen des Zinkgehaltes in der Hippocampusformation der Ratte nach Dithizon-, Alloxan und Oxinzufuhr (1968)
    Springer
    Histochemistry and cell biology 12 (1968), S. 357-362 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Mit Hilfe der Sulfid-Silbermethode wurde die Lokalisation von Zink in der Hippocampusformation von Ratten und ihre Veränderungen nach Dithizon-, Alloxan-und Oxinzufuhr untersucht. 1. Im normalen Zustand reagieren bestimmte Schichten in den Feldern h 3, h 4 und h 5 des Hippocampus und dem Gyrus dentatus stark positiv. 2. In den ersten 3 Std nach der Dithizongabe bleibt die Hippocampusformation vollkommen ungefärbt. Nach 4 Std wird die Reaktion wieder in den früheren, normalen Zustand zurückversetzt. 3. In den ersten 3 Std nach der Gabe von Alloxan und den ersten 2–3 Std nach der Gabe von Oxin wird die Hippocampusformation im Gegensatz hierzu stärker angefärbt. 3 1/2 Std nach der Alloxan- oder Oxingabe wird die Intensität der Reaktion in der Hippocampusormation in den früheren Zustand zurückversetzt. 4. Der Wirkungsmechanismus von Dithizon, Alloxan und Oxin auf das Nervengewebe der Hippocampusformation wird diskutiert.
    Notes: Summary Using the method of sulfide silver the distribution of zink in the hippocampal formation of rats was investigated. The investigation was extended to include changes in the distribution pattern after administration of Dithizon, Alloxan and Oxin. 1. Under normal conditions certain layers in field h 3, h 4 and h 5 of the hippocampal formation gave a strongly positive reaction. 2. During the first three hours following the administration of Dithizon the hippocampal formation remains unstained. After four hours, however, the reaction becomes as positive as normal reaction. 3. During the first three hours following the administration of Alloxan and the first 2–3 hours after the administration of Oxin the hippocampus formation stains more intensely. Three and a half hours after the administration of Alloxan or Oxin the intensity of the reaction in the hippocampus formation is that of a normal control. 4. The mechanism of the action of Dithizon, Alloxan and Oxin on the nervous tissue of the hippocampal formation is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00278309
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  • 3
    Electronic Resource
    Electronic Resource
    Changes of phorbol ester binding sites in rat brain following intracerebroventricular administration of thyrotropin-releasing hormone (TRH): An in vitro macroautoradiographic investigation (1992)
    Springer
    Neurochemical research 17 (1992), S. 361-365 
    Details
    ISSN: 1573-6903
    Keywords: TRH ; phorbol ester ; protein kinase C ; in vitro macroautoradiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined the influence of the intracerebroventricular (icv) administration of thyrotropin-releasing hormone (THH) on protein kinase C (PKC) activities in various rat forebrain regions in order to cast light on the mechanism of extra-pituitary non-endocrine physiological actions of TRH in the central nervous system. An in vitro macroautoradiographic method, with [3H]phorbol 12, 13-dibutyrate (PDBu) as the radioactive ligand, was used to investigate quantitative alterations of PKC activities. The optical densities for PDBu binding sites in the striatum and hippocampal formation were significantly increased after the icv administration of TRH, while those in the frontal cortex and septum were unchanged. These findings suggest that TRH may exert some of its non-endocrine functions through striatal and hippocampal neurons which used PKC in their second messenger systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00974578
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Ultrastructural changes in granule cell somata and mossy fibers of the rat hippocampus during picrotoxin-induced convulsions (1989)
    Springer
    Cell & tissue research 255 (1989), S. 261-267 
    Details
    ISSN: 1432-0878
    Keywords: Hippocampus ; Mossy fibers ; Picrotoxin ; Ultrastructure ; Rat (Wistar)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Ultrastructural changes in hippocampal granule cells, mossy fibers and mossy fiber boutons were examined following the administration of picrotoxin in adult rats. Generalized seizures occurred within 5–10 min after the intraperitoneal injection of picrotoxin. The electron-microscopic examination of hippocampal tissues from rats that had been perfused with fixative during the seizure revealed that the large dense-core vesicles increased in number and accumulated on the presynaptic membranes of mossy fiber boutons; some of these vesicles appeared to be fused with the membranes, and omega-shaped exocytotic profiles were frequently seen. Furthermore, greatly increased numbers of coated vesicles (60–90 nm in diameter) were observed on the maturing faces of Golgi fields of granule cells. Thus, our study not only indicates an increased incidence of exocytosis of large dense-core vesicles during picrotoxin-induced seizures, but also suggests that these vesicles are replaced in excess from the perikaryon of the granule cell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00224107
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    Paper (German National Licenses)
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