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  • 1
    Electronic Resource
    Electronic Resource
    Erythrocytosis in pseudohypoparathyroidism type I (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 341-342 
    Details
    ISSN: 1432-1440
    Keywords: Erythrocytosis ; Pseudohypoparathyroidism ; Erythropoietin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252824
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  • 2
    Electronic Resource
    Electronic Resource
    The time course of renal function and bone turnover in parathyroid crisis due to intratumoral hemorrhage (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 448-450 
    Details
    ISSN: 1432-1440
    Keywords: Parathyroid ; Crisis ; Kidney ; Bone ; Turnover
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Parathyroid crisis occurring in primary hyperparathyroidism is characteized by extremely high circulating levels of parathyroid hormone and acute onset of severe hypercalcemia. We describe a 62-year-old woman with parathyroid crisis probably due to an intraturnoral hemorrhage. Renal dysfunction reduced the effectiveness of preoperative management and continued to deteriorate for 5 days after parathyroidectomy. The normalization of serum calcium after parathyroidectomy delayed and it took 6 days. Maintenance of renal function is important for pre- and postoperative courses of the present case. The rapid decrease in serum parathyroid hormone after parathyroidectomy was followed by a rapid and transient (about fivefold) increase in serum alkaline phosphatase with peak value on the 10th postoperative day. This indicated that reversal phase from bone resorption (accelerated by parathyroid hormone) to bone formation lasted about 10 days under the conditions of the present case.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180519
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The modulatory effect of endogenous parathyroid hormone on the action of hydrochlorothiazide in pseudohypoparathyroidism type I (1994)
    Springer
    Calcified tissue international 54 (1994), S. 473-476 
    Details
    ISSN: 1432-0827
    Keywords: Pseudohypoparathyroidism ; Thiazide ; Kidney ; Bone ; Parathyroid hormone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract We compared the effect of orally administered 100 mg of hydrochlorothiazide (HCTZ) among eight patients with pseudohypoparathyroidism (PHP) type I, 11 patients with idiopathic hypoparathyroidism (IHP), and 12 patients with primary hyperparathyroidism (1oHPT). Patients with PHP type I or with IHP were studied during the treatment with 1α-hydroxylated metabolites of vitamin D3. HCTZ raised serum levels of calcium (Ca) in 1oHPT (P〈0.001) and PHP type I (P〈0.01) but did not increase urinary excretion of Ca. Serum parathyroid hormone (PTH) in PHP type I decreased (P〈0.02) after HCTZ administration in response to the increase in serum Ca. HCTZ did not raise serum levels of Ca in IHP but increased urinary excretion of Ca in this group (P〈0.01). HCTZ suppressed tubular reabsorption of phosphate (P) in IHP (P〈0.01) and 1oHPT (P〈0.05) but not in PHP type I. Urinary excretion of cAMP did not change after HCTZ administration in PHP type I, IHP, or 1oHPT. Endogenous PTH modulated the effects of HCTZ on Ca mobilization from bone and renal reabsorption of Ca in PHP type I with normal or high serum levels of PTH and in 1oHPT with high serum levels of PTH. The inhibitory effect of HCTZ on renal tubular reabsorption of P (probably from proximal tubules) was independent of PTH. The resistance to this inhibitory effect of HCTZ on P reabsorption in PHP type I suggested a proximal tubular dysfunction in this disorder.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334326
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  • 4
    Electronic Resource
    Electronic Resource
    Sigmoidal Curve Shift in Idiopathic Hypoparathyroidism and Pseudohypoparathyroidism (1998)
    Springer
    Calcified tissue international 62 (1998), S. 290-294 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Parathyroid hormone — Hypoparathyroidism — Pseudohypoparathyroidism — Secretion.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. The sigmoidal curves plotting serum parathyroid hormone (PTH) against serum Ca in primary hyperparathyroidism and secondary hyperparathyroidism due to renal failure deviate to the right. We previously found the leftward curve shift in PTH-deficient hypoparathyroidism. In the present study, we investigated the curve shift in pseudohypoparathyroidism (PHP) with secondary hyperparathyroidism due to target organ resistance to PTH. In renal failure the sigmoidal curves move to the left after vitamin D3 treatment. We also examined the effect of vitamin D3 on the curve shift in pseudohypoparathyroidism (PHP) and idiopathic hypoparathyroidism (IHP). Before vitamin D3 treatment, the sigmoidal curve deviated to the left in both types of hypoparathyroidism. After vitamin D3 treatment it moved to the right. These results indicate that vitamin D3 and/or extracellular Ca modify the relationship between PTH and Ca dynamics even in hypoparathyroid disorders with decreased or increased maximum serum PTH. Following vitamin D3 treatment, the point plotting baseline serum PTH against baseline serum Ca moved to the right at first in accordance with the rightward shift of the sigmoidal curve and then the point moved downward in PHP or downward in IHP. These changes suggest that vitamin D3 resets PTH secretion at a higher extracellular Ca level at first and then suppresses it in a time-dependent manner. 1,25(OH)2D3 and/or extracellular Ca may be the determinant factors of the sigmoidal curve shift in hypoparathyroid disorders. Mechanisms other than the Ca sensing system error may contribute to the curve shift.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900433
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  • 5
    Electronic Resource
    Electronic Resource
    The effect of endogenous parathyroid hormone, exogenous calcitonin, and dibutyryl cyclic AMP on urinary excretion of N-acetyl-β-D-glucosaminidase (1994)
    Springer
    Calcified tissue international 54 (1994), S. 186-194 
    Details
    ISSN: 1432-0827
    Keywords: Glucosaminidase ; Parathyroid hormone ; Calcnonin ; Cyclic AMP ; Urine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract Urinary excretion of N-acetyl-β-D-glucosaminidase (NAG) transiently increases after PTH(1–34) infusion in idiopathic hypoparathyroidism (IHP) but this response is impaired in pseudohypoparathyroidism (PHP) type I. We investigated the effects of endogenous PTH, exogenous calcitonin (CT), and dibutyryl cAMP (DBcAMP) on urinary excretion of NAG. Urinary NAG excretion in 14 patients with primary hyperparathyroidism (1oHPT) was more than in normal subjects (P〈0.001) and decreased after parathyroidectomy (P〈0.01). Urinary NAG excretion increased after the infusion of 1.5 MRC/kg of eel CT in eight normal subjects (P〈0.001), two patients with IHP, and a patient with PHP type Ib but not in a patient with PHP type Ia. The increases of urinary NAG excretion by CT and by PTH(1–34) were positively correlated with the increases of urinary cAMP excretion (r=0.752; P〈0.001 and r=0.534; P〈0.002, respectively). Urinary NAG excretion increased after DBcAMP infusion in five normal subjects (P〈0.01), two patients with IHP, and two with PHP type I. The increase of urinary NAG by 6.0 mg/kg of DBcAMP was more than by 2.5 mg/kg of DBcAMP in normal subjects (P〈0.01). The increase of urinary NAG by 2.5 mg/kg of DBcAMP in PHP type I was comparable with that by 6.0 mg/kg in normal subjects, suggesting a hyperresponsiveness to DBcAMP in PHP type I. Urinary excretion of NAG is a useful indicator of renal tubular responsiveness to PTH and CT. Cyclic AMP-dependent mechanism is probably involved in PTH and CT-induced increase in urinary excretion of NAG.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00301676
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  • 6
    Electronic Resource
    Electronic Resource
    Ratio of Baseline Level/Maximum Level of Serum PTH in Pseudohypoparathyroidism and Primary Hyperparathyroidism (1998)
    Springer
    Calcified tissue international 62 (1998), S. 99-103 
    Details
    ISSN: 1432-0827
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. The ratio of baseline level/maximum level of serum parathyroid hormone (PTH) is high in PTH-deficient hypoparathyroidism and it decreases after vitamin D3 treatment. There is a reversed sigmoidal relationship between the ratio and baseline serum Ca level. In this study, we further investigated the value of this ratio as a parameter of Ca-dependent changes of serum PTH in hyperparathyroid subjects. As in PTH-deficient hypoparathyroidism, the ratio in pseudohypoparathyroidism was high before vitamin D3 treatment and it decreased after 1,25(OH)2D3 treatment. The increased ratio may reflect the stimulated baseline PTH secretion from parathyroid cells perceiving the decrease in baseline extracellular Ca level. The points plotting the ratio against baseline serum Ca level were on the regression curve deduced from the data in PTH-deficient hypoparathyroidism. This result indicates that the relationship between the ratio and the baseline extracellular Ca level is unrelated to the variation in maximum secretion. The sigmoidal changes of serum PTH in patients with parathyroid adenoma were classified as follows. The first was with the upward and rightward curve shift, the second was only with the rightward curve shift, and the third was with the rightward curve shift, the increased minimum serum PTH, and the increased baseline/maximum ratio of serum PTH. These findings suggest that the decreased suppressibility of PTH secretion and the stimulated baseline secretion may develop without the increase in maximum secretion in some cases with parathyroid adenoma. In conclusion, the ratio of baseline level/maximum level of serum PTH may unfold a new aspect of secretion abnormality of parathyroid glands in several forms of parathyroid disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900401
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  • 7
    Electronic Resource
    Electronic Resource
    Relationship between Ca-Dependent Change of Serum PTHand Extracellular Ca2+-Sensing Receptor Expression in Parathyroid Adenoma (1999)
    Springer
    Calcified tissue international 64 (1999), S. 271-272 
    Details
    ISSN: 1432-0827
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abnormal PTH secretion and cell growth in hyperparathyroid tissues are accompanied with reduced expression of Ca2+-sensing receptor (CaR) which plays a key role in Ca-regulated PTH release. In this study, we examined the receptor expression in parathyroid adenomas using specific anti-CaR antibody and investigated relationship between CaR expression in adenomatous tissues and parameters of Ca-dependent change of serum PTH. The results show a considerable variation in the number of CaR positive cells among the adenomatous tissues. Expression of the receptor protein was not related to set-point error but was more reduced in the patients with more elevated minimum or baseline levels of serum PTH. CaR expression was severely reduced in the patients with highly elevated maximum serum PTH, while the receptor expression was also decreased in some patients with normal maximum serum PTH. Baseline level / maximum level ratio of serum PTH was increased in these patients. In conclusion, reduced CaR expression is related to abnormality in three parameters of PTH secretion (minimum serum PTH, maximum serum PTH, and baseline level / maximum level ratio of serum PTH) and may contribute to hypersecretion from parathyroid adenomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900617
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  • 8
    Electronic Resource
    Electronic Resource
    Resetting of parathyroid hormone secretion after vitamin D3 treatment in hypoparathyroidism and after parathyroid adenectomy in primary hyperparathyroidism (1995)
    Springer
    Calcified tissue international 57 (1995), S. 30-34 
    Details
    ISSN: 1432-0827
    Keywords: Parathyroid hormone ; Hypoparathyroidism ; Vitamin D3 ; Hyperparathyroidism ; Parathyroidectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract The relationship between parathyroid hormone (PTH) secretion and extracellular calcium (Ca) level is reciprocal causality. The equilibrium operating point determines basal PTH secretion rate and basal extracellular Ca level. We studied how this equilibrium was achieved in the subjects with decreased PTH secretion or decreased parathyroid glands number. Basal/maximum ratio of serum PTH, which reflects the basal secretory state of parathyroid glands, was increased in 9 hypoparathyroid patients treated with vitamin D3 (VD3) [7 patients with idiopathic hypopar-athyroidism (IHP), and two patients with postsurgical hypoparathyroidism] and in seven of nine parathyroid adenectomized patients. There was a negative correlation between the ratio and basal serum Ca level in the patients with IHP after VD3 treatment (r=0.7167, P〈0.05) and in the patients after parathyroid adenectomy (r=0.7760, P〈0.05). The regression curves in these two groups coincided regardless of the difference in maximum PTH secretion rate, which suggested that the basal secretory state of parathyroid glands was determined by extracellular Ca level in a similar manner in these subjects. There was a sigmoidal relationship between basal/maximum ratio of serum PTH and basal serum Ca level, when the data were collected from 15 hypoparathyroid patients before or after VD3 treatment, 9 parathyroid adenectomized patients, and 10 normal subjects (r=0.9057, P〈0.001). This sigmoidal curve is thought to represent the fundamental relationship between the basal secretory state of parathyroid glands and extracellular Ca level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00298993
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