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  • 1
    Digitale Medien
    Digitale Medien
    Stellar Populations in the Galaxy (1982)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Astronomy and Astrophysics 20 (1982), S. 91-115 
    Details
    ISSN: 0066-4146
    Quelle: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Thema: Physik
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1146/annurev.aa.20.090182.000515
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  • 2
    Digitale Medien
    Digitale Medien
    A Supernova at z = 0.458 and Cosmology (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 688 (1993), S. 0 
    Details
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1749-6632.1993.tb43936.x
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  • 3
    Digitale Medien
    Digitale Medien
    A phase II study of ifosfamide in endometrial cancer (1990)
    Springer
    Cancer chemotherapy and pharmacology 26 (1990), S. S4 
    Details
    ISSN: 1432-0843
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Around 32% of all patients with endometrial carcinoma relapse after primary therapy. The outlook for these patients is poor. Ifosfamide (IFX) has activity in a number of gynaecological malignancies and was selected for evaluation in this disease. The aims of this study were to assess the activity and toxicity of IFX in recurrent endometrial carcinoma no longer amenable to radical local treatment. In all, 16 evaluable patients with symptomatic advanced metastatic or recurrent disease entered a phase II study of this drug. Patients received IFX (5 g/m2) as a 24-h infusion, with mesna (8 g/m2) given during and for 12 h following IFX to prevent urothelial toxicity. Treatment was repeated every 21 days. Two patients showed evidence of response [one complete response (CR) of 3 months and one partial response (PR) lasting 5 months]. Most patients experienced nausea and vomiting, and WHO grade 3/4 alopecia invariably occurred after two or more cycles. Four patients developed severe (grade 3/4) IFX/mesna CNS toxicity, and four other patients had mild (grade 1/2) CNS toxicity. Significant myelosuppression was seen in 3/41 cycles. Haematuria was uncommon and invariably mild. There were two toxic deaths (one due to grade 4 CNS toxicity and one due to septicaemia). IFX has activity in endometrial carcinoma, but responses are of limited duration and toxicity is considerable.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00685407
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  • 4
    Digitale Medien
    Digitale Medien
    Phase II studies of ifosfamide alone and in combination in cancer of the cervix (1990)
    Springer
    Cancer chemotherapy and pharmacology 26 (1990), S. S12 
    Details
    ISSN: 1432-0843
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A series of phase II studies using ifosfamide (IFX) as a single agent and in combination with cisplatin and bleomycin (BIP) in advanced and recurrent cervical cancer have been coordinated at the West Midlands CRC Clinical Trials Unit (Birmingham, UK). The aims of these studies were to identify single agents and combination regimens that may be of value for palliation and have potential for use as neoadjuvant and adjuvant therapy at the time of primary treatment. A total of 79 patients with disease non-amenable to radical local therapy were treated with single-agent IFX or the BIP combination. In 30 patients treated with single-agent IFX, 10 objective responses (30%) were seen, with 1 complete response. In 49 patients treated with BIP, 34 objective responses (69%) were seen, with 10 complete responses (20%). Toxicity included alopecia, nausea and vomiting, myelosuppression, infection, reduction in renal function and disturbance of consciousness. These data indicate that IFX is highly active in cervix cancer and, in combination with bleomycin and cisplatin, can be used for effective palliation and cytoreduction in 〉70% of patients. IFX-containing regimens have potential for use as neoadjuvant and adjuvant therapy in patients at high risk of recurrence with conventional treatment. These hypotheses are currently being tested in prospective randomised trials.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00685409
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  • 5
    Digitale Medien
    Digitale Medien
    Tidal disruption of the Magellanic Clouds by the Milky Way (1998)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 394 (1998), S. 752-754 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Interactions between galaxies are common, and influence physical properties such as the global morphology and star-formation rate (Hubble type). Galaxies can interact in many different ways: they can merge together; they can pass through each other, with gas being stripped from the smaller of ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/29466
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  • 6
    Digitale Medien
    Digitale Medien
    Neoadjuvant bleomycin, ifosfamide and cisplatin in cervical cancer (1990)
    Springer
    Cancer chemotherapy and pharmacology 26 (1990), S. S59 
    Details
    ISSN: 1432-0843
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Patients with advanced and bulky early-stage cancer of the cervix have an unfavourable prognosis, which may be improved by initial neoadjuvant, cytoreductive chemotherapy. In a phase II study, coordinated at the West Midlands CRC Clinical Trials Unit, Birmingham, using ifosfamide (IFX) in combination with cisplatin and bleomycin (BIP) in advanced and recurrent cervical cancer, we demonstrated a response rate of 69%. This regimen produces rapid responses with acceptable toxicity and has potential for use as neoadjuvant therapy prior to radical radiotherapy in patients presenting with advanced and bulky early-stage disease. In an initial pilot study of this approach, 13 of 19 patients (68%) with primary inoperable disease showed significant tumour regression prior to radical local radiotherapy. Interim analysis of the first 66 patients entered into a randomized study evaluating the value of this approach has shown complete clinical tumour resolution after radical radiotherapy in 24/32 patients (75%) treated with up to three cycles of BIP prior to radiotherapy vs 19/34 patients (56%) treated with radiotherapy alone. There was no evidence that neoadjuvant chemotherapy enhances the acute toxic effects of pelvic radiotherapy. This approach has the potential for improving the outlook in patients with poor-prognosis primary disease.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00685422
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  • 7
    Digitale Medien
    Digitale Medien
    Placental transfer of chlorthalidone and its elimination in maternal milk (1978)
    Springer
    European journal of clinical pharmacology 13 (1978), S. 129-131 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Chlorthalidone (Hygroton) ; placental transfer ; carbonic anhydrase binding ; distribution in blood ; elimination in milk
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary A gas chromatographic method has been used to determine chlorthalidone in amniotic fluid, maternal and foetal blood at delivery, and in maternal milk and blood three days after delivery, following the administration of chlorthalidone to nine pregnant women suffering from toxaemia of pregnancy. Placental transfer of chlorthalidone and elimination in maternal milk have been shown and the implications of these factors are discussed. An explanation has been proposed for our observations that foetal blood levels of the drug are about 15% of those in maternal blood.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00609757
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  • 8
    Digitale Medien
    Digitale Medien
    Delayed contractures induced by external cadmium ions in rat soleus muscle fibres (2000)
    Springer
    Pflügers Archiv 439 (2000), S. 263-270 
    Details
    ISSN: 1432-2013
    Schlagwort(e): Activation of contractile proteins Cadmium ions Rat soleus muscle Skeletal muscle fibres Zinc ions
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. Cd2+-induced contractures began with a delay of ≅4 min after adding 3 mM Cd2+ to external solutions that contained Cl– as the major anion. Tension increased to ≅20% of peak tetanic tension after 30 min and was maintained after Cd2+ washout. Tension developed more rapidly at higher [Cd2+] (up to 10 mM). There was a lack of correlation between the delay before the contracture and contracture tension: (1) tension was reduced by 2 mM Co2+ or 50 µM nifedipine, although the delay remained at ≅4 min, and (2) the delay fell to seconds when Cd2+ was added in SO4 2– solutions, although tension was the same as in Cl– solutions. Since SO4 2– solutions swell T-tubules, Cd2+ may enter the T-system before inducing contractures. Cd2+-induced contractures depended on external [Ca2+] since they were reduced when Ca2+ was omitted from solutions. The contractures did not depend on activation of excitation–contraction coupling, since tension was not altered when the voltage sensor was inactivated by depolarization in 40 mM K+. A small contracture developed with 3 mM Zn2+, but not 3 mM Co2+ or La3+. Both Cd2+ and Zn2+ activated the contractile proteins in skinned fibres. Cd2+-induced contractures may depend on external Cd2+ releasing Ca2+ from the sarcoplasmic reticulum (SR), or on Cd2+ entering the fibre, releasing Ca2+ from the SR and/or directly activating the contractile proteins.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004249900165
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  • 9
    Digitale Medien
    Digitale Medien
    Phase II clinical trials of cisplatin-then-paclitaxel and paclitaxel-then-cisplatin in patients with previously untreated advanced epithelial ovarian cancer (2000)
    Springer
    Annals of oncology 11 (2000), S. 1603-1608 
    Details
    ISSN: 1569-8041
    Schlagwort(e): cisplatin ; ovarian cancer ; paclitaxel ; sequential chemotherapy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Purpose:To examine the activity and safety of two sequentiallyscheduled chemotherapy regimens comprising four cycles of paclitaxel (pctx)200 mg/m2/3 hours then four cycles of cisplatin (cisDDP) 100mg/m2, and vice versa, in patients with previouslyuntreated advanced ovarian cancer. Patients and methods:Between January 1994 and February 1996, werecruited 30 patients to the pctx-then-cisDDP regimen and 29 tocisDDP-then-pctx, in parallel phase II trials. Results:Both regimens were predictably active with responses seenin 22 of 30 patients (OR 74%; CR 27%, PR 47%) treatedwith pctx-then-cisDDP, as against 13 of 21 patients (OR 62%; CR38%, PR 24%) treated with cisDDP-then-pctx. The OR rate to fourcycles of pctx (induction) was 43%, with 27% diseaseprogression; the OR to four cycles of cisDDP (induction) was 57%, with5% progression. However, progression rates across both induction andconsolidation phases were 16% (pctx-then-cisDDP) and 29%(cisDDP-then-pctx). Both regimens were unacceptably neurotoxic, 11 patientssuffering grade 3 sensory neurotoxicity (5 on pctx-then-cisDDP, 6 oncisDDP-then-pctx) and 20 having grade 3 deafness (9 on pctx-then-cisDDP, 11on cisDDP-then-pctx). Conclusion:The activity of these sequential regimens justifiestheir further development using the less neurotoxic platinum analoguecarboplatin, perhaps combining paclitaxel with other platinum non-crossresistant drugs.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1008343519687
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  • 10
    Digitale Medien
    Digitale Medien
    Ultrasonic beam propagation through a bimetallic weld—A comparison of predictions of the Gauss-Hermite beam model and finite element method (1993)
    Springer
    Journal of nondestructive evaluation 12 (1993), S. 151-158 
    Details
    ISSN: 1573-4862
    Schlagwort(e): Beam propagation ; bimetallic weld ; Gauss-Hermite beam model ; finite element method ; ultrasonics ; anisotropic medium
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik , Mathematik
    Notizen: Abstract In this paper, predictions of two models for the propagation of ultrasonic beams through a two-dimensional, bimetallic weld geometry are compared. The finite element method can predict beam propagation through quite general geometry with high accuracy. This model, however, requires significant computational time. On the other hand, the approximate Gauss-Hermite model offers considerably greater computational speed, but has lower accuracy in certain regions and cannot treat the most general geometries and inhomogeneities in material properties. This paper compares the performances of the two models for the case of the two-dimensional, bimetallic weld consisting of multiple layers, some of which have anisotropic properties. It is found that the results of the two models are in good agreement in the vicinity of the central ray, and that the deviation increases as one moves away from the axis. Also, as the beam propagates through multiple interfaces, the accuracy of the Gauss-Hermite solution decreases.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00567571
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