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  • 1
    ISSN: 0340-1855
    Keywords: Schlüsselwörter Borrelien-Infektion ; diffuse Fasziitis ; Key words Borrelia burgdorferi infection ; diffuse fasciitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Diffuse fasciitis (DF) [diffuse fasciitis with eosinophilia – Shulman’s syndrome] has occasionally been linked to a precedent infection with Borrelia burgdorferi. Here, we report on another case of DF in a 25 year old male, in whom Borrelia burgdorferi infection as possible inciting agent could be identified based on the patient’s history and laboratory data. Efforts to microscopically demonstrate spirochetes or to amplify Borrelia-DNA by nested PCR in lesional tissue failed after antibiotic treatment had already been initiated. Although only a few cases of Borrelia associated diffuse fasciitis have been reported in the literature, the link between typical signs and symptoms as well as laboratory findings of Borrelia infection and the onset of diffuse fasciitis, starting at the primary site of EM, provide indirect evidence for a causative role of Borrelia burgdorferi as a potential infectious agent for DF.
    Notes: Zusammenfassung Infektionen mit Borrelia burgdorferi werden vereinzelt im Zusammenhang mit der Entwicklung einer diffusen Fasziitis (eosinophile Fasziitis – Shulman’s-Syndrom) beschrieben. Es wird über einen solchen Fall eines 25-jährigen Patienten berichtet, bei dem aufgrund der Anamnese und typischer labormedizinischer Befunde eine Borrelieninfektion als mögliche Ursache einer nachfolgenden diffusen Fasziitis angenommen werden kann. Der histologische und molekularbiologische Nachweis von Borrelien bzw. Borrelien-DNA (nested-PCR) im Hautexzisat gelingt nicht (mehr) nach schon auswärts begonnener Tetrazyklintherapie. In der Literatur sind wenige Einzelfallbeschreibungen hierzu publiziert. Diese kasuistischen Beobachtungen, die typische Anamnese und labormedizinischen Befunde sowie der enge zeitliche Zusammenhang in unserem Fall erlauben den Schluß, daß die diffuse Fasziitis gelegentlich durch einen Borrelieninfekt induziert werden kann.
    Type of Medium: Electronic Resource
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  • 2
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    Paris : Periodicals Archive Online (PAO)
    Revue de philologie, de littérature et d'histoire anciennes. ser.3:39=91 (1965) 317 
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  • 3
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    Paris : Periodicals Archive Online (PAO)
    Revue de philologie, de littérature et d'histoire anciennes. ser.3:39=91 (1965) 316 
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  • 4
    ISSN: 1432-0533
    Keywords: Key words Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) ; Hereditary multi-infarct dementia ; Skin biopsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is characterized clinically by recurrent cerebral infarcts, subcortical dementia and pseudobulbar palsy, and morphologically by a granular degeneration of cerebral and, to a lesser degree, extracerebral blood vessels. We present morphological findings in a further German family affected by CADASIL. The index case showed the typical periodic acid-Schiff-positive granular degeneration of vascular smooth muscle cells (VSMC) in cerebral vessels, which did not react with antibodies against various immunoglobulins or complement factors. Ultrastructurally, granular osmiophilic material (GOM) covered the VSMC in different cerebral regions as well as in extracerebral organs (muscle, nerve, skin, small and large intestine, liver, kidney and heart). Skin biopsy samples from other family members of the last two generations also revealed GOM irrespective of the clinical symptomatology (CADASIL, migraine only or asymptomatic). Patients in the third generation had higher amounts of GOM in skin vessels than did asymptomatic or migraine patients in the fourth generation. We conclude that skin biopsy is a useful and less-invasive screening method for the differential diagnosis of CADASIL.
    Type of Medium: Electronic Resource
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