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  • 1
    Electronic Resource
    Electronic Resource
    Lack of effect of magnesium-aluminium hydroxide on the absorption of theophylline given as a pH-dependent sustained release preparation (1993)
    Springer
    European journal of clinical pharmacology 44 (1993), S. 85-88 
    Details
    ISSN: 1432-1041
    Keywords: Theophylline ; Antacids ; Asthma ; slow-release formulations ; pharmacokinetics ; drug interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Antacids can modify the pharmacokinetic parameters of sustained-release preparations of theophylline by changing the gastric pH. Though this has been studied with various theophylline/antacid combinations, the specific preparations investigated here have not previously been tested. The objective of the study was to assess any change in the availability of theophylline from a sustained-release preparation (SR), induced by the coadministration with an antacid. The study was designed as a double-blind randomized crossover trial in the Pneumology Departments of three general hospitals. Fifteen patients were studied. They all had stable asthma treated with theophylline and no major organ failure or gastro-intestinal lesions requiring the use of antacids. The antacide (aluminium hydroxide 800 mg and magnesium hydroxide 800 mg), or placebo, tid, was added to a stable regimen of theophylline SR bid, for 4 days, in crossover fashion. Plasma theophylline concentrations were measured before and 1,2,3,4,6,8,10,12,16 and 24 h after the morning dose of Armophylline on the fourth day of each treatment period; the maximum plasma concentration (Cmax), and time to Cmax (tmax) were noted, and the area under the 24-h time-concentration curve (AUC0–24) and mean plasma concentration (Cmean) were computed. Peak expiratory flows on the same day, before and 3, 6 and 12 h after the morning dose of Armophylline were also measured. There was no change in any of the parameters studied. The addition of the antacide to theophylline, each given according to standard clinical practice, did not modify the pharmacokinetics of the latter. This result probably can not be generalized to all pairs of sustained-release theophylline-antacid preparations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315286
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  • 2
    Electronic Resource
    Electronic Resource
    Market analysis using Multiple Correspondence Analysis: the case of consumer acceptance of African catfish, Clarias gariepinus (Burchell, 1822) (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Aquaculture research 27 (1996), S. 0 
    Details
    ISSN: 1365-2109
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: In many countries, aquaculture development has been driven by technical solutions to the culture of high unit value (HUV) species. As rising production has met with falling prices, diversification into other HUV species has occurred and renewed the 'speciescycle’process. However, if aquaculture is to make its forecast contribution to offset declining capture supplies, some redirection may be needed to determine the substitute species and the product profile sought by consumers, and hence, the areas for genuine opportunity for growth. To this end, this paper employs Multiple Correspondence Analysis (MCA) to analyse consumer acceptance of a cultured product. The MCA identifies patterns of association hidden by conventional techniques and may provide a methodology for identifying more relevant responses by the international aquaculture industry to the needs of the market. To illustrate the potential, the paper presents a case study of African catfish, Clarias gariepinus (Burchell 1822), using face-to-face consumer surveys incorporating samples of Clarias fillets in household meals. The MCA suggests that the Clarias product has attributes which are not uniquely orientated to any particular niche market, in contrast to most conventional HUV species. This may be advantageous, and for example, suggests that Clarias might be marketed as frozen blocks for further added value products and as a substitute for those demersal species which are less available internationally.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2109.1996.tb00995.x
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  • 3
    Electronic Resource
    Electronic Resource
    A note on the behaviour of adult Atlantic halibut, Hippoglossus hippoglossus (L.), in cages (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Aquaculture research 25 (1994), S. 0 
    Details
    ISSN: 1365-2109
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract. Observations of adult Atlantic halibut, Hippoglossus hippoglossus (L.), behaviour in cages were made with underwater camera and video recording equipment. Significantly more fish (P 〈 0·01) were found on the cage bottom than in the water column, fish tending to congregate around the outside rather than in the centre of the cage. During rough weather, the cage bottom was observed to heave violently and proportionately fewer fish remained on the bottom, those which did adopting an arched body posture with heads and tails not in contact with the cage bottom. Around 25% of the caged fish were active at any time, most of the active fish remaining close to the cage surface or bottom, with little use being made of the remaining cage volume. Fish were observed to swim in a circular pattern close to the cage walls (mean velocity 0·53 m/s), maintaining such behaviour for periods of up to 5min with little change in swimming speed. Whilst all food types were ingested, items delivered directly lo the cage bottom were taken only if detected within the first minute or so. The implications for rearing Atlantic halibut in conventional cages are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2109.1994.tb00712.x
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  • 4
    Electronic Resource
    Electronic Resource
    The rôle of aquaculture in the industrial regions of the temperate zone (1985)
    Springer
    GeoJournal 10 (1985), S. 277-298 
    Details
    ISSN: 1572-9893
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography
    Notes: Abstract The prosperous industrial areas of North America and Europe support a diverse and vigorous aquaculture industry. Although climatic restrictions of temperature, photosynthetic energy and exposure may limit the potential, the relatively intensive forms of production of the area are supported by good and expanding market demand. Thus, many forms of production are technically sophisticated. Capital and operating cost levels are generally high and technically difficult. Poorly marketable products are not economically viable. The bulk of production is therefore concentrated on three fish groups: rainbow trout, Atlantic and Pacific salmon, channel catfish, and two mollusc groups: oysters and mussels. The potential for growth and development of the industry is good but is increasingly controlled by market expansion rather than by technical innovation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00462129
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    Paper (German National Licenses)
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