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  • 1
    Electronic Resource
    Electronic Resource
    The intramural pelvic nerves immunoreactive for calcitonin gene-related peptide in the rectum of normal and aganglionosis rat (1993)
    Springer
    Anatomy and embryology 187 (1993), S. 37-44 
    Details
    ISSN: 1432-0568
    Keywords: Calcitonin gene-related peptide ; Intramural pelvic nerve ; Aganglionosis rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The distribution of calcitonin gene-related peptide-like immunoreactive (CGRP-LI) nerves was investigated immunohistochemically in the rectum of normal, capsaicin-treated and congenital aganglionosis rats. The rectum of the normal rat was densely supplied with both extrinsic and intrinsic nerves exhibiting CGRP-like immunoreactivity. Numerous CGRP-LI nerve fibres were seen in both the myenteric and submucous plexuses. Intrinsic CGRP-LI nerve cell bodies were sparsely found in both the ganglionated plexuses, while a large inflow of extrinsic CGRP-LI nerves was characteristically observed in the rat rectum. CGRP-like immunoreactive fibres were abundant in the intramural pelvic nerves which ascend proximally in the intermuscular zone and connect with the myenteric plexus of the rat distal bowel. As compared with CGRP-positive fibres, SP- or SK-positive fibres in the intramural pelvic nerves were far less frequent. The treatment with capsaicin in the neonatal period led to a marked depletion of CGRP-immunoreactivity in these extrinsic nerves as well as in the most terminal varicose fibres seen in the whole layers of the rectal wall. These findings suggest that the vast majority of CGRP-LI fibres in the intramural pelvic nerves are sensory in nature, and that the positive nerve fibres of extrinsic origin directly innervate each layer of the rat rectum. These CGRP-LI sensory fibres associated with the intramural pelvic nerves, may be of importance in the regulation of rectal and colonic function in normal rats. A dense innervation of CGRP-LI nerve fibres, some of which showed the varicose appearance, was also found in the rectum of congenital aganglionosis rats. Thus, it is suggested that there is a large inflow of extrinsic CGRP-LI fibres from the pelvic plexus in the affected rectum. The extrinsic CGRP-LI nerves in the aganglionic segment of the mutant rat might also be related to the regulation of rectal function, providing afferent pathways.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00208195
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  • 2
    Electronic Resource
    Electronic Resource
    Ultrastructure of the onion bulb-like lamellated structure observed in the sural nerve in a case of von Recklinghausen's disease (1972)
    Springer
    Acta neuropathologica 20 (1972), S. 258-263 
    Details
    ISSN: 1432-0533
    Keywords: Electron Microscopy ; Sural Nerve ; von Recklingshausen's Disease ; Schwann Cell ; Onion Bulb
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Examination of photo and electron microscopical preparations of a biopsied sural nerve from a patient with von Recklinghausen's disease is reported. In the toluidine blue stained Epon-sections the number of myelinated fibers per square millimeter was moderately decreased and the number of large myelinated fibers was severely reduced. Large, circular, lamellated structures which resemble the onion bulb were observed. These structures are different from the previously reported onion bulb in their size and core structure which contains usually a degenerated nerve fiber. Some consideration was given to the origin of these onion bulb-like lamellated structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686907
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  • 3
    Electronic Resource
    Electronic Resource
    Intratumorous distribution of catecholaminergic clone cells of human neuroblastoma (1986)
    Springer
    Virchows Archiv 409 (1986), S. 571-582 
    Details
    ISSN: 1432-2307
    Keywords: Neuroblastoma ; Catecholamine fluorescence ; Catecholamine content ; Catecholaminergic clone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The intratumorous distribution of catecholaminergic clone cells in 23 human neuroblastomas was studied using Falck-Hillarp's method, and the findings compared with the catecholamine (CA) content within the tumour. All the specimens contained elements with CA fluorescence, and the pattern of fluorescence was classified from the distribution of CA-positive cells and neurofibrils, as diffuse cellular (DC); diffuse fibrillary (DF), sporadic (S), clustered (C), island-shaped (I), and bundled (B). The strength of CA fluorescence of both cellular and fibrillary elements correlated well with the CA content within the tumour. In addition, all tumours of urinary VMA-negative cases also contained significantly larger amounts of CA than other, non-functioning, tumours in the paediatric age group. The results of this study suggest that firstly, the ratio of CA-positive cells to CA-positive neuronal processes is proportionately higher in the poorly-differentiated neuroblastomas and that secondly, even tumours negative for urinary VMA or HVA might be polyclonal and contain catecholaminergic elements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00713425
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  • 4
    Electronic Resource
    Electronic Resource
    The distribution and co-localization of nitric oxide synthase and vasoactive intestinal polypeptide in nerves of the colons with Hirschsprung's disease (1997)
    Springer
    Virchows Archiv 430 (1997), S. 53-61 
    Details
    ISSN: 1432-2307
    Keywords: Nitric oxide synthase ; NADPH-diaphorase ; Vasoactive intestinal polypeptide ; Enteric nervous system ; Hirschsprung's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The distribution and co-localization of nitric oxide synthase (NOS) and vasoactive intestinal polypeptide (VIP) were examined by means of immunohistochemistry and NADPH diaphorase (NADPH-d) histochemistry in the gut of patients with Hirschsprung's disease. In the normoganglionic segment, many nitrergic nerve cells were localized in Auerbach's plexus and nerve fibres were observed preferentially in the circular muscle. The submucosal nitrergic nerve cells were mainly situated in Schabadasch's plexus with occasional cells demonstrable in Meissner's plexus. NOS and VIP were co-localized in most ganglion cells of Auerbach's plexus. In the oligoganglionic segment, a marked reduction of NOS- and VIP- positive nerve cells and fibres was noticed in both the myenteric and submucosal plexuses, and nitrergic fibres had disappeared in the inner layer of the circular muscle. In the aganglionic segment, NOS and VIP were revealed only in extrinsic nerve fasciculi and rami and co-localized in a few fibres. From these observations, the inner layer of the circular muscle of the oligoganglionic segment and the whole of the muscularis propria of the aganglionic segment were considered to be totally lacking in nitrergic innervation. Nitrergic nerves of the human colon comprise both intrinsic and extrinsic elements and the majority of intrinsic nitrergic nerve cells contain VIP. Very low numbers of extrinsic nitrergic fibres contain VIP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01008017
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  • 5
    Electronic Resource
    Electronic Resource
    Enteric nervous system and endocrine cells demonstrated in the gut in teratomas (1993)
    Springer
    Virchows Archiv 422 (1993), S. 499-506 
    Details
    ISSN: 1432-2307
    Keywords: Teratoma ; Fetus in fetu ; Enteric nervous system ; Epithelial endocrine cell ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case of retroperitoneal teratoma, showing considerable morphological development presented as an encapsulated and pedunculated tumour with a seemingly mature intestinal loop. Markedly complex intramural nerve plexuses and numerous epithelial endocrine cells were revealed immunohistochemically in the gut tissue. Ten other mature teratomas containing gastrointestinal tissues were examined for comparison, but neither intramural ganglia nor nervous networks were found in the gut components, despite the presence of amine- and/or peptide-containing endocrine cells in all intestinal mucosa linings. Enteric endocrine cells were found to occur irrespective of the differentiation of intestinal layers or the occurrence of neural elements. These findings suggest that the epithelial endocrine cells of intestinal mucosa do not have the same origin as enteric neurons, but are rather of endodermal origin. This invertebrate well-formed teratoma, containing a highly organized enteric nervous system, suggests that teratoma and fetus in fetu are related entities distinguished by the presence of a vertebral axis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01606460
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  • 6
    Electronic Resource
    Electronic Resource
    Histochemical observation on the phosphatase activities of the differentiating taste bud (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 61-66 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Adenosine triphosphatase, alkaline phosphatase and acid phosphatase activities of the developing taste buds were observed histochemically in the rat circumvallate papilla.Adenosine triphosphatase activity was already demonstrable in a cluster of cells in the epithelium of the papilla on the first day of birth, when taste buds could not yet be morphologically identified. The cells with the activity are certainly considered as the differentiating taste bud cells. These cells took the form of a bud similar to the adult one about the fourth day of life.Alkaline phosphatase activity was demonstrated first on the superficial cell layers of the epithelium of its apical surface as well as on that of the epithelium in the gutter of circumvallate papilla just after birth. The activity in the gutter then rapidly increased, while the activity of the apical surface abruptly decreased and disappeared on the second day of life.Acid phosphatase was demonstrable only in some cells of the taste bud on the fourth day of life. The final pattern of the activity, which is found in the supranuclear cytoplasm of taste bud cells, was established after the eighth day of life.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091650107
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  • 7
    Electronic Resource
    Electronic Resource
    Histochemical observation on phosphatase activities of degenerating and regenerating taste buds (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 31-38 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Using rat's circumvallate papillae, ATPase, alk. Pase and acid Pase of taste buds were observed after the transection of the glossopharyngeal nerve.The taste buds began to disappear after the nerve was cut and were completely lost after ten days. Following the regeneration of the glossopharyngeal nerve, taste buds reappeared from the bottom of the gutters of circumvallate papillae about 25 days after the operation.ATPase was strongly present on the cell membrane of taste bud cells as far as they existed during degeneration and regeneration. Alk. Pase, which is normally localized on the superficial layers of the epithelium overlying the gutters of circumvallate papilla, gradually diminished as the taste buds degenerated and reappeared as the taste buds regenerated; that is, the activity began to diminish three days after the operation, became feeble after ten days and reappeared after 25 days. It is concluded that taste bud cells secrete alk. Pase in the gutters of circumvallate papillae. Acid Pase activity, usually found in the supranuclear portion of taste bud cells, was intensely reactive during degeneration but did not reappear at the early stage of regeneration of taste bud cells.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091630104
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  • 8
    Electronic Resource
    Electronic Resource
    A monoamine in the gustatory cell of the frog's taste organ (1975)
    Springer
    Cell & tissue research 159 (1975), S. 101-108 
    Details
    ISSN: 1432-0878
    Keywords: Taste organ ; Frog ; Monoamine ; Histochemistry ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Fluorescence histochemistry reveals that in the frog's taste organ a yellow fluorescence is regularly observed at the most basal region of the sensory epithelium. The fluorescence has a strong intensity, but it fades rapidly upon the UV-irradiation. The peak of the emission spectrum is at 520 mμ. Following reserpine treatment the yellow fluorescence is markedly reduced, but not depleted completely. From these characteristics the monoamine fluorescence is regarded as representing 5-HT (serotonin). The ultrastructural study on sensory epithelia shows that the terminal portions of gustatory cell processes are localized at the basal region. These portions are filled with dense cored vesicles (700–1000 Å in diameter) and frequently opposed with nerve fibers penetrating into the epithelium. The gustatory cell processes are also interposed between the terminal portions or nerve fibers. The cytoplasm of the gustatory cell process is characterized by many mitochondria, fine filaments and glycogen particles, but contains few cored vesicles. The distribution of terminal portions of gustatory cell processes seems to correspond fairly well to that of the monoamine fluorescence observed discontinuously along the basal lamina. Accordingly it is concluded that the fluorigenic monoamine is localized in the cored vesicles of the gustatory cell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00231999
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  • 9
    Electronic Resource
    Electronic Resource
    Immunohistochemical identification of supportive cell types in the enteric nervous system of the rat colon and rectum (1988)
    Springer
    Cell & tissue research 251 (1988), S. 523-529 
    Details
    ISSN: 1432-0878
    Keywords: Glial fibrillary acidic (GFA) protein ; S-100 protein ; Supportive cells ; Intestine ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The non-neuronal, supportive cells of the enteric nerve plexus were investigated in the colon and rectum of adult and developing rats by means of immunohistochemistry, utilizing antisera against GFA protein and S-100 protein. Immunoreactivity to GFA protein was almost exclusively found in cells associated with the myenteric plexus and a small number of cells within the submucous ganglia. On the other hand, the use of S-100 protein antiserum resulted in the visualization of all supportive elements in the enteric nervous system. However, two types of supportive cells could be tentatively differentiated in the enteric nerve plexus during the second week of postnatal development, using GFA protein and S-100 protein antisera; GFA protein-positive cells were clearly discernible from S-100 protein-positive cells in terms of both the morphological profiles and immunohistochemical properties. It was assumed that at least two different types of supportive cells are contained in the enteric nerve plexus. We suggest that in the enteric nervous system the terms “glial cells” and “Schwann cells” should be employed to designate the supportive cells containing GFA and S-100 proteins, and cells containing S-100 protein, respectively. We discuss the possibility that glial cells are associated with the parasympathetic preganglionic fibres directly derived from the central nervous system, while Schwann cells originate from the neural crest.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00213999
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  • 10
    Electronic Resource
    Electronic Resource
    Fine structure of monoamine-containing basal cells in the taste buds on the barbels of three species of teleosts (1984)
    Springer
    Cell & tissue research 235 (1984), S. 479-484 
    Details
    ISSN: 1432-0878
    Keywords: Monoamine-containing cells ; Taste bud ; Paracrine cells ; Mechanoreceptors ; Electron microscopy ; Teleosts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The taste buds on the barbels in three species of teleosts (Cyprinus carpio, Misgurnus anguillicaudatus, Parasilurus asotus) were studied by means of fluorescence and electron microscopy. Intensely yellow-fluorescent cells, which are disk-shaped and located exclusively in a basal position, are observed in the barbel-buds of all fishes examined. The basal cells contain a large number of small clear vesicles approximately 40–60 nm in diameter, which show a tendency to aggregate in the cytoplasm facing the junction of the nerve terminals; chemically transmitting synapses are seen in the latter region. It is suggested from the present observations that the basal cells in the barbel-bud may originate from Schwann cells and have a dual function both as mechanoreceptors and paracrine elements. Since the administration of 5,6-DHT results in an appearance of small dense vesicles among the small clear vesicles, the possibility exists that the basal cell may be capable of taking up monoamines and storing them in the small clear vesicles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00226942
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