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  • 1
    Electronic Resource
    Electronic Resource
    Autonomic nervous activity before and after eradication of Helicobacter pylori in patients with chronic duodenal ulcer (2002)
    Oxford UK : Blackwell Science Ltd.
    Alimentary pharmacology & therapeutics 16 (2002), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Helicobacter pylori infection is involved in the formation of chronic peptic ulcer. However, a previously reported hypothesis concerning the involvement of central autonomic nervous disorder in this condition cannot be ruled out.〈section xml:id="abs1-2"〉〈title type="main"〉Aim:To use spectrum analysis of heart rate viability to examine autonomic nervous activity before and after H. pylori eradication.〈section xml:id="abs1-3"〉〈title type="main"〉Methods:Twenty patients with chronic duodenal ulcer (duodenal ulcer group) and 20 age-matched normal adults (N group). In both groups, 24-h Holter electrocardiograms (ECGs) were recorded and spectrum analysis of heartrate variability was performed. In the duodenal ulcer group, Holter ECG was recorded before and after H. pylori eradication.〈section xml:id="abs1-4"〉〈title type="main"〉Results:In the N group, analysis of heart rate variability showed that high frequency (HF) power, an index of parasympathetic activity, was high at night, while the low frequency (LF)/HF ratio, an index of sympathetic function, was high during the daytime. In the duodenal ulcer group, HF power was higher at night than during the daytime, showing a similar pattern to the N group, but the power value was higher than in the N group (P 〈 0.05). In the duodenal ulcer group, LF/HF at night was significantly higher than that of the N group. In addition, in the duodenal ulcer group, autonomic activity after H. pylori eradication did not differ significantly from that before H. pylori eradication.〈section xml:id="abs1-5"〉〈title type="main"〉Conclusions:In patients with chronic peptic ulcer, both sympatheticotonia and parasympatheticotonia may occur at night, and this abnormality in autonomic nervous activity may cause increased gastric acid secretion and gastric mucosal vasoconstriction. Abnormalities in autonomic activity persist even after H. pylori eradication, suggesting that they may be an independent risk factor in the formation of chronic peptic ulcer in addition to H. pylori infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.16.s2.27.x
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  • 2
    Electronic Resource
    Electronic Resource
    Is autonomic dysfunction a necessary condition for chronic peptic ulcer formation? (2000)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 14 (2000), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: The relationship between 1/f fluctuation of the heart rate variability and Helicobacter pylori infection was evaluated, in order to clarify whether autonomic nervous dysfunction is a necessary condition for chronic peptic ulcer formation. Methods: The subjects were 11 patients with recurrent chronic peptic ulcer and 20 age-matched normal subjects. Holter ECGs were recorded over 24 h, and the 1/f –x fluctuation of the heart rate was computed. The 1/f –x fluctuation of the heart rate is a novel index of autonomic function that has been shown to reflect a patient's pleasant mood. For 1/f –x fluctuation, the slope of the regression line (–x) was determined and cosine fitting of the absolute slope of the regression line over a 24-h period was performed. Results: For the normal group, the absolute slope of the regression line during daytime and night-time were 0.53 ± 0.16 and 1.05 ± 0.18, respectively. For the peptic ulcer group, the corresponding values during daytime and night-time were 0.94 ± 0.15 and 1.84 ± 0.18, respectively. The mean value of the cosine curve was 0.76 ± 0.23 in the normal group and 1.12 ± 0.25 in the peptic ulcer group. Thus, these values were significantly higher for the latter group than for the former group (P 〈 0.05). No statistically significant difference in H. pylori infection between the two groups was observed. Conclusions: Autonomic nervous dysfunction as well as H. pylori infection appears to be a necessary condition for chronic peptic ulcer formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2000.014s1082.x
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  • 3
    Electronic Resource
    Electronic Resource
    DNA typing for Helicobacter pylori isolates from eradication-failed patients: comparison of the isolates before and after therapy (2004)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 20 (2004), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Failure of Helicobacter pylori eradication occurs frequently despite use of multiple microbial agents.Aim : We aimed to study differences between H. pylori strains isolated before and after eradication failure.Methods : We treated 87 patients with peptic ulcer using triple therapy consisting of omeprazole plus combinations of clarithromycin, amoxicillin, or metronidazole. We studied the status of cagA, vacA, and iceA by PCR, and examined the differences in H. pylori isolates by pulsed-field gel electrophoresis and arbitrary primer polymerase chain reaction. The minimum inhibitory concentration of clarithromycin, amoxicillin, or metronidazole was determined by an agar dilution method.Results : Eradication therapy failed in 12 patients (14%); H. pylori isolates were obtained from all of these both before and after therapy. After eradication therapy, 10 patients were colonized with the same strain as before therapy, while the other two patients were colonized with different strains from those before therapy. In the former group, one isolate changed from metronidazole-sensitive to -resistant, one changed from clarithromycin- and metronidazole-sensitive to -resistant, and four were resistant to clarithromycin or metronidazole both before and after therapy. The other four isolates remained sensitive to clarithromycin and metronidazole after therapy. In the two patients who yielded apparently different isolates after therapy, they changed from clarithromycin- and metronidazole-sensitive to -resistant.Conclusion : Eradication of H. pylori by first-line therapy is an important goal in the treatment of H. pylori-positive peptic ulcer, and that appropriate antimicrobial sensitivity testing should be conducted in patients with eradication failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2004.01968.x
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  • 4
    Electronic Resource
    Electronic Resource
    β-Lactamase inhibitors have antibacterial activities against Helicobacter pylori (1999)
    Springer
    Journal of infection and chemotherapy 5 (1999), S. 206-207 
    Details
    ISSN: 1437-7780
    Keywords: Key wordsHelicobacter pylori ; β-Lactamase inhibitor ; Amoxicillin ; Clarithromycin ; Azithromycin ; Antibacterial activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recently, it was reported that amoxicillin-clavulanate has slightly higher activity than amoxicillin against Helicobacter pylori. In this study, we evaluated the in-vitro antibacterial activity of β-lactamase inhibitors against H. pylori. We investigated the susceptibility of 30 H. pylori strains to β-lactamase inhibitors, including clavulanate, sulbactam, and tazobactam. In short-term bactericidal studies, a clinical isolate of H. pylori NU27 was exposed to 1 × minimum inhibitory concentration (MIC) of the β-lactamase inhibitors, amoxicillin, clarithromycin, and amoxicillin-clavulanate for 3 and 6 h. The MICs90 for these β-lactamase inhibitors were 2, 4, and 2 mg/l, respectively. The short-term bactericidal studies showed that these β-lactamase inhibitors decreased viable counts of H. pylori during 6-h exposure at 1 × MIC. Our results suggest that β-lactamase inhibitors have in-vitro antibacterial activity against H. pylori. Amoxicillin and clavulanate used in combination resulted in increased antibacterial activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101560050036
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  • 5
    Electronic Resource
    Electronic Resource
    Stress and coping behavior in patients with diabetes mellitus (2000)
    Springer
    Acta diabetologica 37 (2000), S. 61-64 
    Details
    ISSN: 1432-5233
    Keywords: Key words Diabetes mellitus ; Coping scale ; Stress tolerance ; Diabetes education ; Stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Diabetes mellitus is a disease which must be controlled over the lifetime of a patient. We investigated the issues of stress and coping for diabetes mellitus which may influence self-management. In addition, we examined the association of these factors with blood glucose control, in order to review self-management instructions for diabetes mellitus. The study included 153 patients with diabetes mellitus. The patients were divided into two subgroups: good-control group, comprising patients with glycohemoglobin (HbA1c) values less than 7.0%; and poor-control group, comprising those with HbA1c values of 7.0% or more. All patients responded to a questionnaire regarding stress tolerance, Jalowiec and Power's coping scale and awareness of diabetes mellitus. Stress tolerance was not significantly different between the good-control and poor-control groups. No significant gender differences in coping score were evident for the good-control group. However, in the poor-control group, the coping score in men was significant higher than that in women. The problem-oriented coping score for men in the poor-control group was significantly higher than that for the good-control group (p 〈 0.01). In a comparison of awareness of diabetes mellitus, the proportion of patients who replied that they were rigidly following diabetes treatment was higher in the poor-control group than the good-control group. Patients with diabetes mellitus may have a knowledge of the disease and a strong will to resolve problems. This is especially true for male patients in that their will appeared to be stronger, but they may not have the resolve to establish appropriate behavior patterns. In the future, methods for evaluating self-management should be included in diabetes education.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005920070020
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  • 6
    Electronic Resource
    Electronic Resource
    Types of methicillin-resistantStaphylococcus aureus associated with high mortality in patients with bacteremia (1996)
    Springer
    European journal of clinical microbiology & infectious diseases 15 (1996), S. 340-343 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Forty-seven strains of methicillin-resistantStaphylococcus aureus (MRSA) isolated from 47 patients with bacteremia were analyzed by chromosomal DNA digestion pattern using pulsed-field gel electrophoresis and evaluated for serological coagulase type, enterotoxin type, and toxic shock syndrome toxin-1 production. The mortality rate was significantly higher in the older patients (≥51 years of age) than in the younger patients (≤50 years of age) (50% vs. 4%, p=0.0007). Methicillin-resistantStaphylococcus aureus strains of serological coagulase type II were more likely to be associated with mortality in older patients than were strains of the other types (p=0.037).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01695669
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