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  • 1
    Electronic Resource
    Electronic Resource
    Prospektiver Vergleich der diagnostischen Wertigkeit von Zytologie und Immunzytologie bei thorakoskopisch-bioptisch untersuchten Pleuraergüssen (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 400-406 
    Details
    ISSN: 1432-1440
    Keywords: Pleural effusion ; Thoracoscopy ; Immunocytology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two issues have been elaborated: (1) the value of immunocytochemistry in the diagnosis of pleural effusions, and (2) the reactivity of the investigated antibodies with different classes of cells in pleural effusions. Effusions of unknown origin from 38 patients were investigated using thoracoscopy, pleural biopsies, conventional cytology, and immunocytochemistry. The following antibodies were used: those monoclonal against various leukocyte antigens, macrophage antigens, epithelial membrane antigen (EMA), various cytoskeleton antigens, and melanoma antigens; those polyclonal against CEA and ferritin. All of the techniques used showed 18 patients (48%) as having a tumor-cell negative effusion. A pleural tumor with a malignant effusion showed in 13 patients (34%); in 12 of these immunocytochemistry also revealed tumor cells. Seven patients (18%) had a tumor of the pleura with a tumor-cell negative effusion; in 2 of these immunocytochemistry revealed a tumor-cell positive effusion. There was no difference with regard to the number of NK cells in patients with inflammation of the pleura and negative cytology and patients with tumor of the pleura and malignant effusion (3% vs 4.5%). Tumor cells were mainly stained by EMA, cytokeratin, and CEA. CEA was the only antibody to be tumor-cell specific, while EMA and cytokeratin were expressed by mesothelial cells also. The antibody against ferritin was a significant marker for mesothelial cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01715761
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  • 2
    Electronic Resource
    Electronic Resource
    Lymphocytosis of large granular lymphocytes associated with anemia and neutropenia: Proof of monoclonality of the LGL-population, but benign clinical course (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 588-591 
    Details
    ISSN: 1432-1440
    Keywords: Large granular lymphocytosis ; Clinical features ; Hemopoiesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 37-year-old man with severe transfusion-requiring anemia and neutropenia associated with lymphocytosis of large granular lymphocytes (LGLs) has been followed over a period of 3.5 years. Detailed phenotyping of the LGL has been performed, revealing a phenotype of CD3+, CD8+, CD16+, HLA-DR+, and Leu-7+. Southern-blot analysis of the T-cell receptor beta-chain locus detected a gene rearrangement, thus providing proof of monoclonality of the peripheral blood LGLs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01721686
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  • 3
    Electronic Resource
    Electronic Resource
    Gastric MALT-lymphoma and Helicobacter pylori infection (1997)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 11 (1997), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The presence of lymphoid tissue in the gastric mucosa is virtually pathognomonic of Helicobacter pylori infection. This lymphoid tissue has mucosa–associated lymphoid tissue (MALT) characteristics suggesting that H. pylori infection may represent a stimulus for the growth of gastric MALT lymphoma. H. pylori can be detected in more than 90% of patients with low–grade gastric MALT lymphoma supporting the aetiological role of the organism. The strongest evidence for the significance of H. pylori in the pathogenesis of low aetological–grade gastric MALT lymphoma is provided by clinical studies showing that cure of H. pylori infection is followed by a complete regression of these tumours in most patients. This paper reviews the current knowledge about antibacterial treatment of low–grade gastric MALT lymphoma, and immunological and molecular aspects in the pathogenesis of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.11.s1.12.x
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  • 4
    Electronic Resource
    Electronic Resource
    Lateral eye movements as an indication of hemispheric preference: an EEG validation study
    Amsterdam : Elsevier
    International Journal of Psychophysiology 6 (1988), S. 177-184 
    Details
    ISSN: 0167-8760
    Keywords: Cognitive processing ; Electroencephalography ; Event-related desynchronisation ; Hemispheric asymmetry ; Hemisphericity ; Lateral eye movement
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-8760(88)90003-7
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  • 5
    Electronic Resource
    Electronic Resource
    Zur reaktion von trans-chalkonepoxiden und stereoisomeren chlorhydrinen mit hydrazin
    Amsterdam : Elsevier
    Tetrahedron 28 (1972), S. 3241-3250 
    Details
    ISSN: 0040-4020
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0040-4020(01)93665-8
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  • 6
    Electronic Resource
    Electronic Resource
    High speed immuno-affinity chromatography on supports with gigapores and porous glass (2000)
    Springer
    Bioseparation 9 (2000), S. 259-268 
    Details
    ISSN: 1573-8272
    Keywords: porous glass beads ; Convective Interactive Media ; Affinity purification ; high throughput ; flag-tag
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Immuno-affinity chromatography exploiting the Ca2+ dependent interaction of the anti-Flag antibody and Flag-tagged proteins has been investigated. The antibody has been immobilized on porous glass beads (Prosep) containing gigapores and on a monolith, the polymethacrylate based Convective Interactive Media (CIM) column at a ligand density of 2 mg/g and 10 mg/ml respectively. The performance of the columns was assessed by applying clarified yeast culture supernatant containing overexpressed Flag-human serum albumin. Dynamic binding capacity and purity was checked at various flow rates ranging from 100 cm/h to 800 cm/h. 95% purity could be obtained. Anti Flag-CIM columns showed a higher unspecific adsorption, requiring a longer wash cycle to obtain the same purity compared to the Prosep column. Anti Flag-CIM columns showed a flow independent performance, which is explained by its monolithic structure. A decreasing dynamic binding capacity with flow was observed with anti-Flag-Prosep columns. Both columns are suited to purify milligrams of protein out of a yeast culture supernatant within a few minutes. We considered them as promising candidates for high throughput screening, where fast purification is a necessity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1011130821804
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  • 7
    Electronic Resource
    Electronic Resource
    A variant of finite-dimensional Tikhonov regularization with a-posteriori parameter choice (1988)
    Springer
    Computing 40 (1988), S. 91-109 
    Details
    ISSN: 1436-5057
    Keywords: 65R20 ; 45L10 ; Integral equations ; Tikhonov regularization ; parameter selection method
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Zusammenfassung In dieser Arbeit betrachten wir eine besondere Variante endlich-dimensionaler Tikhonov-Regularisierung schlechtgestellter Operatorgleichungen. Konvergenzraten werden nachgewiesen und eine a-posteriori Parameterwahl wird hergeleitet, die optimale Konvergenzraten bezüglich des Datenfehlers und der endlich-dimensionalen Approximation liefert, ohne Information über die exakte Lösung zu benötigen. Schließlich präsentieren wir auch einige numerische Beispiele, bei denen lineare Splinefunktionen verwendet werden, die die theoretischen Ergebnisse bestätigen.
    Notes: Abstract In this paper we consider a particular variant of finite-dimensional Tikhonov regularization for ill-posed operator equations. Convergence rates are established and an a-posteriori parameter choice method is derived that leads to optimal convergence rates with respect to data errors and with respect to the finite-dimensional subspace, without using any information about the exact solution. Finally, using linear splines we present several numerical examples that confirm the theoretical results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02247939
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  • 8
    Electronic Resource
    Electronic Resource
    Numerical realization of an optimal discrepancy principle for Tikhonov-regularization in Hilbert scales (1987)
    Springer
    Computing 39 (1987), S. 43-55 
    Details
    ISSN: 1436-5057
    Keywords: Primary 65 R 20 ; secondary 45 L 10 ; Tikhonov-regularization ; Hilbert scales ; discrepancy principle ; linear integral equations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Zusammenfassung Wir diskutieren die numerische Realisierung einer a-posteriori Parameterwahl für die Tikhonov Regularisierung von linearen Integralgleichungen erster Art in Hilbertskalen, die optimale Konvergenzraten liefert und die keine Information über die exakte Lösung benötigt. Numerische Beispiele bestätigen die theoretischen Ergebnisse.
    Notes: Abstract We discuss the numerical realization of an a-posteriori parameter choice for Tikhonov regularization of linear integral equations of the first kind in Hilbert scales that leads to optimal convergence rates and that does not need any information about the exact solution. Numerical examples confirm the theoretical results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02307712
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  • 9
    Electronic Resource
    Electronic Resource
    Detection of allelic loss within the β1-interferon gene in childhood acute lymphoblastic leukemia using differential PCR (1994)
    Springer
    Annals of hematology 68 (1994), S. 171-174 
    Details
    ISSN: 1432-0584
    Keywords: Differential PCR ; Β1-IFN gene loss ; Acute lymphoblastic leukemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Deletion of the short arm of chromosome 9p involving the Β1-interferon (IFN) gene has been implicated in the process of malignant transformation in lymphomas and acute lymphoblastic leukemias. Since cytogenetic analysis is frequently unsuccessful in clinical samples, we used a recently described differential PCR technique to detect losses within the Β1-IFN gene in 86 acute leukemias. Using differential PCR, no Β1-IFN deletion was detected in 44 acute myeloid leukemia (AML) and eight control samples. However, five of 42 acute lymphoblastic leukemia (ALL) probes (12%) exhibited loss of the Β1-IFN gene (three common ALL, two T-ALL). Cytogenetic analysis was performed independently in three of these five cases and revealed abnormalities of chromosome 9p in two samples. Two of five T-ALL cases exhibited a loss within the Β1-IFN gene, compared with 3/29 c-ALLs, suggesting a predominance of IFN gene loss in T-ALLs. These data indicate that PCR can be used for rapid detection of gene dosage phenomena in clinical leukemia samples.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01834362
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  • 10
    Electronic Resource
    Electronic Resource
    Outcome of peripheral blood stem cell mobilization in advanced phases of CML is dependent on the type of chemotherapy applied (1998)
    Springer
    Annals of hematology 77 (1998), S. 21-26 
    Details
    ISSN: 1432-0584
    Keywords: Key words CML ; Chemotherapy ; PBSC mobilization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  High-dose chemotherapy with autologous transplantation of in vivo purged PBSC is a novel investigational approach to treating chronic myelogenous leukemia (CML) patients not responsive to conventional therapy with interferon-α (IFN-α) and not eligible for allogeneic transplantation. PBSC mobilization using either '5+2/7+3'-type chemotherapy or 'mini-ICE/ICE' chemotherapy was investigated in 43 patients with advanced phases of Philadelphia (Ph)-positive CML. Thirty patients were in late chronic phase (〉12 months post diagnosis) and 13 patients in accelerated phase (AP) or blast crisis (BC). Contamination with Ph-positive cells was evaluated in harvests from 37/43 patients. The outcome of PBSC mobilization was dependent on the type of chemotherapy administered: a complete or major cytogenetic response (〈35% Ph-positive metaphases) in leukapheresis collections was obtained in ten of 15 patients treated with 'mini-ICE/ICE' but in only three of 28 patients treated with '5+2/7+3' chemotherapy. One patient (1/43) in blast crisis died during mobilization therapy (2%). Twenty-five patients underwent PBSC transplantation and all of them engrafted successfully. Transplantation-related mortality was 0%. The data show that in advanced phases of CML the chance of harvesting Ph-negative peripheral blood stem cells depends on the type of chemotherapy used for mobilization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050406
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