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  • 1
    Electronic Resource
    Electronic Resource
    A direct approach to study the messenger properties of influenza-virion RNA
    Amsterdam : Elsevier
    FEBS Letters 34 (1973), S. 145-146 
    Details
    ISSN: 0014-5793
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(73)80778-1
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  • 2
    Electronic Resource
    Electronic Resource
    12 Thymus hormones in histiocytosis-X
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 28 (1987), S. 220 
    Details
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-4731(87)91695-5
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  • 3
    Electronic Resource
    Electronic Resource
    Die Häufigkeit von Chlorophyllmutationen nach Röntgenbestrahlung eines heterozygoten M2-Saatgutramsches bei Gerste (1965)
    Springer
    Theoretical and applied genetics 35 (1965), S. 98-102 
    Details
    ISSN: 1432-2242
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00709515
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  • 4
    Electronic Resource
    Electronic Resource
    Myopathic carnitine deficiency associated with lymphocytic malignant non-hodgkin lymphoma and monoclonal immunoglobulin G-K (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 669-674 
    Details
    ISSN: 1432-1440
    Keywords: Myopathy ; Carnitine deficiency ; Lymphocytoma ; Muscle biopsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 47-year-old male patient suffered from recurrent myalgia, induced by fasting or physical exercise. Later, he developed progressive muscular weakness. Serum levels of creatine phosphokinase (CPK) were elevated to approx. 400 U/l. Muscle biopsies showed lipid storage myopathy and signs of acute fiber necrosis, muscle carnitine was decreased to below 20% of controls, carnitine palmitoyl transferase (CPT) activity was normal. Carnitine was also moderately decreased in a liver biopsy and in plasma. Urine excretion of carnitine was low, no elevation of short-chain dicarboxylic acids could be found. The patient was also found to suffer from a lymphocytic malignant non-Hodgkin lymphoma, a monoclonal immunoglobulin (Ig) G-k in plasma and lymphocytic infiltration of bone marrow were demonstrated. At that time no evidence had been obtained to indicate that these two diseases could be related to each other. Autoantibodies against skeletal muscle could not be demonstrated. Absorption of L-carnitine p.o. was normal, however, plasma levels of carnitine fell again rapidly. Administration of 3 × 2 g L-carnitine per day normalized the patient's plasma carnitine levels and led to an increase of plasma short-chain acylcarnitine and ketone bodies, particularlyβ-hydroxybutyrate (B-HOB). However, no significant clinical improvement could be seen. Additional application of prednisone led to normalization of CPK serum levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716463
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  • 5
    Electronic Resource
    Electronic Resource
    High-dose chemotherapy and reinfusion of haematopoietic stem cells advanced germ cell tumours with poor prognosis in 1996 (1997)
    Springer
    Der Urologe 36 (1997), S. 561-564 
    Details
    ISSN: 1433-0563
    Keywords: Key words Germ cell tumours • High dose chemotherapy (HDCT) • Risk factors • Stem cell separation • Stem cell reinfusion ; Schlüsselwörter Keimzelltumoren • Hochdosischemotherapie (HDCT) • Risikofaktoren • Stammzellseparation • Stammzellreinfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Hochdosischemotherapie (HDCT) ist für Patienten mit prognostisch ungünstigen Keimzelltumoren eine vielversprechende Behandlungsform. Für den erstbehandelnden Urologen besteht die Schwierigkeit, Patientengruppen zu selektionieren, die für diese Therapie in Betracht kommen und profitieren können. Entsprechend sorgfältig müssen die Indikationen herausgearbeitet werden. Die Ausschlußkriterien beziehen sich vor allem auf beeinträchtigte Organreserven. Vor einer HDCT werden nach vorangegangenen konventionell dosierten Chemotherapiezyklen hämatopoetische Stammzellen mit G- oder GM-CSF-Unterstützung gewonnen. Für die HDCT werden Kombinationen von Carboplatin, Etoposid und Ifosfamid oder Cyclophosphamid eingesetzt. Hämatologische Überwachung und der Einsatz aller erforderlichen supportiven Maßnahmen sind unabdingbare Voraussetzungen, um Patienten nicht zu Schaden kommen zu lassen. Deshalb wird empfohlen, eine HDCT nur an geeigneten Zentren durchzuführen.
    Notes: Summary High-dose chemotherapy (HDCT) is a promising treatment for patients with germ cell tumours and a poor prognosis. The selection of patients who may profit from this intervention is challenging for the urologist, as the indication has to be carefully established. Exclusion criteria primarily concern impaired organ functions. Prior to HDCT haematopoietic stem cells are obtained after the administration of conventional-dose chemotherapy plus G- or GM-CSF stimulation. HDCT consists of a combination of carboplatin, etoposide and ifosfamide or cyclophosphamide. After HDCT, haematologic monitoring and maximal supportive care are essential. It is therefore recommended that HDCT only be administered at specialized centres.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001200050138
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  • 6
    Electronic Resource
    Electronic Resource
    Chemotherapy for bone marrow relapse of childhood acute lymphoblastic leukemia (1989)
    Springer
    Cancer chemotherapy and pharmacology 24 (1989), S. S16 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Results of the BMF study group trials ALL-REZ 83 and 85 for relapsed acute lymphoblastic leukemia (ALL) are presented. For children with late marrow relapse, remission rates of about 90% were seen in both studies. In children treated for early marrow relapse, the remission rate in study ALL-REZ 85 was superior (86% vs 62%). The probability of event-free survival for all patients and for those with early marrow relapse was also statistically significant (P〈0.05). Children with T-cell ALL had an extremely unfavourable prognosis in both studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253232
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  • 7
    Electronic Resource
    Electronic Resource
    Antifolate effect of triamterene on human leucocytes and on a human lymphoma cell line (1981)
    Springer
    European journal of clinical pharmacology 20 (1981), S. 219-224 
    Details
    ISSN: 1432-1041
    Keywords: triamterene ; folate antagonism ; triamterene metabolites ; dihydrofolate reductase ; DNA metabolism ; human leucocytes ; BJAB-B95-8 ; lymphoma cell line
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The inhibitory effect of triamterene and its metabolites on human leucocyte dihydrofolate reductase has been studied. Under test conditions with dihydrofolic acid 0.5×10−5 M, triamterene 7×10−5 M produced total enzyme inhibition, whereas the metabolites hydroxytriamterene and the sulphate ester of hydroxytriamterene were less effective inhibitors; at their maximum attainable concentration of 5×10−5 M, dihydrofolate reductase was inhibited by 80% and 50%, respectively. Cultures of the BJAB-B95-8 human lymphoma cell line were incubated with various concentrations of triamterene. Because of their increased specific activity of dihydrofolate reductase, the cells were able to maintain normal DNA metabolism, as measured by the ratio of the incorporation rates of 3H-deoxyuridine and 3H-thymidine, as well as normal cell growth at 1×10−6 M, and in some cases at 1 × 10−5 M triamterene. At 8×10−5 M triamterene, the strong inhibitory effect caused severe impairment of DNA metabolism and subsequently dissolution of the cell culture. The results are discussed in relation to the possible toxic side effects of long-term triamterene treatment in patients suffering from alcoholic cirrhosis, who may have impaired metabolism of triamterene and a concomitant severe folate deficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544601
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  • 8
    Electronic Resource
    Electronic Resource
    Influence of Nb Content and Processing Conditions on Microstructure and Functional Properties of NiTiNb Shape-Memory Alloys (2002)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 394-395 (May 2002), p. 361-364 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/06/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.394-395.361.pdf
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  • 9
    Electronic Resource
    Electronic Resource
    Ectoenzymes on the surface of cells from human lymphoblastoid lines: 5′-Nucleotidase and phosphatase (1980)
    Springer
    Annals of hematology 41 (1980), S. 411-420 
    Details
    ISSN: 1432-0584
    Keywords: Menschliche Lymphoblastenlinien ; Ekto-5′-Nukleotidase ; Ekto-Phosphatase ; Human lymphoblastoid lines ; Ecto-5′-nucleotidase ; Ecto-phosphatase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Activities of the ecto-enzymes 5′-nucleotidase (5′-N) and phosphatase were determined on the surface of intact cells from 15 different established lines of human B- and T-lymphoblasts. Whereas all the lines express phosphatase, 10 of the lines were negative for 5′-N. 5′-N-negative cell lines are found among B as well as T cells, and they do not carry cryptic enzyme activity. In a 5′-N-positive line activity of this enzyme is correlated with growth showing a peak during the logarithmic phase. On the other hand, inhibition of 5′-N does not change the growth curve of this line. Neuraminidase treatment of the cell surface brings about an increase in phosphatase but not in 5′-N activity. 5′-N of two B-cell lines and of human peripheral blood lymphocytes shows complete crossreactivity with an antiserum obtained against human placental 5′-N. However, the enzyme of one lymphoma line with B-cell properties (EHR-A-Ramos) does not cross-react with this serum. The results are discussed with respect to suitability of these lymphoblast lines as model systems for the study of immunodeficiencies.
    Notes: Zusammenfassung Aktivitäten der Ektoenzyme 5′-Nukleotidase (5′-N) und Phosphatase wurden gemessen an intakten Zellen aus 15 verschiedenen etablierten Linien menschlicher B- und T-Lymphoblasten. Während Phosphatase auf allen Zellinien exprimiert wird, waren 10 der untersuchten Linien negativ für 5′-N. 5′-N-negative Linien finden sich sowohl unter B- als auch T-Zellen; sie tragen auch keine kryptische Enzymaktivität. In einer 5′-N-positiven Linie folgt die Enzymaktivität der Wachstumskurve mit einem Maximum während der logarithmischen Phase. Andererseits ändert Hemmung der 5′-N nichts an der Wachstumscharakteristik dieser Zellinie. Neuraminidasebehandlung der Zelloberfläche bringt eine Steigerung der Phosphatase-, nicht jedoch der 5′-N-Aktivität mit sich. 5′-N auf zwei B-Zellinien und auf menschlichen peripheren Blutlymphozyten zeigt komplette Kreuzreaktivität mit einem Antiserum gegen 5′-N aus menschlicher Plazenta. Dagegen kreuzreagiert 5′-N einer weiteren Lymphomlinie mit B-Zell-Eigenschaften (EHR-A-Ramos) nicht mit diesem Serum. Die Brauchbarkeit dieser Lymphoblastenlinien als Modellsysteme zum Studium von Immundefizienzen wird diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01007765
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  • 10
    Electronic Resource
    Electronic Resource
    Hexose transport in epstein-barr virus (EBV) negative lymphoma lines and their EBV converted, virus genome carrying sublines (1981)
    Springer
    Annals of hematology 43 (1981), S. 297-305 
    Details
    ISSN: 1432-0584
    Keywords: Epstein-Barr Virus ; Lymphoma cell lines ; Viral transformation ; Hexose uptake
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Increased hexose uptake is a marker for viral transformation, as has been shown in non-human fibroblasts transformed by oncogenic viruses. If this phenomenon is a general expression of viral induced transformation it should also apply on different oncogenic virus-cell systems. Recently two human EBV-negative lymphoma lines were converted to a stable EBV-positive state by infection with EBV. According to their biochemical and biological properties they enable us to study events associated with EBV-transformation. We analysed the uptake of (3H) glucosamine and (3H) 2-deoxy-D-glucose into BJAB and Ramos and their EBV-converted sublines and found a clear increase of the rate of uptake of both sugars in the EBV-positive sublines. Control experiments confirmed that the increased uptake was due to alterations on the level of the hexose membrane carriers and not due to increased metabolism. The observation of increased hexose uptake in the only presently available virus transformed human cell system is a strong argument for the general importance of this transformation-associated membrane change.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320953
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