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  • 1
    Electronic Resource
    Electronic Resource
    The effects of an extradural expanding lesion on regional intracranial pressure, blood flow, somatosensory conduction and brain herniation: an experimental study in baboons (1990)
    Springer
    Acta neurochirurgica 104 (1990), S. 30-37 
    Details
    ISSN: 0942-0940
    Keywords: Intracranial pressure ; cerebral blood flow ; somatosensory evoked potentials ; tentorial herniation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intracranial pressure (ICP) differences, change of local blood flow (CBF) using the hydrogen clearance technique, change in the somatosensory evoked potential (SEP) to median nerve stimulation and pupillary size were investigated during progressive elevation of the ICP (using an extradural balloon) in 6 anaesthetized baboons. CBF was measured in the frontal cortex, somatosensory cortex, thalamus (nucleus ventralis posterior lateralis—VPL), medial lemniscus (ML), lateral lemniscus (LL) and caudate nucleus (CN). Conduction along the somatosensory pathway between C 2 at the neck and VPL was compared with conduction between VPL and primary somatosensory cortex. The amplitude of the cortical SEP was also studied. ICP gradients between hemispheres developed as the pressure was increased to in excess of 50 mm Hg. CBF was significantly reduced from control in the cortex and VPL on the side ipsilateral to the balloon at 50 mm Hg ICP. A significant decrease in ML flow occurred bilaterally at 70 mm Hg ICP. Conduction time was increased significantly between the right VPL and cortex at a pressure of 50 mm Hg. The amplitude of the cortical response was significantly reduced at 30 mm Hg on the right side and 50 mm Hg on the left. Aniscoria occurred at 50 mm Hg ICP and the pupils became dilated at 70 mm Hg. The SEP was possibly more sensitive than the pupillary reactions as an indication of tentorial herniation in these experiments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01842890
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of an expanding supratentorial mass on the auditory brain-stem responses in baboons (1986)
    Springer
    Acta neurochirurgica 79 (1986), S. 132-138 
    Details
    ISSN: 0942-0940
    Keywords: Intracranial pressure ; supratentorial mass lesions ; transtentorial herniation ; pupillary change ; auditory brain-stem responses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study was carried out to investigate the effects of an expanding supratentorial mass on auditory brain-stem responses (ABRs). A balloon was inserted into the supratentorial epidural space of seven baboons (in two cases, in the right occipital area; in five cases, in the right temporal area). The balloons were inflated at a rate of 0.2 ml/minute to increase intracranial pressure (ICP). ICP (right frontal epidural pressure) and blood pressure (BP) were continuously recorded. Recordings of ABRs (vertex to mastoid on both sides) were made serially. Pupillary changes were also recorded. At 30mmHg ICP, the amplitude of wave V on the right side was observed to be significantly attenuated (p〈0.02). At 50 mm Hg ICP, the latency of wave V on the right side was significantly prolonged compared with that at 30mmHg ICP (p 〈 0.02). At 70mmHg ICP, significantly decreased amplitude of wave V on the left side was also observed (p〈0.02, from the control), associated with significant increased latency of wave IV on the right side (p〈0.01, from the control; p 〈0.05, from 50 mm Hg ICP). Finally, waves IV and V on both sides substantially disappeared at 100 mm Hg ICP. Anisocoria appeared in four animals at 30–50 mm Hg (mean ±SD; 45±8.7) ICP. The amplitude of wave V was significantly decreased in these circumstances (p〈0.05). Bilaterally fixed pupils occurred in five animals at 70–100 mm Hg (mean±SD; 76 ±12) ICP. wave IV latencies on both sides were significantly prolonged (p〈0.02 right; p〈0.05, left) and disappearance of wave V (four out of five on the right side, three out of five on the left side) was observed in these circumstances. These findings suggest that serial measurement of ABRs can be useful for evaluation of the progress of transtentorial herniation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01407457
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  • 3
    Electronic Resource
    Electronic Resource
    The results of anterior cervical fusion in cervical spondylosis (1983)
    Springer
    Acta neurochirurgica 68 (1983), S. 277-288 
    Details
    ISSN: 0942-0940
    Keywords: Cervical spondylosis ; cervical myelopathy ; anterior cervical fusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A retrospective study of 125 patients with cervical spondylosis with, in the main, myelographic features, and treated by the anterior cervical route (Cloward's operation) is presented. Patients were selected for this type of surgery as opposed to the posterior approach, on clinical and radiological grounds which are described. Results of this treatment have generally been good and this is particularly so in very elderly patients with a single lesion at C 3/4. There is a group of patients in whom the disease process seems to progress despite surgery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01401185
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  • 4
    Electronic Resource
    Electronic Resource
    Colloid cysts of the third ventricle a review of 36 cases (1985)
    Springer
    Acta neurochirurgica 76 (1985), S. 99-104 
    Details
    ISSN: 0942-0940
    Keywords: Colloid cyst ; normal pressure hydrocephalus ; CT scan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thirty-six colloid cysts were treated from 1949 to 1983. There were 26 male and 10 female patients, ranging in age from 12 to 65 years old, 60% between 31 and 40 years. Headache or disturbed mental function was the most frequent complaint, papilloedema the most frequent sign. The patients were classified into 3 groups by symptoms and signs; Group I (17 patients): Headache, papilloedema and no neurological signs. Group II (6 patients): Fluctuating or progressive dementia. Group III: Twelve cases with “classical” features, episodic headache and drop attacks. One patient could not be classified in any of these groups. Seventeen of 36 patients were diagnosed by ventriculography, 19 patients were diagnosed by CT scan. CT scan was the most reliable diagnostic study, but was unavailable in the earlier part of the series. All patients have been operated by transventricular exposure of the right foramen of Munro with incision of the middle frontal gyrus in an antero-posterior linear manner. Twenty-five of 36 patients showed an excellent operative result, and nine had a good result, one of the 9 patients dying of an unrelated intracerebral haemorrhage 4 years after operation. Two patients had a poor result, characterized by memory loss and confusion. One of these died of an unknown cause 5 years after operation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01418468
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  • 5
    Electronic Resource
    Electronic Resource
    Some Difficult Issues in Recent Apparel Manufacturing and a Counter-measure for the Future (1994)
    Bingley : Emerald
    International journal of clothing science & technology 6 (1994), S. 14-16 
    Details
    ISSN: 0955-6222
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Reports on difficult issues regarding recent trends in men's suiting. Lighter weights cause many technical problems in apparel manufacture.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/09556229410063486
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  • 6
    Electronic Resource
    Electronic Resource
    Treatment of malignant brain tumor with slowly releasing anticancer drug-polymer composites
    Amsterdam : Elsevier
    International Journal of Radiation Applications & Instrumentation. Part C, 39 (1992), S. 521-525 
    Details
    ISSN: 1359-0197
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/1359-0197(92)90107-Q
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  • 7
    Electronic Resource
    Electronic Resource
    The detection of H"2 gas by metal phthalocyanine-based gas sensors
    Amsterdam : Elsevier
    Sensors and Actuators B: Chemical 9 (1992), S. 85-90 
    Details
    ISSN: 0925-4005
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0925-4005(92)80200-H
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  • 8
    Electronic Resource
    Electronic Resource
    Expression of the EP4 Prostaglandin E2 Receptor Subtype with Rat Dextran Sodium Sulphate Colitis: Colitis Suppression by a Selective Agonist, ONO-AE1-329 (2002)
    Oxford, UK : Blackwell Science Ltd
    Scandinavian journal of immunology 56 (2002), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Expression of the EP4 receptor, a prostaglandin (PG)E2 receptor subtype, as well as disease suppression by the administration of a selective EP4 agonist (ONO-AE1-329) was investigated in the colorectal mucosa of rats with dextran sodium sulphate (DSS)-induced colitis. Rats were given drinking water containing 3% DSS for 2 weeks. Expression of EP4 receptor mRNA was barely detectable under normal conditions according to reverse transcription-polymerase chain reaction (RT-PCR). By 1 week after the initial administration of DSS, the receptor mRNA was strongly expressed. After ONO-AE1-329 was administered intracolonically to rats with DSS colitis for 7 consecutive days, erosion and ulceration decreased. Peripheral white blood cell (WBC) counts became less elevated. Interleukin (IL)-1β and growth-regulated gene product/cytokine-induced neutrophil chemoattractant (GRO/CINC-1) concentrations in colorectal mucosa were lower than in colitis control group (IL-1β: 12.8 ± 4.6 and 30.8 ± 6.2 µg/mg protein, P 〈 0.05; GRO/CINC-1: 15.5 ± 3.0 and 39.2 ± 5.4 µg/mg protein, P 〈 0.05), and the expression of the corresponding cytokine mRNA was strongly suppressed. IL-10 concentration was higher than in control group (14.5 ± 1.7 and 7.9 ± 1.2 µg/mg, P 〈 0.05), and the mRNA was more strongly expressed. These results suggest that the EP4 receptor is important in colonic inflammation, and that PGE2 suppresses DSS colitis at least partly via the EP4 receptor and the above cytokine changes. Intracolonic administration of selective EP4 agonist might have therapeutic applicability in inflammatory bowel disease such as ulcerative colitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.2002.01096.x
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  • 9
    Electronic Resource
    Electronic Resource
    Enprostil, a Prostaglandin-E2 Analogue, Inhibits Interleukin-8 Production of Human Colonic Epithelial Cell Lines (2000)
    Oxford, UK : Blackwell Science Ltd
    Scandinavian journal of immunology 52 (2000), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We previously reported that intracolonic administration of enprostil, a prostaglandin-E2 (PGE2) analogue, had therapeutic effects on acute colitis induced in rodents by dextran sulfate sodium (DSS). In addition, production of growth-regulated gene product/cytokine-induced neutrophil chemoattractant-1 [GRO/CINC-1; an interleukin(IL)-8 like cytokine] was suppressed in the inflamed tissues. In the present study we used a human colon cancer cell line (HT-29) to investigate enprostil effects on the IL-8 production of intestinal epithelial cells stimulated by various stimulants. In a MTT assay, concentrations of enprostil 〉10−5M had cytotoxitic effects on HT-29 cells. Furthermore, 10−6 M enprostil suppressed IL-8 production in HT-29 cells, SW620 and CaCo2 stimulated with interleukin-1β (IL-1β) or lipopolysaccharide (LPS), but did not suppress this response when cells were stimulated with tumour necrosis factor (TNF)-α. These results suggest that enprostil affects a point in the pathway between the IL-1 receptor or LPS receptor and nuclear factor-κB(NF-κB), without affecting the pathway between the TNF receptor and NF-κB, with the latter factor being required for the IL-8 gene transcription. The therapeutic effect of exogenous enprostil on DSS colitis may involve the inhibition of IL-8 production in colonic epithelial cells stimulated by IL-1β or LPS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.2000.00815.x
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  • 10
    Electronic Resource
    Electronic Resource
    Hysteresis loop observed in temperature dependence of resistivities by SnO"2-based gas sensors
    Amsterdam : Elsevier
    Solid State Electronics 33 (1990), S. 467-469 
    Details
    ISSN: 0038-1101
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0038-1101(90)90052-G
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