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  • 1
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0738
    Keywords: Key words O6-methylguanine DNA methyltransferase (MGMT) ; Formaldehyde ; Mononuclear blood cells ; DNA repair
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A recent study reported that exposure of student embalmers in Cincinnati to high concentrations of formaldehyde (2 mg/m3) reduced the activity of the DNA repair protein O6-methylguanine DNA methyltransferase (MGMT). Reduction in a DNA repair enzyme may strongly increase the cancer risk not only with respect to the repair-enzyme causing agent but with respect to all carcinogens causing lesions subject to repair by the enzyme in question. Thus, we examined whether formaldehyde exposure of 57 medical students during their anatomy course at two different Universities in Germany influenced MGMT activity in mononuclear blood cells. Mean formaldehyde exposure of 41 students was 0.2 ± 0.05 mg/m3 for 6 h per week. MGMT activity was 133.2 ± 14.9 fmol MGMT/106 cells before the beginning of the formaldehyde exposure, 131.1 ± 15.8 fmol MGMT/106 cells after 50 days (P = 0.56) and 128.2 ± 19.0 fmol MGMT/106 cells after 111 days of exposure (P=0.92). Similarly, no significant influence of formaldehyde exposure was observed, when smoking habits, alcohol consumption, allergic disease and sex of students were considered. In addition no significant difference was obtained in MGMT activity between 16 students with mean formaldehyde exposure of 0.8 ± 0.6 mg/m3 and students without formaldehyde exposure (n=51; P=0.37). In conclusion, exposure of the medical students in western Europe to formaldehyde did not decrease MGMT activity in mononuclear blood cells.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 89 (1988), S. 5950-5955 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Infrared and Raman spectra of the discotic liquid crystal molecules benzene–hexa-hexanoate (BH6), benzene–hexa-heptanoate (BH7), benzene–hexa-octanoate (BH8), and benzene–hexa-nananoate (BH9), and of mixtures of BH7 with BH8, are reported as a function of temperature. The 1615 cm−1 infrared band is strong in the Raman spectrum of BH7 and is taken as a characteristic of and diagnostic for central core disorder in all these molecules and mixtures. The aliphatic side chains are shown to disorder at much lower temperatures than the central core, and order in the central core is shown to remain throughout the liquid crystalline region.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Clinica Chimica Acta 224 (1994), S. 21-32 
    ISSN: 0009-8981
    Keywords: Centrifugal field ; HDL ; LDL ; Lipoproteins ; Tabletop ultracentrifuge ; VLDL
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Der Internist 40 (1999), S. 922-929 
    ISSN: 1432-1289
    Keywords: Schlüsselwörter Rheumatoide Arthritis ; Rheumatoide Vaskulitis ; Riesenzellarteriitis ; Polymyalgia rheumatica
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zum Thema Das klinische Syndrom der rheumatoiden Vaskulitis (RV) hat sich in den letzten 40 Jahren als Begriff in der Rheumatologie etabliert, ohne daß es bisher eine feststehende Begriffsdefiniton gibt. Bei der rheumatoiden Arthritis (RA), einer chronisch entzündlichen Erkrankung des Bindegewebes mit bevorzugtem Befall der Gelenkinnenhaut und daraus resultierender Knorpel- und Knochendestruktion werden häufig extraartikuläre Erscheinungen beobachtet, deren bekannteste das Auftreten von Rheumaknoten darstellt (Rheumatismus nodosus). Auch bei der Riesenzellarteriitis (RZA) ergeben die Laborbefunde oft ausgeprägte Entzündungskonstellationen, obwohl das morphologische Substrat dieser Entzündung noch nicht restlos geklärt zu sein scheint. Das klinische Syndrom der Polymyalgia rheumatica (PMR) ist mit der RZA sehr häufig assoziiert, aber auch die RA im höheren Lebensalter bereitet differentialdiagnostisch wegen ihrer zu Beginn häufig polymyalgiformen Symptomatik große Probleme, zumal auch flüchtige Synovitiden vor allem an Knie- und Handgelenken bei der PMR beobachtet werden. Aus der Entzündung und Schädigung von Blutgefäßen resultieren Lumeneinengung und damit Ischämie im vom betroffenen Gefäß versorgten Gewebe, die bei der Arteriitis cranialis zur Erblindung führen kann. Aus Permeabilitätsstörungen der Endstrecken im Gefäßbett entstehen Schädigungen der molekularen Austauschflächen in Organen wie Niere oder Lunge bis hin zum Organversagen.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 69 (1957), S. 515-515 
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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