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  • 1
    Electronic Resource
    Electronic Resource
    Secretory characteristics of pancreatic γ-glutamyl transpeptidase (1973)
    Springer
    Pflügers Archiv 345 (1973), S. 271-279 
    Details
    ISSN: 1432-2013
    Keywords: Pancreatic Secretion ; γ-Glutamyl Transpeptidase ; Amylase ; Protein ; Leucine Aminopeptidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In an attempt to identify the secretory mechanism of pancreatic γ-glutamyl transpeptidase (γ-GTP), constant intravenous infusions of secretin alone and in combination with caerulein were performed in anesthetized dogs prepared with a pancreatic fistula. Caerulein produced a marked increase in amylase concentration and only a slight increase in γ-GTP. γ-GTP concentration of the pancreatic juice varied from 12 to 490 mU per ml which ranged up to 188-fold higher than that of the serum. The enzyme concentration depended largely on the flow rate, revealing 3 characteristic curvlinear relationship, regardless of whether caerulein was added to the secretin infusion. No significant relation was demonstrated between amylase concentration and flow rate, amylase and γ-GTP concentrations, and γ-GTP and protein concentration. An inverse linear correlation between γ-GTP and chloride concentrations was obtained when flow rate was below 2.5 ml per 15 min. A significant linear relationship was demonstrated between γ-GTP and leucine aminopeptidase concentrations, and amylase and protein concentrations. The results presented clearly demonstrate that the mechanism of pancreatic secretion of γ-GTP is quite distinct from that of amylase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00585846
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Chronic pancreatitis at early age of onset presenting interesting findings through endoscopic retrograde pancreatography and chemical analysis of nonopaque pancreatic concretion (1987)
    Springer
    Digestive diseases and sciences 32 (1987), S. 433-440 
    Details
    ISSN: 1573-2568
    Keywords: chronic pancreatitis ; x-ray translucent (nonopaque) concretions ; endoscopic retrograde cholangiopancreatography ; elemental analysis ; intrared absorption spectrum ; amino acid analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This case concerns a 20-year-old male patient with an approximate 10-year history of recurrent and severe abdominal pain radiating to the back. Endoscopic retrograde cholangiopancreatography revealed a short obstructing stenosis of the main pancreatic duct in the head of the pancreas, marked and tortuous dilatation of the prestenotic portion of the main pancreatic duct and its side branches, and a filling defect in the side branch in the body of the gland. Pancreaticojejunostomy was performed to induce decompression of the pancreatic duct. Histology of the pancreas showed advanced chronic pancreatitis. Three nonopaque concretions were obtained at operation. The largest one, which was milky white in appearance and elastic and soft in consistency, proved to be made up of protein. The concretion was rich in acidic amino acids, but poor in basic or aromatic residues. The molar composition of amino acids in the concretion was, in decreasing order, aspartic acid, serine, valine, glycine, and glutamic acid. Powder x-ray diffractometry revealed no crystalline structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01296299
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Clinical evaluation of pancreatic excretion test with dimethadione and oral BT-PABA test in chronic pancreatitis (1983)
    Springer
    Digestive diseases and sciences 28 (1983), S. 230-235 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Further evaluation of the pancreatic excretion test with 5,5-dimethyl-2,4-oxazolidinedione (dimethadione, DMO) was made in comparison with the pancreozymin-secretin (PS) test on 100 normal subjects, 79 patients with chronic pancreatitis, and 83 patients with nonpancreatic disease. The diagnostic sensitivity of the oralN-benzoyl-l-tyrosyl-PABA (BT-PABA) test was estimated in 42 patients with chronic pancreatitis, on whom both PS and DMO excretion tests were performed as test of reference for exocrine pancreatic function. Pancreatic DMO excretion after secretin injection was significantly diminished in chronic pancreatitis. The DMO excretion test was more sensitive than the PS test to detect chronic pancreatitis and to distinguish between mild to moderate and advanced noncalcific chronic pancreatitis. The specificity of the DMO excretion test was more than adequate to find out pancreatic disease. The 6-hr urinary PABA excretion was significantly reduced in chronic pancreatitis. The BT-PABA test, however, showed the low sensitivity in mild to moderate chronic pancreatitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01295118
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The excretion of 5,5-dimethyl-2,4-oxazolidinedione from the canine pancreas and liver (1973)
    Springer
    Digestive diseases and sciences 18 (1973), S. 498-505 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract With administrations of maximal and supramaximal doses of secretin, the excretion of 5,5-dimethyl-2,4-oxazolidinedione (DMO) into pancreatic juice and bile was studied in the dog. When flow rate and bicarbonate concentration in both of the digestive juices were kept relatively constant by continuous intravenous infusion of secretin (2 units/kg/hr), DMO appeared promptly in them after the intravenous administration; the concentration decreased exponentially, as it did in arterial plasma during a 30-minute period. Equilibrium was achieved within 1 hour in both plasma and pancreatic juice, and nearly attained in 1 hour in both plasma and bile. With single rapid intravenous injections of secretin (2 units/kg and 4 units/kg), pancreatic DMO excretion depended directly on flow rate, bicarbonate concentration, and even on plasma level of the compound, while biliary DMO excretion was dependent at least on flow rate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01076601
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  • 5
    Electronic Resource
    Electronic Resource
    Pancreatic excretion of 5,5-dimethyl-2,4-oxazolidinedione in narmal subjects (1975)
    Springer
    Digestive diseases and sciences 20 (1975), S. 1011-1018 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pancreatic excretion of 5,5-dimethyl-2,4-oxazolidinedione (DMO) was studied in 25 normal subjects using the technique of the traditional pancreatic secretory test. The pancreozymin-secretin test was performed 4 days after the oral administration of trimethadione (3,5,5-trimethyl-2,4-oxazolidinedione, the precursor of DMO) for 3 consecutive days. When a dose of 1 unit/kg of pancreozymin was administered intravenously, both DMO concentration and output of a 10-min fractional specimen were rapidly increased and then decreased gradually. When a dose of 1 unit/kg of secretin was injected 30 min after pancreozymin, DMO concentration in duodenal aspirate showed no significant alteration, while DMO output of the aspirate was remarkably increased and then diminished in parallel to flow rate. DMO concentration in plasma varied widely from subject to subject, but was fairly constant during the course of the test in the same subject. Total DMO output in the postpancreozymin 30-min and postsecretin 60-min periods was linearly related to plasma DMO concentration. The output of DMO, when expressed as the output at a level of 10 mg/100 ml of plasma DMO, was linearly related to secretory volume and bicarbonate and amylase outputs in the postsecretin period. These results led to the conclusion that the human pancreas was capable of excreting a weak organic acid of DMO with a molecular weight of 129.1 and that the excretion of DMO in normal subjects was a function of two factors: plasma DMO concentration and pancreatic secretory volume.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01071188
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  • 6
    Electronic Resource
    Electronic Resource
    Pancreatic excretion of 5,5-dimethyl-2,4-oxazolidinedione in patients with chronic pancreatitis (1975)
    Springer
    Digestive diseases and sciences 20 (1975), S. 1019-1026 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Abnormal pancreatic excretion of 5,5-dimethyl-2,4-oxazolidinedione (DMO) was demonstrated in 44 patients with chronic pancreatitis (14 with calcification and 30 without calcification). Pancreatic excretion of DMO in patients with chronic pancreatitis, as well as in normal subjects, depended on plasma DMO concentration and secretory volume. In the postsecretin 60-min period, almost all patients showed a decrease in total DMO output of duodenal aspirate over the observed range of plasma DMO concentration. More than half the patients without calcification gave a discordant pattern between the DMO output and volume, ie, decreased DMO output with normal volume secretion, while most of patients with calcification had low DMO output with decreased volume flow. The data of the pancreozymin-secretin test suggested that chronic pancreatic inflammation was moderate or minimal in patients without calcification and far advanced in those with calcification. From these results the hypothesis was advanced that DMO diffusion into the pancreatic ducts might be primarily impaired in the relatively early stage of chronic pancretitis, and as the inflammation progressed to the final stage, DMO outflow from the ducts to the duodenum would be disturbed with evolving diffusion impairment of the compound. Total DMO output, when expressed as the output at a level of 10 mg/100 ml of plasma DMO (standard DMO output), was significantly reduced in chronic pancreatitis during a 60-min period after secretin stimulation. DMO in duodenal content, when expressed in terms of maximal concentration ratio of duodenal juice/plasma for the compound (maximalJ/P ratio), was significantly low in chronic pancreatitis during the last 40-min period after secretin stimulation. These two parameters can therefore be used as indices of pancreatic excretion of DMO. The present technique may well become an effective diagnostic tool for early detection of chronic pancreatitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01071189
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    Paper (German National Licenses)
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