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  • 1
    Electronic Resource
    Electronic Resource
    B-Cell Epitopes in the Immunodominant p34 Antigen of Mycobacterium avium ssp. paratuberculosis Recognized by Antibodies from Infected Cattle (2003)
    Oxford, UK : Blackwell Science Ltd
    Scandinavian journal of immunology 58 (2003), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Mycobacterium avium ssp. paratuberculosis (M. paratuberculosis) causes Johne's disease, a chronic and fatal enteritis in ruminants. In the last stage of the disease, antibody titres rise and levels of interferon-γ decrease, suggesting that the host–immune response is switching from a T helper 1 (Th1) to a Th2 profile. In infected cattle, the membrane protein p34 elicits the predominant humoral response against M. paratuberculosis. To map the B-cell epitopes of this antigen, affinity-purified bovine antibodies against the carboxy-terminal region of p34 were used to screen a 12-mer phage display library. Several phage clones carrying peptides resembling fragments of p34 were affinity selected. Based on the predicted amino acid sequence, peptides were chemically synthesized, which demonstrated reactivity with serum from naturally infected and p34-vaccinated cattle. Immunization of mice with these peptides elicited an anti-p34 antibody response. Two B-cell epitopes were identified and characterized. Based on the reactivity and the type of immune response elicited, epitope A was determined to be conformational, whereas epitope B was demonstrated to be sequential. Both epitopes were shown to be present in p34 proteins from M. avium ssp. avium or M. paratuberculosis but absent from M. intracellulare, the other member of the M. avium complex. Furthermore, both epitopes were mapped to regions of p34 that display high variability when compared to homologous proteins from other mycobacterial species of public and animal health importance. We hypothesize that these variable regions of p34 may play a role in the immunobiology of M. paratuberculosis infections.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.2003.01334.x
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  • 2
    Electronic Resource
    Electronic Resource
    Retention indices of dimethylbenzamidines and benzylideneamines on a non-polar column
    Amsterdam : Elsevier
    Journal of Chromatography A 330 (1985), S. 79-85 
    Details
    ISSN: 0021-9673
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0021-9673(01)81964-6
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  • 3
    Electronic Resource
    Electronic Resource
    Impulsantworten des Nervus opticus auf Reizung der Netzhaut mit Acetylcholin (1969)
    Springer
    Cellular and molecular life sciences 25 (1969), S. 370-371 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Application of ACh on the isolated perfused retina of the frog elicited spikes of the optic nerve. The extent of this spike activity depended on the amount of ACh applied. The retinal response to ACh was varied by prostigmine and atropine as expected by their pharmacological properties. From these experiments it cannot be concluded that ACh is acting on the synapses of the firing ganglion cells directly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01899924
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  • 4
    Electronic Resource
    Electronic Resource
    On detection of high-energy neutrinos from sources of gamma-ray bursts (1995)
    Springer
    Astrophysics and space science 231 (1995), S. 339-341 
    Details
    ISSN: 1572-946X
    Keywords: Gamma-ray bursts ; High-energy neutrinos
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We show that, contrary to a recent suggestion, fluxes of ∼ 30 GeV-1 TeV neutrinos that may accompanyγ-ray bursts are at least a few orders of magnitude too weak to be detected by the current or planned neutrino detectors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00658646
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  • 5
    Electronic Resource
    Electronic Resource
    Steady-state versus viscous cosmology (1982)
    Springer
    Astrophysics and space science 87 (1982), S. 425-433 
    Details
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Hoyle's steady-state cosmology and relativistic Robertson-Walker world models with a constant bulk viscosity are briefly reviewed and compared. It is shown that, although they are identifical from a purely formal point of view, the interpretation of Hoyle's model in terms of viscous dissipation would be physically unrealistic.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00648934
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  • 6
    Electronic Resource
    Electronic Resource
    Sphingomonads from marine environments (1999)
    Springer
    Journal of industrial microbiology and biotechnology 23 (1999), S. 268-272 
    Details
    ISSN: 1476-5535
    Keywords: Keywords: marine; Sphingomonas; phylogeny; oligotroph
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Sphingomonas species play an important role in the ecology of a range of marine habitats. Isolates and 16S-rRNA clones have been obtained from corals, natural and artificial sources of marine hydrocarbons and eutrophic and oligotrophic waters, and have been isolated as hosts for marine phages. In addition they are found in oceans spanning temperature ranges from polar to temperate waters. While less is known about marine sphingomonads in comparison to their terrestrial counterparts, their importance in microbial ecology is evident. This is illustrated by, for example, the numerical dominance of strain RB2256 in oligotrophic waters. Furthermore, the known marine sphingomonads represent a phylogenetic cross-section of the Sphingomonas genus. This review focuses on our present knowledge of cultured isolates and 16S-rDNA clones from marine environments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/sj.jim.2900732
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  • 7
    Electronic Resource
    Electronic Resource
    Sixty percent salvage rate for germ-cell tumours using sequential m-BOP, surgery and ifosfamide-based chemotherapy (1999)
    Springer
    Annals of oncology 10 (1999), S. 685-692 
    Details
    ISSN: 1569-8041
    Keywords: cisplatin ; dose dense ; germ-cell tumour ; salvage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: In germ-cell tumours (GCT), there is continuing controversy over the relative merits of dose dense therapy (increased frequency over a given time) versus vertical intensification (increased dose per fraction). The value of using a cisplatin-based dose dense approach in the salvage setting has not been documented and in addition the role of methotrexate remains uncertain. This paper reviews results from our investigations of these issues. Patients and methods: Between 1987 and 1996, 65 patients with relapsing or refractory germ-cell tumour received weekly m-BOP (methotrexate, bleomycin, vincristine and cisplatin) as salvage therapy. Residual masses were excised if possible and patients progressing after this received cisplatin and ifosfamide based chemotherapy with or without high dose chemotherapy (HDCT) consolidation. Results: With a median follow-up of 33 months, 34% are progression free following m-BOP, 11% who had surgery for residual masses which showed viable cancers are progression free. A further 15% who progressed following m-BOP with or without surgery were rendered progression free by third-line therapy. Conclusions: The use of m-BOP as second line therapy with deferment of cisplatin and ifosfamide based treatment to third line therapy with consolidation of third line responses with HDCT, leads to an overall progression-free survival of 60%. It does not appear that M-BOP prejudiced the response to third line therapy suggesting a lack of cross resistance. The potentially lower risk of leukaemia and infertility from m-BOP requires further evaluation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008318612005
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  • 8
    Electronic Resource
    Electronic Resource
    Performance of Connectionless Data Service in High Density Microcell (1997)
    Springer
    Wireless personal communications 4 (1997), S. 207-216 
    Details
    ISSN: 1572-834X
    Keywords: wireless ; microcell ; packed ; data ; CDPD
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Abstract Two categories of commercial wireless packet services exist today – a standalone system where the entire bandwidth is dedicated to the transmission of data packets (e.g. ARDIS, Mobitex), and an overlay system, where the unused channels of an existing cellular phone system are used (e.g. CDPD, GPRS). This paper examines the performance of the overlay service in a high density Manhattan street grid microcell. This type of cell is common in central urban areas. A simple analytical model is derived to describe the channel occupancy distribution in the microcell. The model is used to examine the performance of CDPD, a connectionless data service operating over a cellular system. Throughput and latency are evaluated under the two existing channel assignment schemes currently in use. A new assignment scheme is proposed, and is found to give better performance with minimal changes to the CDPD specification.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008869013540
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  • 9
    Electronic Resource
    Electronic Resource
    Bacterial and chemical leaching pattern on copper ores of sandstone and limestone type (1993)
    Springer
    World journal of microbiology and biotechnology 9 (1993), S. 328-331 
    Details
    ISSN: 1573-0972
    Keywords: Biological film ; leaching pattern ; Thiobacillus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Thin polished sections of copper sulphide ore were placed as an energy source in stationary cultures of wild strains and Thiobacillus neapolitanus at pH 7.5. Scanning electron microscopy revealed characteristic leaching patterns that depended on the type of leaching process and time of bioleaching. In some cases, a biological film on the ore surface was observed. Close contact between bacterial cells and ore seems necessary for leaching in some cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00383073
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  • 10
    Electronic Resource
    Electronic Resource
    Cosmic-ray diffusive acceleration at shock waves with finite upstream and downstream escape boundaries (1996)
    Springer
    Solar physics 167 (1996), S. 381-394 
    Details
    ISSN: 1573-093X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract In the present paper we discuss the modifications introduced into the first-order Fermi shock acceleration process due to a finite extent of diffusive regions near the shock or due to boundary conditions leading to an increased particle escape upstream and/or downstream of the shock. In the simple example of the planar shock wave considered we idealize the escape phenomenon by imposing a particle escape boundary at some distance from the shock. The presence of such a boundary (or boundaries) leads to coupled steepening of the accelerated particle spectrum and decreasing of the acceleration time scale. It allows for a semi-quantitative evaluation and, in some specific cases, also for modelling of the observed steep particle spectra as a result of the first-order Fermi shock acceleration. We also note that the particles close to the upper energy cut-off are younger than the estimate based on the respective acceleration time scale. In Appendix A we present a new time-dependent solution for infinite diffusive regions near the shock allowing for different constant diffusion coefficients upstream and downstream of the shock.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00146347
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