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  • 1
    Electronic Resource
    Electronic Resource
    The solubility properties of granulopoiesis inhibiting factor (1975)
    Springer
    Cellular and molecular life sciences 31 (1975), S. 1357-1359 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The solubility of granulopoiesis inhibiting factor (GIF) in various aqueous and organic solvents was investigated. GIF is soluble in water, 10% acetic acid, and 10% pyridine. It is not extractable by 1-butanol at low and high pH. A high solubility was found in polar organic solvents (ethanol-acetone 9∶1, and chloroformmethanol 1∶1), whereas GIF seems to be insoluble in pure chloroform.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01945825
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  • 2
    Electronic Resource
    Electronic Resource
    Colony stimulating activity in acute and chronic endotoxinemia in man (1979)
    Springer
    Cellular and molecular life sciences 35 (1979), S. 1398-1400 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Blood granulocyte-macrophage colony stimulating activity (GM CSF) was measured in 6 normal individuals challenged with low-dose endotoxin and in 63 unselected patients with nonhaematological disorders. 5/63 patients were febrile and 5 other patients showed detectable endotoxin levels, as measured by the Limulus assay. CSA levels showed a rapid increase in normal individuals following endotoxin administration, but were in the normal range in patients with chronic endotoxinemia or in those with febrile disorders. Thus, unlike acute endotoxinemia, chronic endotoxinemia is not associated with elevated activity that promotes growth of myeloid commited stem cells. In addition, fever per se did not coincide with elevated blood CSA levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01964032
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  • 3
    Electronic Resource
    Electronic Resource
    Molecular weight and some chemical properties of the Granulocytic Chalone (1978)
    Springer
    Annals of hematology 37 (1978), S. 7-18 
    Details
    ISSN: 1432-0584
    Keywords: Granulopoese ; Chalon ; Koloniebildung ; Granulopoiesis ; Chalone ; Colony formation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Granulocytic Chalone (GCh) has been highly purified from culture medium conditioned by human peripheral leukocytes. Purification was performed by column chromatography on Sephadex G-25 and G-10, rechromatography on G-10, preparative paper chromatography and thin-layer-chromatography. The inhibitory activity and specificity of GCh was monitored by agar colony formation and3H-thymidine incorporation into bone marrow and thymic cells. The gelchromatographic behavior of GCh is discussed in detail with regard to its molecular weight. The results obtained indicate that GCh may be a small (MW 500–600), acidic and highly polar peptide containing aspartic and glutamic acid among others. The N-terminal aminogroup seems to be blocked.
    Notes: Zusammenfassung Ein Peptid, welches sich wie ein Granulozytenchalon verhält, wurde aus durch normale menschliche Leukozyten konditioniertem Medium gewonnen. Die Reinigung erfolgte durch Säulenchromatographie an Sephadex G-25, G-10, Rechromatographie an G-10, Ionenaustauschchromatographie an Dowex 50, sowie durch präparative Papier- und Dünnschichtchromatographie. Die Hemmwirkung und Spezifität wurden mittels der Koloniebildung in Agar sowie durch3H-Thymidineinbau in Knochenmarks- und Thymuszellen nachgewiesen. Das gelchromatographische Verhalten von GCH wird im Hinblick auf das Molgewicht diskutiert. Demnach scheint es sich um ein saures Peptid vom Molgewicht 500–600 zu handeln, welches neben anderen Aminosäuren Asparaginsäure und Glutaminsäure enthält. Die N-terminale Aminogruppe scheint blockiert zu sein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01006548
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  • 4
    Electronic Resource
    Electronic Resource
    Human lung tissue as a source of colony stimulating activity (1978)
    Springer
    Annals of hematology 37 (1978), S. 69-74 
    Details
    ISSN: 1432-0584
    Keywords: Koloniestimulierende Aktivität ; Menschliches Lungen-gewebe ; Alveolar Makrophages ; Colony stimulating activity ; Human lung tissue ; Alveolar macrophages
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Medium conditioned by human lung tissue was found to contain colony stimulating activity (CSA). This material was tested against mouse and human bone marrow as target system. Colony forming units (CFUc)from both species responded and gave rise to clonal growth in agar cultures. This colony formation was dose dependent and the relationship was a sigmoid one. Experiments to determine the molecular weight of human lung derived colony stimulating Factors brought evidence for four active molecular weight fractions with approximately 79000, 40000, 23000 and 2000 daltons. The 23000 dalton fraction activated human cells only, whereas the other fractions were active on both human and mouse bone marrow cells.
    Notes: Zusammenfassung Medium, welches durch menschliches Lungengewebe konditioniert wird, enthält kolonienstimulierende Aktivität (= Colony Stimulating Activity, CSA). Diese Präparation wurde an Menschen- und Mäuseknochenmark getestet. Kolonienbildende Einheiten von beiden Species wurden in Agarkulturen zu klonalem Wachstum aktiviert. Es zeigte sich eine sigmoide Dosisabhängigkeit des Wachtums der CFUc von der Konzentration an lungenkonditioniertem Medium. Die Molekulargewichtsbestimmung der kolonienstimulierenden Faktoren in Lungenmedium ergab vier Molekulargewichtsfraktionen, nämlich mit annähernd 79000,40000,23000und 2000 Daltons. Die 23 000 Dalton-Fraktion aktivierte ausschließlich menschliche Zellen, die übrigen Fraktionen aktivierten Menschen- und Mäuseknochenmarkzellen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01002104
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  • 5
    Electronic Resource
    Electronic Resource
    Cultures of haemopoietic cells: principles and applications (1989)
    Springer
    Cytotechnology 2 (1989), S. 31-33 
    Details
    ISSN: 1573-0778
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02279721
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    Paper (German National Licenses)
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